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Results for “CHLORPROTHIXENE”

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At least 415 records · Page 23Linked to original sources
PubMed1981

Effect of single oral doses of various neuroleptic drugs on salivary secretion rate, pH, and buffer capacity in healthy subjects.

The effects of melperone, thioridazine, levomepromazine, and chlorprotixene on salivary secretion rate, pH, and buffer capacity was studied in eight healthy volunteers given single oral doses of placebo or 10, 25, and 50 mg of the drugs in a single-blind crossover design. Both resting and stimulated saliva samples were collected before and every hour for 6h after administration. All drugs reduced secretion rate and lowered pH and buffer capacity, mostly in a dose-dependent manner. The effects of levomepromazine and chlorprotixene were more pronounced than those of melperone and thioridazine.

Adult↗
PubMed2004

In-patient psychiatric-psychotherapeutic treatment of mothers with a generalized anxiety disorder--does the co-admission of their children influence the treatment results? A prospective, controlled study.

INTRODUCTION: Whether women who are admitted together with their children achieve inpatient psychotherapeutic treatment results that differ significantly from the results for women who are admitted alone, is a subject of controversy. We compared both groups in a prospective, randomized, controlled study. METHODS: The monitored results of 29 female patients diagnosed with generalized anxiety disorder, 15 of whom were admitted with accompanying children and 14 without, were compared (response rate 95.3%). The period of observation amounted to six weeks. The System Checklist (SCL-90-R) and The Questionnaire of Changes in Experience and Behavior (VEV) were used as instruments of assessment. RESULTS: With respect to co-morbidity and socio-demographic data, both groups were initially comparable. During the course of six weeks' treatment, no statistically significant differences between the results for mothers with and mothers without accompanying children were measured in any of the tests we used, namely, the VEV (Difference = 0.3; 95%-CI [-5.4; 6.1]; p = 0.66) and the SCL-90-R, which includes the Global Severity Index (Difference = 4.0; 95%-CI [-1.4; 9.4]; p = 0.15), and the Anxiety Scale (Difference = 0.5; 95%-CI [-2.0; 1.0]; p = 0.63). CONCLUSION: The results indicate that mothers with generalized anxiety disorder who were accompanied by their children during in-patient psychotherapeutic treatment achieved treatment results that were just as good as mothers with the same diagnosis who were admitted without children.

Adult↗
PubMed1992

Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal.

Growth hormone (GH), blood pressure, and pulse rate responses to clonidine (100 micrograms IV) were studied three times during the first week of alcohol withdrawal in 19 alcohol-dependent patients. Fifteen healthy men were used as controls. The results suggest reduced sensitivity of the alpha-2-adrenoceptors involved in GH secretion for at least 1 week after the end of alcohol intake. In contrast, very short-lasting subsensitivity was found in the alpha-2-adrenoceptors regulating blood pressure.

Adult↗