The effectiveness of speech training techniques based on operant conditioning: a comparison of two methods.
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Auditory Perception↗
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Preoperative grading system for predicting operative conditions in laparoscopic cholecystectomy.
PURPOSE: In a previous retrospective study, we predicted the operative conditions for abdominal wall-lifting laparoscopic cholecystectomy (ALLC), using a new preoperative grading system. We conducted the present study to evaluate the validity of our grading system prospectively, and to improve the operative outcome. METHODS: Ninety-seven patients underwent cholecystectomy between January 2000 and March 2002, and were prospectively examined according to our preoperative grading system. Allotting 0-5 points for nine preoperative factors, the total combined score was defined as the predictive score. The postoperative score was defined by allotting 0-8 points to five operative factors. The ratio of the preoperative score / postoperative score was defined as the skill score. RESULTS: The mean postoperative score was significantly correlated with the predictive score (P < 0.01). The mean operation time and the mean postoperative score differed significantly among surgeons with skill scores higher or less than 1.25 (P < 0.05). They were significantly improved (P < 0.05) by choosing an operator according to the predictive score and skill score. CONCLUSION: Our preoperative grading system using the predictive score is a valid method of predicting the actual operative conditions of ALLC. An adequately skilled operator should be chosen according to the difficulty of each case, to ensure the best possible operative outcome.
Aged↗
Classical and operant conditioning differentially modify the intrinsic properties of an identified neuron.
A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify the intrinsic excitability of neuron B51, a critical element for the expression of the feeding response, thus revealing that these two forms of associative learning differ at the cellular level.
Animals↗
Operant conditioning of the short-latency cervical somatosensory evoked potential in quadriplegics.
Operant conditioning of short-latency cervical somatosensory evoked potentials (CSEP) was demonstrated in five cervical cord injury subjects. Subjects were conditioned to augment the N14 potential, thought to originate from the dorsal column nucleus. Increased N14 potential was associated with an increase in N19 and P22 potentials, and either a decrease (base) or no change (train) in the brachial plexus potential. The N19 potential was correlated with significant reductions in the sensation-twitch (S/T) ratio during conditioning sessions, indexing improved sensation to low-intensity percutaneous stimulation. Moreover, S/T ratios decreased significantly during conditioning sessions, and were reduced significantly relative to initial baseline values. The results do not appear to be associated with trivial mediating influences.
Adult↗
Modification of human gastric acid secretion with operant-conditioning procedures.
In an attempt to control gastric acid secretion with operant-conditioning techniques, four normal women were given visual feedback on gastric pH plus money reinforcers. When money was made dependent on increased secretion in a differential-reinforcement-of-high-rates schedule, the rate of secretion of three of the four subjects increased to three times baseline. When money was then made dependent on decreased secretion in a differential-reinforcement-of-other-behaviors schedule, the rate of secretion of these three subjects returned to baseline levels. Heart rate, respiratory frequency, abdominal electromyographic activity, and stomach motility (measured by the electrogastrogram method) were not consistently correlated with acid secretion across subjects, although individual subjects showed substantial correlations between acid secretion and one or more other physiological response.
Adult↗
Operant conditioning of primate spinal reflexes: the H-reflex.
The study of primate memory substrates, the CNS alterations which preserve conditioned responses, requires an experimental model that fulfills two criteria. First, the essential alterations must be in a technically accessible location. Second, they must persist without input from other CNS regions. The spinal cord is the most technically accessible and readily isolated portion of the primate CNS. Recent work has demonstrated that the spinal stretch reflex (SSR), the initial, wholly segmental response to muscle stretch, can be operantly conditioned and suggests that this conditioning may produce persistent spinal alteration. The present study attempted similar operant conditioning of the H-reflex, the electrical analog of the SSR. The primary goals were to demonstrate that spinal reflex conditioning can occur even if the muscle spindle is removed from the reflex arc and to demonstrate conditioning in the lumbosacral cord, which is far preferable to the cervical cord for future studies of neuronal and synaptic mechanisms. Nine monkeys prepared with chronic fine-wire triceps surae (gastrocnemius and soleus) electromyographic (EMG) electrodes were taught by computer to maintain a given level of background EMG activity. At random times, a voltage pulse just above M response (direct muscle response) threshold was delivered to the posterior tibial nerve via a chronically implanted silicon nerve cuff and elicited the triceps surae H-reflex. Under the control mode, reward always followed. Under the HR increases or HR decreases mode, reward followed only if the absolute value of triceps surae EMG from 12 to 22 ms after the pulse (the H-reflex interval) was above (HR increases) or below (HR decreases) a set value. Monkeys completed 3,000-6,000 trials/day over study periods of 2-3 mo. Background EMG and M response amplitude remained stable throughout data collection. H-reflex amplitude remained stable under the control mode. Under the HR increases mode (5 animals) or HR decreases mode (4 animals), H-reflex amplitude (EMG amplitude in the H-reflex interval minus background EMG amplitude) changed appropriately over at least 6 wk. Change appeared to occur in two phases: an abrupt change within the first day, followed by slower change, which continued indefinitely. Change occurred in all three triceps surae muscles (medial and lateral gastrocnemii and soleus). Under the HR increases mode, H-reflex amplitude rose to an average of 213% of control, whereas under the HR decreases mode it fell to an average of 68% of control. The results demonstrate that the H-reflex can be operantly conditioned.(ABSTRACT TRUNCATED AT 400 WORDS)
Animals↗
Pain report and pain-related evoked potentials operantly conditioned.
