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PubMed1980

[Analysis of the antigeno-immunologic activity of heated leptospirosis vaccine in vaccinees and in an experimental study].

The comparative analysis of the immunological effectiveness of heat-killed polyvalent leptospirosis vaccine has shown the low immunological effectiveness of the whole preparation (17.8%) and its components with the exception of the antigen of the Grippotyphosa serogroup. Antibodies could be detected in the vaccinees for not more than 10 months, and they showed the properties of 19S-macroglobulin antibodies. In experiments on rabbits newly isolated Leptospira strains from human patients and wild rodents, homologous to the vaccinal strains, were found to considerably surpass the latter in their immunogenic properties; this was particularly manifest in strain "Tundra vole No. 180". The use of newly isolated Leptospira strains as vaccinal antigens is recommended. A modified heat-killed polyvalent leptospirosis vaccine should have less antigens, and the antigenic and immunogenic properties of the remaining antigens must be equivalent to those of the vaccinal antigen of Leptospira belonging to the Grippotyphosa serogroup.

Adolescent↗
PubMed1982

[Nucleotide composition and homology of the DNA of parasitic Leptospira].

The study of DNA in parasitic leptospirae of different serovariants by the method of molecular hybridization has revealed two groups differing in their homology level. The homology of nucleic acids has been found to correlate with serological properties. The serovariants ensuring cross immunity are characterized by the high level of homology of their DNA.

Cross Reactions↗
PubMed1981

Studies on the effect of antibiotic substances on leptospires and their cultivation from material with a high bacterial count.

Leptospira species are difficult to isolate from sperm specimens because rapid growth of the contaminant flora will kill the pathogen. The resistance of 5 Leptospira strains to 5 different antibiotics was examined with a view to an inhibition of such contaminant growth. Neomycin (10, 20, 30 mg/l), vancomycin (5, 8, 10 mg/l), nalidixic acid (50, 75, 100 mg/l), streptomycin (5, 8, 10 mg/l) and chloramphenicol (5, 10, 20 mg/l) were added separately to Korthof's culture medium containing rabbit serum. The comparative growth rates of the leptospires were evaluated. Against the control medium, all 5 antibiotics were found to have an adverse influence on the multiplication phase. In conformity with literature data, vancomycin (10 mg/l) and nalidixic acid (50 mg/l) were found to have the lowest effect. In the cases of streptomycin and chloramphenicol, there was a high reduction of the leptospiral count and even a complete lack of multiplication. A combination of vancomycin (10 mg2l) and nalidixic acid (50 mg/l) was used for the recovery of leptospires from porcine sperm. To inhibit a growth of Ps. aeruginosa, 5000 U/l polymyxin B were added. The strongly inhibitory action of polymyxin B on leptospiral growth could be eliminated by subculturing in a medium free from inhibitory substances after 2 days.

Anti-Bacterial Agents↗
PubMed1981

Serological and bacteriological survey of leptospiral infection in pigs in southern England.

A total of 597 pigs were examined for serological and bacteriological evidence of leptospiral infection. The sample comprised 189 porkers, 205 baconers and 203 sows. Sera were tested against 17 antigens from 16 serogroups and the overall prevalence of titres was 15.7 per cent. The lowest prevalence of titres was found in porkers (10.0 per cent). The highest prevalence of titres to an individual antigen was recorded with bratislava, a member of the Australis serogroup, with 12.2 per cent of pigs positive. Copenhageni titres were present in 1.8 per cent of the sera and sporadic titres were recorded to various other antigens. Leptospires were isolated from five pigs. Four isolates were identified as belonging to the Icterohaemorrhagiae serogroup and one to the Hebdomadis serogroup. The serological to bacteriological ratio for the Icterohaemorrhagiae serogroup was 11:4. The virtual absence of titres to pomona and tarassovi, the two serovars most commonly maintained by porcine populations in other countries, confirms the results of earlier serological surveys.

Animals↗
PubMed1981

Leptospirosis experience at Groote Schuur Hospital, 1969-1979.

The diagnosis of leptospirosis requires a high index of suspicion and a knowledge of the wide variety of syndromes with which these patients present. The clinical and laboratory features of 14 patients with leptospirosis seen at Groote Schuur Hospital, Cape Town, between 1969 and 1979 are described.

Adult↗
PubMedDate not supplied

[The use of an indirect immunoenzyme method in the diagnosis of leptospirosis].

Sensitivity and specificity of indirect immunoenzyme method for determining antileptospirosis antibodies have been studied. Supersound antigenic preparations are used as antigens. Determination of genus-specific antibodies and antibodies of more narrow specificity including serogroup specific ones is possible in the elaborated test. A spectrum of revealed serogroup specific antibodies expends in patients with leptospirosis when using polyvalent antigenic preparations.

Antibodies, Bacterial↗