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At least 415 records · Page 23Linked to original sources
PubMed1984

Effect of 1-p-bromotetramisole on mineralization of hamster tooth germs in vitro: a light and electron microscopic study.

In culture, 10(-3)M 1-p-bromotetramisole (1-pBTM) inhibited mineralization of in vitro secreted enamel matrix in two-day old neonatal hamster first maxillary molar tooth germs. In contrast, in control tooth germs cultured without the inhibitor, new enamel and dentin matrices were secreted and subsequently mineralized in vitro. It is suggested that the arrested enamel matrix mineralization in vitro is a result of reduced phosphate uptake due to alkaline phosphatase inhibition by 1-pBTM. In addition, 1-pBTM induced accumulation of secretory granules in odontoblasts and ameloblasts, but not in the other cells. This is probably a specific effect of the inhibitor on these cells due to alkaline phosphatase inhibition.

Alkaline Phosphatase↗
PubMed1983

A histological study of the innervation of developing mouse teeth.

The innervation of developing mouse teeth between initial formation and crown formation was investigated using silver-stained serial sections. The developing innervation correlated with the stage of development of individual teeth rather than the chronological age of the mice. Nerves approached the developing dental papilla during the bud stage and formed a basal plexus below the dental papilla in the early cap stage. Nerve fibres from this plexus spread into the dental follicle as it began to develop. However, nerves did not enter the dental papilla until crown formation commenced, when the innervation was fairly rapid. Innervation commenced in the incisor teeth as soon as dentinogenesis started but not until a thin layer of enamel had been formed in the molar teeth. Although some of the early fibres were associated with blood vessels, many nerves lay free in the pulp. The absence of nerves in intimate relationship to the presumptive dental regions during the inductive phase of tooth development suggests that neural induction plays no part in the initiation of odontogenesis. However, it is not possible, from a purely histological study such as this, to attribute any function to the nerves at other stages of tooth development until the neurotransmitter content, and hence the type and likely function of the nerves, is established.

Amelogenesis↗
PubMed1982

Progressive mineralization pattern of developing enamel during the maturation stage.

The maturation stage of developing enamel may be divided into three substages: First, a secondary mineralization increase appears from the surface toward the deeper layer; then, a tertiary mineralization increase takes place from the deeper layer toward the surface; and finally, the narrow subsurface layer mineralizes heavily and attains the highest degree of mineralization of all layers.

Animals↗
PubMed1982

Organ culture of tooth germs: relationship between alkaline phosphatase and mineralization in vitro.

In the 3rd day 2nd molar of the hamster, mineralization of the tooth germ has been studied in vitro starting from unmineralized predentine stage up to secretory amelogenesis. The explants were cultured in BGJb medium containing 15% foetal calf serum. The biochemical data on whole tooth germs were compared morphometrically with its main calcifying components. The alkaline phosphatase seems not to be related to cell-division but more to mineralization. There the alkaline phosphatase appeared to be more correlated with the phosphorus than with the calcium uptake. Its function in mineralization of the tooth germ seems also to be more expressed in dentinogenesis than in amelogenesis.

Alkaline Phosphatase↗