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At least 415 records · Page 23Linked to original sources
PubMed1985

Central anticholinergic syndrome in a child: a case report.

A 2-year-old boy developed classical signs and symptoms of the central anticholinergic syndrome after ingesting twenty 4-mg tablets of the antihistamine cyproheptadine (Periactin). His symptoms were dramatically reversed by the intravenous administration of physostigmine. The physiology of the anticholinergic system and physostigmine are discussed along with the indications, toxicity, and dosing of physostigmine.

Child, Preschool↗
PubMed1977

Regional cerebral blood flow in a case of bromide psychosis.

A case of bromide psychosis is described. A course of repeated measurements of the regional cerebral blood flow (rCBF) was followed, using the 133Xe inhalation method. At the first examination, when the serum bromide level was 45 mmol/1, the cerebral blood flow was reduced to about one-third of the normal. The regional flow pattern was also abnormal with low flows in frontal and parieto-occipital regions. Hemodialysis was performed with an overall improvement of the condition and a successive normalization of rCBF. The pronounced decrease of the cerebral blood flow, together with the positive effects of hemodialysis, seems to indicate that bromide psychosis is of a toxic origin and not an abstinence phenomenon.

Bromides↗
PubMed1986

Carboxyhemoglobinemia caused by inhalation of methylene chloride.

Spray-paint inhalation, once a common and inexpensive source of drug abuse, is now rare. Newer organic solvents, such as methylene chloride, were thought to decrease the toxicity of aerosol solvents, but they carry unique toxicities of their own. Methylene chloride toxicity is difficult to diagnose, as early symptoms are similar to those associated with many intoxicants; however, a rising carboxyhemoglobin level, despite removal of the patient from the source of exposure, is pathognomonic. In dealing with industrial exposures or organic aerosol abuse, a carboxyhemoglobin level should be part of the initial diagnostic workup, and treatment with oxygen is mandatory until toxicity resolves.

Adult↗