OBJECTIVE: The purpose of the present study was to answer the question whether pain report can be increased and decreased by operant conditioning. We predicted that the conditioned pain effects would remain significant after correction for social desirability and fantasy proneness. Furthermore, we tried to show that the neurophysiologic basis of verbal pain report, defined by pain (event)-related potentials, was affected by the conditioning procedure. Specifically, it was expected that the central recording site N150-P260 pain (event)-related potentials peak-to-peak amplitude would show the largest effect. METHODS: There were 4 groups: an up-conditioning group, a down-conditioning group, an at-random conditioning, and no-feedback control group. Healthy patients received 45 calibrated pain stimuli of equal physical intensity and were asked to rate the pain intensity they experienced. Up-conditioning was established by rewarding the subject if pain report increased compared with the previous trial. Down-conditioning of pain report was achieved by rewarding a decrease in the pain score. RESULTS: Results of the subjective pain reports clearly indicated that both forms of conditioning succeeded. Up-conditioning resulted in the highest pain scores and down-conditioning in the lowest scores with the two control groups in between them. Controlling for level of social desirability and fantasy proneness did not negatively influence these results. The N150-P260 pain (event)-related potentials peak-to-peak central recording site component also showed the predicted effect and reached statistical significance. DISCUSSION: We concluded that the subjective report of pain as well as a specific pain-related potentials component can be operantly conditioned.
Adolescent↗
Mechanism for testing operant conditioning and body rocking in developmental disabilities.
A mechanism is described for testing operant conditioning and body rocking in developmentally disabled persons. The system is made up of a reinforcement dispenser, a lever-pulling mechanism, and flexible chair back for testing body rocking. Experience with the system has shown it to be sturdy and reliable, and the reinforcement dispenser to be adaptable to a wide range of food preferences.
Conditioning, Operant↗
Operantly conditioned motoneuron plasticity: possible role of sodium channels.
1. Learning is traditionally thought to depend on synaptic plasticity. However, recent work shows that operantly conditioned decrease in the primate H reflex is associated with an increase in the depolarization needed to fire the spinal motoneuron (VDEP) and a decrease in its conduction velocity (CV). Furthermore, the increase in VDEP appears to be largely responsible for the H-reflex decrease. The conjunction of these changes in VDEP and CV suggests that an alteration in Na+ channel properties throughout the soma and axon could be responsible. 2. A mathematical model of the mammalian myelinated axon was used to test whether a positive shift in the voltage dependence of Na+ channel activation, a decrease in Na+ channel peak permeability, or changes in other fiber properties could have accounted for the experimental findings. 3. A positive shift of 2.2 mV in Na+ channel activation reproduced the experimentally observed changes in VDEP and CV, whereas a reduction in Na+ channel permeability or changes in other fiber properties did not. 4. These results are consistent with the hypothesis that operantly conditioned decrease in the primate H reflex is largely due to a positive shift in the voltage dependence of Na+ channel activation. Recent studies suggest that change in activation of protein kinase C may mediate this effect.
Action Potentials↗
Effect of operational conditions on membrane permeability in a coagulation-microfiltration process for water purification.
