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At least 397 records · Page 22Linked to original sources
PubMed2003

Primary jejuno-ileal neoplasms in eastern Nigeria.

Small intestinal neoplasms are uncommon with reported incidences of less than 1% of GI neoplasms. A retrospective review of cases of small intestinal neoplasms seen by the authors in a ten-year period is presented. Ten cases were seen during the period (8 females and 2 males). Seven patients were aged less than 20 years while the rest were aged above 2 years. Six patients presented with intestinal obstruction, 3 with features of chronic ill-health while 1 was an incidental finding. The ileum was involved in 5 patients, the jejunum in 4 while 1 showed multiple gut involvement. One patient had a benign lesion (Peutz-Jeghers Syndrome). The rest consisted of lymphosarcoma [5],adenocarcinoma [3] while 1 patient had leiomyo-sarcoma. Treatment offered included resection of small gut in 7 patients and ileo-colectomy in 3 patients. Three patients with lymphosarcoma had a full course of cytotoxic chemotherapy. The outcome was poor; 2 patients were alive after 3 years, 3 died within 6 months of surgery while the rest were lost to follow-up at variable periods after surgery. Neoplasms of the small gut presents late in our environment. Lymphosarcoma seems commoner in childhood and carries a better prognosis.

Adolescent↗
PubMed1983

[Synthesis and antitumor properties of carminomycin 13-cyclohexylidenhydrazone].

Carminomycin 13-cyclohexylidenhydrazone (CCH) was prepared by interaction of carminomycin 13-hydrazone with cyclohexane. The antiblastomic properties of CCH were studied on mice with transplantable tumors. The preparation was administered intravenously or orally. The studies showed a high antitumor activity of CCH. When CCH was administered intravenously to mice with lymphosarcoma LIO-1, the antitumor effect selectivity of it was practically equal to that of carminomycin. When used in doses equivalent by their toxicity to those of carminomycin, CCH had practically the same inhibitory effect on sarcoma 180 as carminomycin. When used orally in doses equivalent by their toxicity to those of carminomycin, CCH was more effective than carminomycin in treatment of mice with lymphosarcoma LIO-1, sarcoma 180 and lymphadenosis NK/Ly.

Administration, Oral↗
PubMed1976

A preliminary study in treatment of non-Hodgkin's lymphoma by whole-body irradiation.

Seven cases of generalised non-Hodgkin's lymphomas (lymphosarcoma, giant follicular lymphoma and reticulum cell sarcoma) were treated by whole-body irradiation as a preliminary study in this centre. Historical background, rationale, treatment technique, and results of such treatment are discussed in this paper. All patients responded, two completely, and five partially. A multicentre clinical trial is recommended to evaluate the results of whole-body irradiation in comparison with chemotherapy in generalised non-Hodgkin's lymphomas.

Aged↗