PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “CHOLIC ACID”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 415 records · Page 23Linked to original sources
PubMed1977

Preparation of radioactive iodinated cholylhistamine for use in the radioimmunoassay of cholic acid.

A major handicap in the development of simple and accurate radioimmunoassay procedures for bile acids has been the lack of a radioactive standard of high specific activity. To provide such a compound, we first synthesized cholylhistamine using the carbodiimide reaction. The hypothesized structure was confirmed by elemental analysis, thin-layer chromatography, infrared and mass spectral analysis. The cholylhistamine was then iodinated with 125I, using the choloramine-T method. The 125I-cholylhistamine was bound by antisera raised against a cholic acid-bovine serum albumin conjugate. This procedure should prove useful in preparing radioactive conjugates for all of the bile acids.

Cholic Acids↗
PubMed1953

Observations concerning the production and excretion of cholesterol in mammals. IX. The mechanism of the hypercholesteremic effect of cholic acid.

Accumulation of cholate in plasma is the immediate cause of hypercholesteremia in the rat with bile duct ligation and in the normal rat given intravenous sodium cholate. The hypercholesteremia induced by cholate administration does not appear to be dependent upon any preceding change in the rates of absorption, excretion, synthesis, or redistribution of cholesterol in the tissues of the animal. Cholate administration seems to induce hypercholesteremia by impeding the normal rate of passage of cholesterol from the plasma into the liver; this impedance is probably due to an alteration of the cholesterol-binding power of plasma proteins induced by cholate. The chemical and physiological implications of this finding are discussed.

Animals↗
PubMed1977

[Action of the microbial flora of the digestive tract on the biosynthesis of cholic acid in the rat (author's transl)].

Axenic and holoxenic (conventional) rats were fed a diet containing trace amounts of [2,4-3H]cholic and [24-14C]chemodeoxycholic acids. In the feces of both groups of rats, the percentage of labelled bile acids which were 3H-labelled was slightly different. In the experimental conditions used, the intestinal microflora only slightly modified the synthesis of 12alpha-hydroxylated bile acids.

Animals↗