A coagulation-microfiltration combination process was used in treatment of simulative surface water. The effects of operational conditions such as filtration time, ceasing time and aeration intensity on the membrane permeability and organic removals were investigated. Experiment results showed that the membrane permeability could be improved through changing the operational conditions. Decreasing the filtration time or increasing the ratio of filtration time/ceasing time was favorable to enhance the membrane permeability. As the aeration intensity increased, the membrane permeability was also enlarged to some extent, but was not improved obviously anymore when the aeration intensity was over the critical value of around 4m3h(-1). Different wash methods to remove membrane fouling were attempted. The results suggested that coagulation in the process mainly led to change of the deposit cake-caused membrane fouling, which could be physically removed by surface wash. Organic removals, in terms of OC and UV254, apparently varied with the operational conditions. An inverse relationship between organic removals and membrane permeability was found. Lower membrane permeability led to higher OC and UV254 removals.
Filtration↗
[Application of operant conditioning techniques to forensic toxicology: experimental studies on alcohol and abusable drugs].
This paper describes some experiments that apply the operant conditioning techniques to forensic toxicological research. These techniques may be useful in investigating the mechanisms of action, toxic symptoms, legal competence and drug metabolism associated with substance abuse such as abuse of alcohol, psychotropic drugs, narcotics, stimulants, and organic solvents. 1) Genetic research on alcohol preference in rats. We applied operant conditioning to investigate alcohol preference in rats and constructed an apparatus for the measurement of discriminated operate responses for water or alcohol reinforcement in rat. This apparatus is a modified Skinner box with a one-lever two-liquid system. Fixed ratio-10 (FR-10) schedules of reinforcement are used to increase the work of the rat before it obtains the reinforcement. The voluntary choice of water or 10% ethanol by the rat can be assessed quantitatively by measuring the lever-pushing responses. It is an extremely useful method for measuring the real alcohol preference of rats. A rat was kept in a Skinner box overnight. The numbers of responses and reinforcement for water and ethanol and the volumes of the two liquids consumed were recorded. The ratio of ethanol reinforcement was defined as the number of ethanol reinforcement to the total number of ethanol and water reinforcement. The ratio of ethanol intake was defined as the volume of ethanol consumed to the volume of water and ethanol consumed. Ethanol consumption per g body weight was calculated from the volume of ethanol consumed by the rat. We used this apparatus to investigate alcohol preference of more than 300 Wistar Albino Rats, and divided them into a high alcohol preference (HAP) group and a low alcohol preference (LAP) group. Inbreeding between littermates was conducted in each of the HAP and LAP groups. The liver tissue of each offspring was obtained and the cytosol fraction was collected and subjected to isoelectric focusing using polyacrylamide gel with a pH range of 3.5 to 9.5. Examination of the electrophoretic patterns of the acetaldehyde dehydrogenase (ALDH) revealed polymorphism in cytosolic ALDH 1. We confirmed that the polymorphism follows Mendel's law of inheritance, and is governed by two codominant alleles. Moreover, the polymorphism of ALDH 1 observed in Wistar strain rats correlated closely with the differences in ethanol consumption behavior or alcohol preference. 2) Effects of abusable drugs on learning behavior of rat. In general, animal experiments for assessing drug effects, regardless whether they measure learning or intrinsic motor or physiological function, use behavioral indicators that produce a positive or negative reinforcement. In other words, the behavioral effect of a drug is assessed by whether it enhances the animal's behavior in a positive reinforcement or decreases its response in a negative reinforcement. However, the behavioral indicator of the animal is rarely an independent entity within the body, but is closely associated with other behavioral components. Even when a behavioral indicator is enhanced by a drug, whether the apparent increase is due to the enhancing effect of the drug or a result of decreases of other behavioral components cannot be judged. We therefore devised a multiple active/passive avoidance learning apparatus which is a device for analyzing drug effects in rats using a running-wheel. We used this device to assess the effects of a drug on the animal from three dimensions simultaneously; excitatory, inhibitory and discriminatory behaviors. From these we attempted to clarify the overall effect of the drug on high order learning behavior of animal. This method enables direct examination of the so-called "learning capability" of an animal, which cannot be elucidated by single scheule learning that is strongly influenced by behavioral characteristics such as excitation and inhibition. Therefore, a method which uses avoidance learning as indicator is the best method
Aldehyde Oxidoreductases↗
EEG operant conditioning in a monkey model: II. EEG spectral analysis.
