[New treatment possibilities in obstructive respiratory tract diseases].
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Update statistics of job-related diseases show there is still a high level in reported and also in recognised and financially compensated airway diseases caused by the action of chemically irritating or toxic substances during work. Most reported cases occur in the chemical and metal processing industries. Main triggering substances are said to be isocyanates, aerosols of pollutants produced during welding, cutting, casting or moulding (smoke), by solvents and hair dyes. Experiments prove that a variety of these noxious substances produce dose-dependent hypersensitivity of the bronchial system. Long-term monitoring of granary workers clearly points to both the possibility of and the need for early diagnosis followed by mandatory and immediate abstention from further exposure to avoid occurrence of irreversible disease patterns. Work-related health risks over and above job-conditioned diseases must be generally included in the protective measures in accordance with the new EC guidelines.
Acute respiratory diseases (ARD) due to parvovirus B 19 infection can be observed relative frequently in children. In 21 children (infants, toddlers and school children) we have seen acute or prolonged obstructive bronchitis/bronchiolitis (15 infants), acute subglottic laryngitis (3 toddlers) and acute asthmatic attacks (3 children of school age) in connection with parvovirus B 19 infection. Other respiratory viruses (adeno-, influenza, parainfluenza and RS-virus) could be excluded as agents causing the ARD. We suggest that parvovirus B 19 can provoke ARD with obstructive ventilatory disturbances of the upper or lower airways in children with a specific endogenous predisposition (small or unstable bronchial walls, or bronchial or tracheal mucosal hyperreactivity).
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