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Using the computer to optimize human performance in health care delivery. The pathologist as medical information specialist.

The demands for information retrieval, processing, and synthesis placed on all providers of health care have increased dramatically in the last several decades. Although systems have been developed to capture charge-related data in support of cost reimbursement, there has been a conspicuous lack of attention paid to information tools to directly enhance the delivery of patient care. The termination of cost reimbursement, together with an increasing recognition of the problems inherent in current manual record-keeping systems, is creating a significant new focus on medical information. This change in focus requires a shift in systems orientation away from financial and departmentally centered systems and toward patient-centered approaches. There is thus increasing recognition of the need for a physician-level medical information specialist to serve as an institution's chief information officer, assuming responsibility for the collection, manipulation, and availability of all patient care-related data. By virtue of training, typical experience, hospital presence, and a noncompetitive position with the hospital's medical staff, the pathologist is uniquely suited for this position. To effectively perform this role, a variety of new specialized data management tools are becoming available. Integrated information systems, patient care management by exception, decision support tools, and, in the future, "artificial intelligence" assists can all be expected to become staples of pathology practice, especially impacting those pathologists who choose to be responsive to the new practice milieu of medical information science.

Artificial Intelligence↗

Some characteristics of academic departments of pathology in the United States. Implications for training of academic pathologists.

Data concerning the activities of faculty and various characteristics of academic departments of pathology were obtained from questionnaires returned by 94 chairmen and 1571 faculty members. Data concerning manpower that was the subject of a previous report indicated that the projected supply of MD pathologists for faculty positions was significantly less than the anticipated demand. This article describes the characteristics of academic departments, particularly the activities of faculty that have bearing on the training and expectations of pathologists who are seeking faculty positions.

Academic Medical Centers↗

Antibiotic susceptibility testing accuracy. Review of the College of American Pathologists Microbiology Survey, 1972-1983.

The antibiotic susceptibility testing results for the College of American Pathologists' Microbiology Surveys subscribers for 1981 to 1983 were compared for accuracy and problem areas with earlier data dating back to 1972. Disk diffusion (Kirby-Bauer) test accuracy was 96.3%, 96.4%, and 95.0% for the Bacteriology, Comprehensive, and Basic Surveys participants, respectively. The overall dilution test and automated system (Autobac I) accuracy was 95.8% and 93.8%, respectively. More laboratories (more than 40% of bacteriology and comprehensive laboratories) were using dilution minimum inhibitory concentration tests, usually frozen-form commercial systems. The current test accuracy was comparable with data for previous years, but the Basic Survey subscribers have demonstrated improvement since mid-1981. Several testing problems were identified, principally in the interpretive criteria available in national consensus publications such as the National Committee for Clinical Laboratory Standards M2-A3. Many of these problems have recently been resolved through the cooperation of the National Committee for Clinical Laboratory Standards' subcommittees and the College of American Pathologists' surveys.

Anti-Bacterial Agents↗

Operating room consultation by the pathologist.

Intraoperative consultation by the pathologist should ensure that adequate diagnostic tissue has been obtained, should facilitate the proper handling of tissue, and should provide accurate, prompt histopathologic diagnosis by frozen-section technique. This article discusses the pathologist's role in diseases of the urinary tract, male genital organs, adrenal gland and retroperitoneum.

Adrenal Glands↗

[Principles of the postgraduate training of pathologists in the histological diagnosis of precancer and early forms of cancer].

The following general principles are necessary for achieving the maximum efficiency in the postgraduate training of pathologists in the histological diagnostics of various diseases particularly that of precancer and early forms of cancer: 1) specification of the optimal working classification clinically (prognostically) significant and corresponding to the methodological possibilities of pathologists; 2) use of the most informative diagnostical criteria; 3) formation of visual images of the diagnostical criteria including the stages of transition from the stereometric representation into the plane one, the differentiation between the feature and structural formations that imitate it, elaboration of criteria for the evaluation of the degree of semiquantitative signs; 4) placing the diagnostical criteria in the optimal order; 5) finding the criteria of the correctness of the diagnosis in question. The development of the above criteria is important in teaching, in working out methodological literature and in postgraduate selfeducation.

Cytodiagnosis↗

Separation of small-cell from non-small-cell lung cancer. The Southeastern Cancer Study Group pathologists' experience.

We reviewed the pathology materials from 691 patients with lung cancer who participated in therapy protocols with the Southeastern Cancer Study Group. We found good agreement (94%) between pathologists over the separation of small-cell carcinomas from non-small-cell carcinomas. Thus, oncologists and cooperative groups should rely on their local pathologists' diagnoses for the major choices of therapies in lung cancer and realize that there remain a small number of overlapping tumors that are not uniformly diagnosed by routine light microscopy and that require more sophisticated techniques if their diagnosis is to be accurate.

Carcinoma, Small Cell↗

Pathologist's role in product-related deaths.