EEG power spectral analysis was studied from 14 (alumina-gel) chronically epileptic, undrugged monkeys during an EEG operant conditioning experiment. The composite profile of the average epileptic monkey shows the majority of power to be below 10 Hz. Because of the large variance in the data, no significant changes in the EEG power spectra could be detected as a function of conditioning. The possible reasons for this large variance are discussed. Hypothesis from previous human "biofeedback" studies would allow the prediction that those frequencies corresponding to the mu and sensory-motor-rhythm should negatively covary with seizure frequency. Data from this study did not support such assertions. The method of using spectral analysis for quantifying changes in the EEG which covary with operant conditioning is evaluated.
Animals↗
A new preoperative grading system for predicting the operative conditions for abdominal wall-lifting laparoscopic cholecystectomy.
PURPOSE: This study was performed to evaluate the operative conditions for an abdominal wall-lifting laparoscopic cholecystectomy (ALLC) using a new preoperative grading system. METHODS: One hundred forty-five patients who underwent a cholecystectomy for cholecystolithiasis from January 1997 to December 1999 were retrospectively analyzed. Allotting 0-5 points for coexisting cholecystitis, past history, previous upper abdominal laparotomy, preoperative drainage, location of the stones, and body mass index, the total combined score was defined as the predictive score. The cases were graded into four risk groups according to the predictive score. The postoperative score, which evaluated the actual conditions of ALLC, was defined by allotting 0-8 points to operative factors: operation time, blood loss, additional trocars and procedures, conversion to open surgery, and postoperative complications. RESULTS: Ten cases (6.9%) were converted to open surgery and three cases (2.1%) had minor postoperative complications. The conversion rate for each risk group was 0% (minimum-risk group), 5.4% (low-risk group), 10.7% (intermediate-risk group), and 17.9% (high-risk group). The mean operation time was 63.0, 87.5, 89.0, and 120.2 min. The mean postoperative score was 1.08, 2.81, 3.96, and 6.36, and showed a respectively strong correlation with the predictive score (correlation coefficient: 0.997). CONCLUSIONS: Our preoperative grading system using the predictive score was found to be a reliable and feasible method for predicting the actual operative conditions for ALLC.
Analysis of Variance↗
Motoneuron plasticity underlying operantly conditioned decrease in primate H-reflex.
1. Monkeys can gradually increase or decrease the size of the triceps surae H-reflex in response to an operant conditioning task. This conditioning modifies the spinal cord. To determine the location and nature of the spinal cord plasticity and define its role in the behavioral change (i.e., H-reflex increase or decrease) we have recorded intracellularly from triceps surae motoneurons in conditioned animals and compared the results with data from naive (i.e., unconditioned) animals. 2. Eleven monkeys (Macaca nemestrina, male) were exposed to the HRdown conditioning mode, in which reward occurred when H-reflex size in one leg (i.e., the trained leg) was below a criterion value. In six animals (5.1-8.2 kg) H-reflex size in the trained leg fell to 24-58% of its initial value, whereas in the other five animals (4.0-5.5 kg) it remained at 92-114% of its initial value. This outcome, which was in accord with recent data indicating that success in HRdown conditioning is age dependent, allowed comparison of intracellular data from successful HRdown animals with data from unsuccessful animals as well as with data from naive (i.e., unconditioned) animals. 3. Intracellular recordings were obtained from 221 triceps surae motoneurons on trained and control sides of successful and unsuccessful HRdown animals. Measurements included axonal conduction velocity, input resistance, time constant, electrotonic length, rheobase, firing threshold, afterhyperpolarization duration and amplitude, and composite homonymous and heteronymous excitatory postsynaptic potentials to peripheral nerve stimulation. Results were compared with data from 109 triceps surae motoneurons in naive animals. 4. Motoneurons from the trained side of successful HRdown animals had a significantly more positive average firing threshold (-52 vs. -55 mV) and a significantly lower average conduction velocity (67 vs. 71 m/s) than those from naive animals. In contrast, motoneurons from the trained side of unsuccessful HRdown animals were not significantly different from naive motoneurons. 5. These data are consistent with the hypothesis that operantly conditioned decrease in H-reflex size is due to a positive shift in motoneuron firing threshold and a consequent increase in the depolarization needed to reach that threshold. 6. The more positive firing threshold, if present in the axon as well as in the soma, could also account for the decreased conduction velocity observed in motoneurons from the trained side of successful animals.
Animals↗
Operant conditioning of trigeminally-evoked cortical potentials: correlated effects on facial nociception.
