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At least 415 records · Page 23Linked to original sources
PubMed1989

Histologic changes in dog lymph nodes after endolymphatic application of bleomycin oil suspension.

Bleomycin oil suspension (Oil-Bleo) was injected endolymphatically in a dog experiment. The drug remained in lymph nodes over many weeks in detectable concentrations. The histologic changes in these lymph nodes were examined and compared with 3 controls (aqueous Bleomycin, Lipiodol, and no treatment). Granulomatous reaction, microabscesses, and small necrotic foci were observed. After a month, fibrosis was detectable in all lymph nodes. The damage to microscopic lymph node structures after Oil-Bleo was moderate. These findings suggest that Oil-Bleo may be useful in local treatment of lymph node metastases.

Animals↗
PubMedDate not supplied

[Retrospective evaluation of the efficacy of regional endolymphatic polychemotherapy in kidney cancer depending on the histologic structure of the tumor].

An attempt was made to differentiate the prognosis for patients with various histological patterns of renal cell carcinoma subjected to adjuvant regional endolymphatic polychemotherapy from those patients who were not. A total of 90 patients were allocated to 3 groups: the first group consisted of those persons for whom a 4-component endolymphatic therapy with 5-fluorouracil, cyclophosphamide, methotrexate, thiotepa was employed; the second group (25 patients) was administered the same preparations intravenously; the third-group patients (25 subjects) were those who after surgery were not given drugs at all. Tumor biopsy specimens were studied in detail histologically and 3 carcinoma patterns were distinguished: clear cell, granular cell and anaplastic carcinoma. The number of mitotic figures per 1,000 tumor cells was defined as well. The life-span of all anaplastic carcinoma patients was less than 5 yrs. Three-year survival was the most common in first group patients with clear cell or granular cell carcinomas. Five-year survival in patients with granular cell carcinoma was 50 per cent in the first and 11.1 per cent in the second group, while in those with clear cell carcinoma it was relatively equal in all groups. The total five-year survival rate was 40 per cent in group I, 20 per cent in group II and 16 per cent in group III. The results obtained were indicative of a higher effect of adjuvant endolymphatic polychemotherapy versus intravenous treatment. As better results were in those with granular cell carcinoma than in patients with clear cell carcinoma, tumor histological pattern be considered before the adjustment of cytostatic dosages and disease prognostication.

Adult↗
PubMed1989

Retroperitoneal lymph nodal visualization using 30% Guajazulen blue (chromolymphography).

Guajazulen, a dark blue lipid-soluble dye was used to stain retroperitoneal lymph nodes before lymphadenectomy. Initially, a 30% solution of Guajazulen (Merck, Darmstadt, FRG) in iodinated oil (Lipiodol, Byk-Gulden, Konstant, FRG) was injected endolymphatically in the hindlimbs of pigs (n = 10) and dogs (n = 8) to better visualize retroperitoneal lymph nodes. Because of encouraging results, 11 patients with testicular cancer undergoing staging or therapeutic laparotomy underwent endolymphatic injection of this dye solution preoperatively. The excellent staining of retroperitoneal lymph nodes facilitated nodal selectivity during lymphadenectomy.

Animals↗
PubMed1989

[Thoracic duct collaterals of lymphatic and pulmonary origin. Anatomy and chylothorax after pulmonary surgery].

Dye injection of lung segments reveals the existence of lymphatic drainage of the lungs generally into cervical venous confluents and more rarely into the arch of the thoracic duct in the neck and also occasionally into the thoracic duct in the mediastinum. Direct drainage of the lymph into the thoracic duct was observed in 10 cases out of a series of 589 injections of lung segments in adult cadavers. In one half of cases, the thoracic duct was injected from the left suprabronchial lymph node chain, the origin of the left recurrent chain, and in one quarter of cases from the lateral anteroposterior right major azygos and left azygo-aortic lymph node chains, not recognised by the classical authors. More rarely, direct lymphatic collaterals drained certain segments of the lower lobes into the thoracic duct via the triangular ligament. Analysis of cases of chylothorax occurring after lung resection and observed in the authors' department or in the literature reveals that most of them can be attributed to a chyle leak from one of these pulmonary lymph collaterals. These pathways are probably also involved in the development of medical or idiopathic chylothorax.

Adult↗
PubMed1989

[Direct endolymphatic administration of antitubercular drugs in patients with inflammatory diseases of the urogenital organs].

Direct endolymphatic administration of broad-spectrum antibiotics was used in treatment of approximately 21 patients with complicated urogenital tuberculosis. The duration of the endolymphatic therapy ranged from 3 to 13 days. In the patients treated with endolymphatic administration of the antibiotics the effects were favourable. The use of the procedure were shown expedient because marked lesions in the urinary tracts, frequent chronic renal failure and the microbial flora resistance to the drugs lowered the efficacy of the treatment with the routine administration of the drugs. The drugs used i.e. klaforan and gentamicin were approved by the USSR Pharmacological Committee. The drugs were administered with dosator NDL-3 in original modification which provided continuous polycollector endolymphatic antibiotic therapy with simultaneous lavage of the lymphatic channel. It was shown expedient to use endolymphatic administration of antibiotics in treatment of complicated urogenital tuberculosis alone or in combination with the preoperative procedures.

Antitubercular Agents↗
PubMed1989

[Endolymphatic antibiotic therapy of allergic vasculitis].

Inadequacy of the routine methods for therapy of infectious allergic vasculitides and the necessity of sanitizing the foci of infection have prompted the application of endolymphatic administration of antibiotics. Studies of ampicillin pharmacokinetics have demonstrated that a single endolymphatic injection in a dose of 1 x 10(6) U is sufficient to maintain the therapeutic concentration of the drug in the blood serum for 24 hrs. Ampicillin has been injected into the lymph vessels of both soles in the above dose once daily for 5-7 days to 10 patients suffering from allergic vasculitis for a long time. The pathologic elements regressed by the end of the course of therapy in all the cases; only two patients have developed relapses in several months, that have been rapidly arrested.

Adult↗
PubMed1989

[Experience with the use of endolymphatic antibacterial therapy].

In 98 patients with different purulent-inflammatory processes, the method of antegrad endolymphatic antibacterial therapy was used in the complex of treatment. One of the antibiotics (ampicillin, gentamycin, claforan), and metrogyl, dioxydin, contrical, heparin at the routine therapeutic doses 1 time at 24-48 h were introduced into the lymphatic vessel of the lower extremity via a catheter. The duration of treatment depended on the severity of the course of inflammatory process. In 74.4% of cases, the treatment was effective.

Abdomen, Acute↗
PubMed1989

[Indirect endolymphatic chemotherapy of patients with lymphoma].

Treated were 103 patients with malignant lymphomas (lymphogranulomatosis--87; non-Hodgkin lymphomas--16 patients). The treatment was complex including chemotherapy by means of endolymphatic administration of cyclophosphane, prospidin, methotrexate). The technique may be widely used and may be associated with other treatment methods. The efficacy of the method is substantiated and emphasized.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[Lymphotropic therapy in the combined treatment of pulmonary tuberculosis in children and adolescents].

The validity of the use and the procedure of lymphotropic therapy directed to transport of the main antituberculous drug (isoniazid) to the affection foci via the lymphatic system are presented. The procedure was well tolerated by children and adolescents. A course of 30 injections promoted faster resolution of the specific lesions in the lung tissue and intrathoracic lymph nodes. The procedure is useful in treatment of primary infection. It should be applied 3 months after the start of the treatment when there is a tendency to slow progress of the process.

Adolescent↗