The forensic pathologist can provide invaluable aid in all product liability death cases, regardless of the theory of recovery being used. Depending on the circumstances of the individual case, an attorney may emphasize the role of the pathologist as the initial investigator of the cause of death for the local government, as private consultant in the preparation and development of the case, or as expert witness on the issues of defect and causation.

Accidents, Home↗

Decision making by pathologists. A strategy for curtailing the number of inappropriate tests.

Studies indicate that many laboratory tests are performed unnecessarily. We devised a strategy that proved very effective in curtailing unnecessary performance of immunoelectrophoretic analyses, based on the assumption of a decision-making role by the pathologist in rejecting a request for immunoelectrophoresis when serum protein electrophoresis and quantitative immunoglobulin levels are normal. The adoption of this policy resulted in a 67% reduction in the number of immunoelectrophoretic analyses performed in our laboratory. Thus, the assumption of a decision-making role by pathologists can be extremely effective in decreasing the number of inappropriate laboratory tests.

Cost Control↗

Legal competency of aphasic patients: role of speech-language pathologists.

Aphasia is a disorder that is not generally known to the nonmedical profession. It is therefore difficult for attorneys unfamiliar with aphasic deficits to comprehend the full extent of the problem. Too often the speech-language pathologist's knowledge of the patient's communication abilities is not utilized by the legal community. This clinical note stresses the need for the speech-language pathologist's input in legal proceedings concerning aphasic patients.

Aphasia↗

The pathologist's role in management of patients with Hodgkin's disease.

The pathologist's role in the management of patients with Hodgkin's disease may be summarized as follows: (a) to establish a firm diagnosis of Hodgkin's disease: (b) to recognize the value of the Lukes-Butler classification in histologic diagnosis as well as its limitations as a prognostic indicator in patients undergoing modern therapy; (c) to carefully examine and identify all sites of involvement in staging laparotomy material; and (d) to prepare tissues for appropriate histopathologic studies and for new techniques in the investigation of Hodgkin's disease. The pathologist should demand of his or her technician optimal histopathologic sections since technical artifacts frequently compound diagnostic problems. Poor-quality sections clearly constitute one of the major obstacles to the diagnosis and subclassification of Hodgkin's disease and allied disorders.

Diagnosis, Differential↗

College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Report of the Colorectal Cancer Working Group.

The College of American Pathologists Conference XXVI in June 1994 was devoted to a discussion of the clinical relevance of prognostic factors in three solid tumors (breast, prostate, and colorectal). The group considering prognostic factors for adenocarcinoma of the large gut consisted of 15 pathologists, investigators, and surgeons. The group concluded that only a few items are well supported in the existing literature and can be recommended for routine clinical use at this time (pathologic TNM information and stage, tumor type, tumor grade, extramural venous invasion, and preoperative serum carcinoembryonic antigen level). According to the classification system used at the conference, these markers warrant categorization as important prognostic factors (category I). A few factors should be considered as potentially useful after further study (category II). Furthermore, the group agreed that all other current measurements of so-called prognostic factors do not warrant the same recognition of importance, either because they have been studied insufficiently or studies have demonstrated that they do not contribute to prognostication. These additional items were placed in category III. It was also concluded that the statistical methods used to identify and validate prognostic markers, as well as their integration into single statements of prognosis need further national evaluation and standardization.

Biomarkers, Tumor↗

The pathologist's role in the diagnosis and therapy of rectal cancer.

The pathologist's role in the diagnosis and therapy of rectal cancer is reviewed. Basically, it concerns the diagnosis established at biopsy, the staging and the definition of prognostic factors. The biopsy-proven diagnosis confirms the clinical or radiologic diagnosis of malignancy while the histological type and grading is also assessed. The latter includes three levels and is based on the tubular clumping of neoplastic cells. The most commonly used staging systems: Dukes' classification, TNM, and Jass' system are presented. The staging aspects which impact on prognosis are stressed. Particular attention is paid to the specific problems of preoperative radiochemotherapy which frequently affects the initial grading and staging. Finally, the role the pathologist plays in the definition of histopathologic prognostic factors complementary to the conventional morphological study, is underlined.

Biopsy↗

The pathologist and managed care. Integration into the new health care delivery system.

As the health care system evolves, managed care plans are expanding rapidly, and pathologists face radical changes in contractual relationships and payment methodology. As a result, entirely new relationships will often need to be negotiated to adapt successfully. The experience of pathologists in areas where there is already high market penetration by managed care plans can be used in strategic planning, learning to gain entry to negotiations, and planning what and how to negotiate. Proper preparation is critical to successful negotiations in our new health care system and requires an understanding of capitation, contracting risks, and opportunities.

Capitation Fee↗

The stability of survey-assigned assay values when surveyed control materials are used in a daily interlaboratory quality control program. The College of American Pathologists Chemistry Survey--Quality Assurance Service shared pool experience.