The effects of operant conditioning somatosensory evoked potential (SEP) amplitude on nociceptive sensitivity were studied in albino rats. SEPs were evoked by stimulation to the descending trigeminal tract. Rewarding medial forebrain bundle stimulation (at intensities predetermined to sustain bar pressing) was made contingent upon the animal making the amplitude of the SEP 0.5 standard deviation (S.D.) large (uptraining) or 0.5 S.D. smaller (downtraining) than the predetermined mean value. Nociceptive sensitivity was measured immediately following the conditioning session by heating the rat's face and noting the latency of a defensive face rubbing response directed at that area of the face. Increasing the amplitude of the SEP (uptraining) was associated with a decrease in noxious sensitivity. Decreasing the amplitude of the SEP (downtraining) was associated with an increase in noxious sensitivity.
Animals↗
Operant conditioning in relation to natural EMG during rapid human walking.
Interactions between specific operant conditioning and ongoing treadmill walking have been characterized in several previous investigations of mechanisms that coordinate locomotion. The present study examined a higher walking velocity in which contractile forces and, by inference, reflex behavior, might be more powerful. Two subjects walked on a motor-driven treadmill at 0.90 m/sec. As in past work, at 0.45 m/sec, a conditioning regimen constructed a test operant in the following way. With training, a green light that flashed approximately 200 msec after heel strike on every third step produced, after operant reinforcement, a 100-500 msec electromyographic burst in the rectus femoris (RF) muscle before the end of a 500 msec performance duration. Reinforcement consisted of a tone that sounded after each response and indicated success or failure. Burst durations were shorter than had been typical at a lower treadmill speed, a characteristic that could favor rapid matching of contractile patterns to more rapidly changing conditions. No evidence was gained of interference from stretch reflexes or any other ongoing inborn behavior. The resulting rapid walk was as well coordinated as that seen at lower velocity, to argue for increased emphasis on the role of learning in normal locomotion and to improve pathological walking.
Adult↗
Alterations in the visual cortex receptor pattern by operant conditioning in a reward paradigm.
The aim of the study was to investigate the impact of operant conditioning on the receptor pattern in the visual cortex of calves. A reward paradigm was used to induce conditioned preference for colours. Binding sites in visual cortex specimens from conditioned and naive animals were assayed in vitro on cellular basis after dissociation of the tissue by collagenase, incubation with fluorescent ligands and flow-cytometry for fluorescence analysis. The cellular counts were subdivided according to sedimentation at 200 g as well as via the flow-cytometrical histogram by size and granularity. Binding sites of dopamine D1 and D2 receptor subtypes, glucocorticoids, opioids, casein as well as glycine and N-methyl-D-aspartic acid (NMDA) were detected by fluorescent molecular probes. In displacing naloxone fluorescein from NMDA- and mu-opioid receptors NMDA and meth-enkephalin were used. Comparisons between portions of fluorescent cellular counts from visual cortex tissue of conditioned and naive animals revealed a small increase (1.2-fold, P < 0.05) in opioid receptors of large and high granulated counts, bearing > 80% D1 receptors, and a decrease (0.70-fold, P < 0.05) in less granulated counts with variable portion of D1 receptors. Conditioning resulted in higher and lower displacing rates by meth-enkephalin and NMDA, resp., and in a reduce in counts with dopamine D1 (0.8-fold, P < 0.05), glycine and glucocorticoid binding sites (0.6-fold in both cases, P < 0.01). A tendency of elevated phagocyte marker expression occurred in high granulated counts. The data suggest that conditioning is accompanied with significant and in part marked change in binding sites studied. Induction of scavenger activity may parallel this process. As cellular portion with glycine and glucocorticoid receptors were most markedly altered by conditioning, the neurochemical needs of the used paradigm seem to focus to motility-related functions.
Animals↗
Operant conditioning of EMG activity using cigarette puffs as a reinforcer.
This study was a test of an operant conditioning model of cravings. The model posits that smoking or opportunity to smoke may reinforce physiological reactions to cigarette deprivation that are typically labeled as cravings. More specifically, the rate and amplitude of a physiological response (EMG activity) can be modified, and brought under stimulus control, using cigarette puffs as a reinforcer. Three adult smokers, who were deceived as to the purpose of the study, served as subjects. Three subjects were exposed to two conditions: baseline and response-contingent tone and puff. A single subject reversal design was used. Two of the three subjects showed conditioning effects with the mean level of EMG responding and rate of criterion responding in the response-contingent condition exceeding baseline levels of responding. For one of these subjects, two additional control conditions were used. Responding in the response-contingent condition was higher than in either control condition. The need for replication and extension of the present procedures are discussed.
Adult↗