SEARCH · PubMed Health

Results for “PASTEURELLA PESTIS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 397 records · Page 22Linked to original sources

PubMed1982

[Monthly dynamics of the antitoxic immunity against diphtheria and tetanus and of normal antibodies to fraction I of the plague microbe in adults].

Monthly characteristics of antitoxic immunity to diphtheria and tetanus toxoids in 3,334 adults in Ryazan were determined. As a result, the following differences were established: the characteristics of antidiphtheria immunity were somewhat higher in the autumn-winter period and dropped to the minimal level in the winter-spring period; the maximal characteristics of antitetanus immunity clearly coincided with the hot season, its minimal characteristics with the cold season. For the first time the frequency and titers of normal antibodies to fraction I of Pasteurella pestis in humans were determined. Their monthly dynamics proved to be parallel to the curve indicating the characteristics of antitetanus immunity, but on a lower level: 1-10%. The presence of normal antibodies was accompanied by higher titers to tetanus toxoid, but not to diphtheria toxoid. According to the results of earlier studies, normal antibodies were shown to be the sign of homologous reactivity in inbred animals. Our data indicate that these antibodies can serve as the indirect sign of heterologous reactivity in humans.

Adolescent↗

PubMed1982

[Experience in the comparative evaluation of the population sensitivity of mammals to the plague microbe based on the results of an epizootiological survey].

An essentially new method for the evaluation of the population susceptibility of mammals to Pasteurella pestis without the experimental infection of the animals is proposed. This method consists in using the conjugate result of the mass bacteriological and serological survey of plague carriers (the ratio of the number of infected animals to that of the animals having had the disease). The susceptibility of 12 rodent and Martes species has been studied with the use of this criterion on the basis of the data obtained in the epizootological survey of the plague foci in the vicinity of the Aral Sea in 1950-1979. Among all studied animals, even those belonging to the species universally known as highly susceptible, a considerable prevalence of the animals having had the disease over the infected animals has been established.

Animals↗

PubMed1983

[Quantitative characteristics of the survival phenomenon in experimental plague].

The method for the quantitative evaluation of the effect of the survival phenomenon is proposed, which makes it possible to carry out the rapid single-stage determination of the immunogenicity of Pasteurella pestis avirulent strains. The low specificity of the survival phenomenon in plague has been shown. The accumulation of immunogenic avirulent cells in the population of virulent P. pestis has been found to decrease their pathogenic action to a greater extent than the accumulation of nonimmunogenic avirulent cells.

Animals↗

PubMed1983

[Discrete nature of the antibody affinity of immune sera and the importance of this factor for antigen binding].

After mixing an antibody immunosorbent with Pasteurella pestis monovalent capsular antigen the concentration of the antigen in the free and bound states was evaluated. In this study the test points on the graph were found to be located on the lines characterizing different groups of antibodies differing in their affinity. The verification of the discrete structure of antibody affinity in 10 lots of hyperimmune horse serum showed the truth of this suggestion. The analysis of the role played by different groups of antibodies in binding the antigen indicated the prevailing role of a high-affinity group, especially in the zone with the excess of antibodies.

Animals↗

PubMed1981

[Serum antibody and splenocyte immunoglobulin receptor affinity in multiply immunized mice].

In the process of repeated immunization of CBA mice with soluble Pasteurella pestis capsular antigen the concentration of antibodies in the blood increased, but the dynamics of antibody affinity in the serum did not correlate with this process. For the first time the average splenocyte receptor affinity was measured, and this characteristics was found to exceed that of the corresponding serum antibodies. To explain the heterogeneity of antibodies, two hypotheses have been proposed. One hypothesis states that the heterogeneity of antibodies is determined by the cyclic character of antigen concentration at the site of injection, while according to the other hypothesis, it is determined by the interaction of immunoglobulins of different idiotypes with idiotypic antibodies.

Animals↗

PubMed1982

[Experience using fraction I of the plague microbe for revaccinating experimental animals].

Experiments on guinea pigs have shown that a pronounced revaccination effect develops in the animals receiving the booster injection of fraction I of Pasteurella pestis 1.5--4 months after the primary immunization with live plague vaccine, while the booster injection of live plague vaccine produces a low revaccination effect due to the fact that this vaccine is badly adapted in the body after the primary immunization.

Animals↗

PubMed1981

[Characteristics of Fc IgG receptors on the surface of formalinized sheep erythrocytes].

The binding of IgG molecules with sheep red blood cells (SRBC) was evaluated by a decrease in the serological activity of hyperimmune horse serum towards Pasteurella pestis capsular antigen. As in serological tests based on passive hemagglutination, low concentrations of red blood cells are commonly used, there was no danger of obtaining distorted results due to the nonspecific adsorption of IgG on the surface of SRBC. But for the objective evaluation of the results obtained in the determination of antibody affinity by the suspension method the use of an adequate control was necessary. Fab-fragments, in contrast to IgG, could not be extracted by red blood cells from the solution. The average number of Fc IgG receptors on the surface of one formalinized SRBC was about 60,000, and the affinity of these receptors somewhat varied, the average association constant being KO=10(6), (03) L/M.

Animals↗

PubMed1978

[Production of L forms of the plague microbe].

Experiments were conducted in vitro. The process of formation of unstable L-form cultures of Pasteurella pestis under the effect of penicillin was studied. A comparatively high frequency of this phenomenon in various strains was demonstrated. A possible role of the L-transformation process in the persistence of the causative agent in the organism of wild animals in endemic foci of infection is put forward.

Culture Media↗

PubMed1962