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At least 415 records · Page 23Linked to original sources
PubMed2001

[A case of combined squamous cell carcinoma and aspergilloma arising in a cyst wall].

A 76-year-old man in whom interstitial pneumonia and diabetes mellitus had been diagnosed complained of bloody sputum in August, 1998. Chest radiography disclosed irregular shadows in the left lower lung field. Chest computed tomography (CT) scans revealed a cyst and a small nodular lesion in the left S6 segment. Although primary lung cancer was suspected, we did not detect any malignant cells in the transbronchial lung biopsy specimen. CT scans in January 2000 showed a ball-like shadow in the thick-walled cyst in the left S6 segment. Cytologic examination of the sputum and the bronchial lavage fluid from the left B6 revealed squamous cell carcinoma. Left lower lobectomy and mediastinal lymph node dissection were performed. Pathological examination revealed that moderately differentiated squamous cell carcinoma had extensively invaded the wall of the cyst in the left S6 and S10 segments, and was accompanied with aspergilloma. Abnormal thickening of a cyst wall may in some cases suggest the presence of lung cancer.

Aged↗
PubMed2002

Pulmonary disease in patients with hematologic malignancies.

Patients with hematologic neoplasms frequently experience pulmonary disease. The possibility of a malignant involvement of the lung parenchyma is a well recognized and not unusual event, secondary spread due to lymphoproliferative disorders being the most common situation. Furthermore, the development and the advances in treatment options such as hematopoietic stem cell transplantation, radiation therapy and/or combined drug regimen use have significantly widened the spectrum of non-neoplastic pulmonary complications that can crop up in these patients. Infections, drug/radiation-induced toxicity, and graft-versus-host disease (GVHD)-related complications account by now for most pulmonary problems in hematologic patients and represent a difficult challenge both in diagnostic and in therapeutic terms for the clinician. The aim of this review is to highlight the clinicopathologic spectrum of lung diseases which can occur in the setting of hematologic malignancies. A particular emphasis is devoted to the diagnostic approach, high-resolution computed tomography (HRCT) assuming a key role since different patterns of CT abnormalities are associated with a different yield of the available diagnostic tools and may help in narrowing the differential diagnosis.

Acquired Immunodeficiency Syndrome↗
PubMed1975

Evaluation and management of solitary pulmonary nodules.

The incidence of malignancy in solitary pulmonary nodules found on routine chest roentgenographic survey is unknown but may be as high as 20 per cent. The greatest dilemma confronting most physicians involved in the primary care of patients with solitary pulmonary nodules is sorting out those nodules that can be safely watched from those that should be surgically removed. Certain roentgenographic features of these nodules have been found to be helpful in diagnosis. The only two features that can indicate benign lesions are the presence of dense or concentric calcifications and the stability of the lesion over a period of more than two years. The final decision to operate or not may depend on comparison with old films. Pulmonary nodules present for more than two years without any change in size can be safely followed without operation. Operation is indicated in most newly discovered noncalcified nodules larger than 4 cm and for lesions causing obstructive symptoms.

Calcinosis↗
PubMed2003

[Intra-cavity aspergilloma complicating necrotising sarcoid granulomatosis].

INTRODUCTION: Necrotising sarcoid granulomatosis is a rare clinical entity, characterised by the development of nodular pulmonary opacities, the diagnosis if which is based on the identification of characteristic pathological lesions. CASE REPORT: A 44-years-old male smoker presented with cough and fever. With the exception of a few basal crepitations clinical examination was normal. The chest x-ray showed multiple areas of alveolar consolidation scattered throughout both lung fields, some of which were cavitated. The thoracic CT scan confirmed the presence of cavitating nodules and hilar and mediastinal lymphadenopathy. Samples for mycobacteria were negative. A search for anti-neutrophil cytoplasmic antibodies was negative. Fibreoptic bronchoscopy was normal but transbronchial biopsies revealed giant cells. Lung biopsies taken by video thoracoscopy showed non-caseating granulomata with areas of fibrinoid necrosis and perivascular infiltration with lymphocytes, histology characteristic of necrotising sarcoid granulomatosis. Resolution occurred without treatment. The parenchymal lesions regressed leaving residual cavities. Four years later, following an episode of haemoptysis, the patient was found to have a squamous cell carcinoma (T1N0M0) and aspergillomas in the pulmonary cavities. CONCLUSIONS: Our observation demonstrates that the cavities of necrotising sarcoid granulomatosis may be complicated by aspergillomas.

Adult↗
PubMed1992

[Resection of a mediastinal teratoma that perforated the lung and combined with aspergilloma in the tumor cyst].

