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At least 397 records · Page 22Linked to original sources
PubMed1965

LINCOMYCIN AND STAPHYLOCOCCAL INFECTIONS: A CLINICAL STUDY OF 18 CASES.

Lincomycin, a chemically new antibiotic effective against Gram-positive organisms, was evaluated in vitro and tested clinically. In vitro testing indicated that lincomycin is especially effective against Staphylococcus aureus. Clinical testing showed that lincomycin was free of toxicity in a series of 18 cases of staphylococcal infection. Of particular interest was its pronounced effectiveness in nine cases of chronic osteomyelitis, one of which was of 15 years' duration and unresponsive to all other forms of antibiotic and surgical treatment. The only side effect noted was loose stools in the occasional patient.

Abscess↗
PubMed1981

[Effect of intramammary vaccination on experimental staphylococcal infection (author's transl)].

A commercial vaccine for intramammary inoculation to prevent staphylococcal mastitis was tested under experimental conditions. Groups of cows which were vaccinated in all four quarters, in two quarters in the dry period and which were not vaccinated respectively were challenged intramammary with a mixture of alpha, beta, alpha + beta, haemolytic strains of Staphylococcus aureus during lactation. After challenge, severe mastitis developed in most cows. Unlike cows in the half- and non-vaccinated groups, the vaccinated cows did not show a rise in body temperature. The anti alpha-haemolysin titre in the serum was higher in the vaccinated than that in the non-vaccinated group but after challenge this difference was reversed. The half-vaccinated group showed titres which were between those of the other two groups. This experiment does not suggest that vaccination offers substantial advantages in acute staphylococcal mastitis. Besides having a beneficial effect on milk production, vaccination prevents fever, which is a useful phenomenon as regards the clinical picture as a whole.

Animals↗
PubMed1980

Dicloxacillin and flucloxacillin twice daily with probenecid in staphylococcal infections. A clinical and pharmakokinetic evaluation.

The therapeutic efficacy of decloxacillin or flucloxacillin, 1--2 g orally with probenecid twice daily was evaluated in staphylococcal infections. Excellent results were obtained with this as long-term maintenance therapy in 4 patients with relapsing chronic osteomyelitis and in 6 patients with postoperative infections. No side effects were observed in these patients. In 35 patients with furunculosis twice daily administration of dicloxacillin was used as a primary therapeutic regimen. All healed, but 4 recurrencies occurred during a 3-month observation period after therapy. In 5 patients allergic reactions were noted. The unbound fraction of flucloxallin in serum exceeded MIC values of methicillin-susceptible Staphylococcus aureus during 11 of 24 h. Pharmacokinetic data on flucloxallin with and without probenecid are given.

Cloxacillin↗
PubMed2006

Analysis of genetic diversity among Staphylococcus aureus isolates from patients with deep-seated and superficial staphylococcal infections using pulsed-field gel electrophoresis.

Molecular typing was performed to reveal the genetic diversity among Staphylococcus aureus strains causing deep-seated versus superficial staphylococcal infections. Pulsed-field gel electrophoresis with cluster analysis, plasmid and antimicrobial susceptibility profiling of 50 S. aureus strains collected from these 2 groups of patients were undertaken. A total of 19 (designated A through S) distinct genotypes were identified by PFGE of Sma I-digested genomic DNA. The most prevalent PFGE type was L, which accounted for 30% of isolates and was detected among superficial isolates only. The second most prevalent PFGE type, type A (18%), was predominant among deep-seated isolates. Remaining PFGE types varied in distribution between the 2 groups. Plasmid profile analysis revealed that deep isolates harbour plasmids more frequently (comprising 64% of isolates) than superficial isolates (4%) and showed 10 and 2 distinct patterns, respectively, with pattern 1 being the dominant among deep isolates. Antimicrobial susceptibility data suggested an increased prevalence of antibiotic resistance among deep isolates with the majority (40%) exhibiting identical antibiograms compared to superficial isolates. No resistance was detected against clindamycin and vancomycin. The results of our study indicate a previously unrecognized dichotomy of S. aureus strains, causing deep-seated and superficial infections.

Adolescent↗
PubMed2006

INH-A21: a donor-selected Staphylococcal human immune globulin for the prevention of late-onset neonatal Staphylococcal infection.

INH-A21 is an experimental human immune globulin for intravenous infusion (IGIV) derived from donors specifically selected for elevated levels of antibodies against the Staphylococcal fibrinogen-binding proteins, serine aspartate dipeptide repeat G and clumping factor A. Phase II results demonstrated that infusions of INH-A21 were well tolerated and there were no trends for increasing adverse events, or the common morbidities associated with prematurity. Enrollment has been completed in (but no results have been released from) a Phase III human trial testing INH-A21 as a prophylactic agent against staphylococcal infection in very low birth weight infants (500-1250 g).

Adhesins, Bacterial↗
PubMed2006

A complex interferon inducer potentiates the functional macrophage activity during Staphylococcal infection.

The antibacterial effect of a new type I interferon inducer, an yeast RNA-tilorone molecular complex (MC), was studied using a model of staphylococcal infection. The MC taken in experimental doses being optimal interferon-inducing ones accelerates the Staphylococcus aureus elimination from mice organisms accompanied by increased functional ability (phagocytosis and bactericide activity) of peritoneal macrophages. The conclusion is that the MC antibacterial activity detected is mediated by its interferon-inducing properties.

Animals↗
PubMed1988

Poor efficacy of teicoplanin in treatment of deep-seated staphylococcal infections.

Teicoplanin in a 400 mg intravenous loading dose followed by 200 mg/day intravenously or intramuscularly was given to 19 patients with deep-seated staphylococcal infections. Only eight patients (44.4%) were considered cured, failure mostly being observed in patients with osteomyelitis, endocarditis and bacteremia. Poor tissue kinetics of teicoplanin and the presence of foreign bodies are probable explanations for the reported failures. Future trials using a higher dose of teicoplanin with or without the addition of rifampicin or gentamicin seem to be justified.

Adult↗
PubMed1991

[The immunomodulating action of the surface antigens of the influenza A virus in experimental staphylococcal infection].

The results of the study of influenza A virus surface antigens, hemagglutinin and neuraminidase, in the induction of nonspecific immunomodulation and protection from acute pulmonary staphylococcal infection have been studied. Protective effect, the cell composition of bronchoalveolar lavage fluid depend on the serological subtypes of surface antigens used for intranasal immunization and the infective dose of staphylococci.

Animals↗