Two pools of lyophilized human control serum, distributed as challenges for the 1990 and 1991 College of American Pathologists Comprehensive Chemistry Surveys were employed consecutively as two-level, daily, quality control materials in College of American Pathologists Quality Assurance Service Regional Quality Control programs. Because the Chemistry Survey and Quality Assurance Service use identical method codes and the materials are essentially stable, the variation of differences among Chemistry Survey and Regional Quality Control assay values is a sensitive measure of both the variation of accuracy among calibrator-assigned values and of the matrix response among calibrator/reagent lots following the time of initial Chemistry Survey assay. In the two cycles of data comparison, the Regional Quality Control means for the assay values of 15 stable routine chemistry analytes showed no statistically significant differences from the initial Chemistry Survey for 295 of 361 analyte-method combinations studied 16 months later. Statistically significant changes between Chemistry Survey assay values and Regional Quality Control means most often occurred with closed rather than with open analytic systems and were predominantly in the same direction at both concentration levels. The magnitude of bias difference was usually less than the average within-laboratory standard deviation for the same analyte concentration. Of 64 analyte-pool combinations studied, a single instance of probable analyte instability was noted, ie, decreasing level I glucose during the first cycle. Our findings strongly support the usefulness of Chemistry Survey-assigned target values to help strengthen the intralaboratory accuracy base. They also point out the need for and the utility of Regional Quality Control-recalculated interlaboratory means to supplement assay values assigned at the time a control pool was put into use.

Chemistry, Clinical↗

Surgical pathology sign-out. Routine review of every case by a second pathologist.

This article describes a 1-year study undertaken to evaluate the cost and effectiveness of a surgical pathology quality assurance system in which a second pathologist routinely reviews (before release of the report) all surgical pathology cases requiring microscopic sections. The study included 5,397 cases. Fourteen discrepancies of potential clinical significance were detected by the second observer, for an error rate of 0.26%. Consultation with the clinical physicians involved in these cases indicated that in seven of these cases, the error would have resulted in a different clinical intervention than actually occurred. This "checker" sign-out system added an estimated $7 to the cost of each case, or $2,700 for each discrepancy of potential clinical significance. The value of the dual pathologist sign-out system as described here requires confirmation, because there is a paucity of information in the literature relating to routine surgical pathology sign-out accuracy.

California↗

Body fluid microscopy in US laboratories. Data from two College of American Pathologists surveys, with practice recommendations.

Questionnaires addressing laboratory practices in cerebrospinal fluid and body fluid (serous, synovial) microscopy were distributed to participants in the Clinical Microscopy Survey of the College of American Pathologists, Northfield, Ill, in 1985 and 1989. In both Surveys, cell enumeration was performed primarily by hemocytometry, while nearly all respondents used Wright-stained microscopy. There was little formal quality control to assess the accuracy of counts or differential cell count. Less than 55% of laboratories used the cytocentrifuge. About half of respondents performed a differential cell count on every sample. Slides with atypical or malignant cells were usually (> 85%) reviewed by physicians without automatic referral to the cytopathology section. Only about half of respondents examined every synovial fluid specimen with polarized microscopy for crystals. Other than a modest increase in use of the cytocentrifuge, the 1989 Survey showed little interval change in practices. In 1989, there was equal dependence on Wright's and Papanicolaou's stains for an infrequent diagnosis of malignancy. The low rate of positives may have related to the high prevalence of wedge smears, a suboptimal technique. The Hematology and Clinical Microscopy Resource Committee of the College of American Pathologists makes recommendations for optimal laboratory handling of body fluid specimens for microscopy.

Body Fluids↗

Interpreting the pathologist's report.

It is imperative that the clinician/practitioner and diagnostic pathologist communicate. Both individuals practice their profession with innate professional biases based on training and experience. Like clinical medicine, pathology is a professional art and is subject to interpretative variance. When the clinician receives a pathological report that does not agree with the clinical presentation, there is an obligation to communicate the concern to the pathologist and request a second opinion or agree on the need for submission of additional biopsy material.

Data Interpretation, Statistical↗

Expert systems as an aid for the pathologist's role of clinical consultant: CANCER-STAGE.

The traditional role of the pathologist as a clinical consultant for various clinical specialists has become more difficult with the explosion of information that has taken place in the past decades. Rule-based expert systems offer the ability to store and quickly and efficiently retrieve information that is relevant to specific clinical situations. They are ideally suited for simple repetitive tasks such as the staging of patients with cancer and the retrieval of therapeutic and prognostic information. A microcomputer-based expert system, CANCER-STAGE, is described that allows a pathologist to perform these tasks with minimal computer training. The system was constructed by utilizing an inexpensive expert system development package (EXSYS). The knowledge base from the literature is stored in 370 IF-THEN rules that have notes with therapeutic information and references. The computer user interacting with the system answers questions and is quickly provided with the TNM stage of a particular patient and a short summary with therapeutic options. The conditions can be changed and the results of various WHAT-IF simulations compared for educational purposes.

Consultants↗