We hereby report a rare case of a mature type teratoma that perforated the lung and combined with aspergilloma in the tumor cyst. The patient was a 48-year-old female, who complained of coughing and sputum. The chest roentogenography and chest CT suggested aspergilloma. The patient was operated upon. From the intraoperative and pathological findings, a mature type mediastinal teratoma was found to have perforated the bronchus and lung, and combined with aspergilloma in the cyst of the tumor. The tumor was resected, the drainage bronchus was closed. The mediastinal teratoma and aspergilloma have not recurred for two years and four months since the operation.

Aspergillosis↗
PubMed2004

Disseminated cryptococcosis with pulmonary and marrow involvement mimicking radiological features of malignancy.

The most commonly involved sites of cryptococcosis are the lungs and the central nervous system. Cryptococcal osteomyelitis is a rare complication of disseminated cryptococcosis, and the vertebraes are the most common site of this infection. The most common underlying disease is sarcoidosis, followed by tuberculosis and previous steroid therapy. Conservative treatment alone or treatment with a combination of the medical and surgical curettage is successful in most cases. We report a case of cryptococcal osteomyelitis in a 63-year-old immunocompetent male who presented with lower back pain over the sacral region for several years. Radiologic studies showed a pulmonary mass and a radiolytic lesion involving the left ischial bone, which mimicked pulmonary malignancy with bone metastasis. Biopsy of the lung mass and the bone lesion revealed abundant cryptococcal organisms, and cryptococcal osteomyelitis was diagnosed.

Bone Marrow Diseases↗
PubMed2005

[Pulmonary suture granuloma with Aspergillus after partial resection for lung cancer; report of a case].

We reported an extremely rare case of suture granuloma using monofilament nylon. A 76-year-old female had suffered from cough for 1 month. She had undergone partial resection for pulmonary squamous cell carcinoma 2 years previously. Chest X-ray and computed tomography (CT) detected a mass shadow adjacent to the previous surgical repair, and local recurrence of carcinoma was suspected. Thoracotomy was performed. Incisional biopsy revealed no recurrence sign, therefore partial resection was performed. Histopathological study and bacterial culture resulted suture granuloma with Aspergillus. The granuloma was caused not by foreign body reaction but by transbronchial infection. This case emphasizes that suture granuloma as pseudotumor may be indistinguishable from recurrent cancer.

Aged↗
PubMed2006

[Pulmonary consequences of marijuana smoking].

Based on previously published studies, this review describes the pulmonary consequences of marijuana smoking. Smoking of marijuana is significantly associated with chronic bronchitis (cough and phlegm), but it has not been firmly established whether it also leads to a reduction in lung function. Both epidemiological studies and case reports suggest that regular smokers of marijuana have a higher risk of developing malignancies in both the upper and lower airways. Smoking of marijuana contaminated with fungus spores has been reported to lead to pulmonary aspergillus infections in immunocompromised patients, and sharing of marijuana water pipes has been associated with transmission of tuberculosis.

Acute Disease↗
PubMed2006

Pulmonary blastomycosis masquerading as metastatic disease in the lung: a case report.

We report a case of pulmonary blastomycosis appearing as metastatic laryngeal squamous cell carcinoma. Pulmonary blastomycosis was discovered as right lower lobe subpleural activity consistent with metastatic disease on a positron emission tomographic (PET) scan following total laryngectomy and bilateral neck dissection for locally invasive laryngeal squamous cell carcinoma. A computed tomographic (CT) scan of the chest showed a right lower lobe, subpleural pulmonary nodule. CT-guided fine-needle aspiration of the nodule revealed broad-based budding yeast consistent with blastomycosis. To our knowledge, this is the first case of a PET-positive pulmonary blastomycosis lesion mimicking pulmonary malignancy reported in the literature.

Aged↗
PubMed1991

[A case of pulmonary nocardiosis with squamous cell carcinoma].

A 61-year-old man was admitted to our hospital with cough, bloody sputum, and chest pain. Bronchoscopy showed a tumor in the truncus intermedius which biopsy and brushing cytology revealed to be squamous cell carcinoma. Also, bronchial washings grew only N. asteroides. Treatment with minocycline and trimethoprimsulfamethoxazole (TMP/SMX) over one month resulted in some improvement in pulmonary symptoms and resolution of the infiltrates in the right lower field. Then, right pneumonectomy was performed. N. asteroides was isolated from the resected tumor. Aggressive bacteriological examinations should be utilized when the possibility of pulmonary nocardiosis is considered.

Carcinoma, Squamous Cell↗
PubMed1990

Oral treatment with itraconazole of aspergilloma in cavitary lung cancer.

We report a case of aspergilloma in a necrotic small cell lung cancer, where poor pulmonary function and performance status of the patient precluded surgical treatment. High dose Itraconazole, a new oral anti-mycotic drug, was given for 13 months. During this treatment there was a decrease of the fungus ball size and no haemoptysis. Moreover control of the aspergilloma allowed chemotherapeutic treatment of the underlying bronchocarcinoma.

Antifungal Agents↗