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PubMed1996

[Synthesis of polyfunctional bridging agent-tetrakis (omega-hydroxyproxymethyl) methane and tri (hydroxyproxymethyl) amino methane].

In order to look for the polyfunctional bridging agent. Tetrakis (omega-hydroxyproxymethyl) methane (3) and Tri (omega-hydroxyproxymethyl) aminomethane (4) were prepared from pentaerythritol and trihydroxymethylamino methane respectly. Nine derivatives (5-13) of compounds (3) and (4) were synthesized. The structures of all new compounds (5-13, 15) were confirmed by IR, 1H-NMR and elemental analysis.

Bridged-Ring Compounds↗
PubMed1976

[Angina pectoris. Results of investigations to date (author's transl)].

Among the most important coronary risk factors are a diet rich in saturated fatty acids, cholesterol and calories, hypercholesterolemia, high blood pressure and excessive smoking. The typical pain can be elicited by putting a strain on the patient, e.g. climbing stairs. The disappearance of the pain after treatment with nitroglycerine is one of the most important pointers. Treatment is with nitroglycerine which, moreover, remains the drug of choice, also with nitrates such as pentaerythritol tetranitrate and with betablockers like propranolol. Favorable results have also been reported with a combination of isosorbide dinitrate and propranolol.

Adrenergic beta-Antagonists↗