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At least 433 records · Page 24Linked to original sources

PubMed2005

Bioaerosol emission rate and plume characteristics during land application of liquid class B biosolids.

This study investigated bioaerosol emission rates and plume characteristics of bioaerosols generated during land application of liquid Class B biosolids. In addition, it compared the rate of aerosolization of coliphages and total coliform bacteria during land application of liquid Class B biosolids to the rate of aerosolization during land application of groundwater inoculated with similar concentrations of Escherichia coli and coliphage MS2. Air samples were taken immediately downwind of a spray applicator as it applied liquid (approximately 8% solids) biosolids to farmland near Tucson, Arizona. Air samples were also collected immediately downwind of groundwater seeded with MS2 and E. coli applied to land in an identical manner. Air samples, collected with liquid impingers, were taken in horizontal and vertical alignment with respect to the passing spray applicator. Vertical and horizontal sample arrays made it possible to calculate the flux of microorganisms through a virtual plane of air samplers, located 2 m downwind of the passing spray applicator. Neither coliphages nor coliform bacteria were detected in air downwind of spray application of liquid Class B biosolids. Based on limits of detection for the methodology, the rate of aerosolization during land application of liquid biosolids was calculated to be less than 33 plaque forming units (PFU) of coliphage and 10 colony forming units (CFU) of coliform bacteria per meter traveled by the spray applicator. The rate of aerosolization during land application of seeded groundwater was found to be, on average, 2.02 x 10(3) CFU E. coli and 3.86 x 10(3) PFU MS2 aerosolized per meter traveled by the spray applicator. This is greater aerosolization than was observed during land application of biosolids. Because concentrations of coliphages and coliforms were similar in the liquid biosolids and the seeded water, itwas concluded that some property of biosolids reduces aerosolization of microorganisms relative to groundwater. Additional experiments utilizing a novel air sampling protocol showed that the duration of bioaerosol exposure immediately (2 m) downwind of biosolids spray application is brief and the plume of bioaerosols generated is discrete. Additional air samples showed that aerosolization of coliphages and coliform bacteria after liquid biosolids have been applied to land does not occur at detectable levels.

Aerosols↗

PubMedDate not supplied

The size and distance of the opposite flat applicator change the SAR and thermal distributions of RF capacitive intracavitary hyperthermia.

The variations of the specific absorption rate (SAR) and thermal distributions in the JSHO QA phantom were investigated by using the radiofrequency (RF) capacitive intracavitary hyperthermia (ICHT) applicator (AP-T01, Omron Electric Co., Kyoto, Japan) and the opposite flat applicators of different sizes (AP-75E: 7.5 cm in diameter, AP-100E: 10 cm in diameter, and AP-150E: 15 cm in diameter). The influences of the distance between both applicators were also investigated. Heating of the region between both applicators became weaker with the increase in size of the opposite flat applicator, and it became stronger with the decrease of the distance between both applicators. Heating near the flat applicator became weaker with the increase in size of the flat applicators, and it showed no apparent difference with the increase of the distance between both applicators. The normalized SAR values between AP-T01 and the opposite flat applicator became smaller and its slope became steeper with the increase in size of the opposite flat applicator and in the distance between both applicators. These results suggest that the variability of the specific absorption rate (SAR) and thermal distributions of the region between both applicators may show the potentiality of usefulness for heating the tumours of various sizes, shapes and location.

Humans↗

PubMed1997

The effect of a rolling admission policy on a medical school's selection of applicants.

PURPOSE: As the University of Kentucky College of Medicine (UKCM) employs a rolling admission policy, this study was designed to determine (1) whether the month during which applicants were considered by the UKCM admission committee was associated with admission status, (2) whether applicants considered early in the process differed in selected academic and noncognitive pre-admission characteristics in comparison with later applicants, and (3) what the importance of the month of the applicant's consideration was relative to other predictors of admission to UKCM. METHOD: The application files and admission committee's minutes regarding 302 applicants who received interviews during the 1993-94 application cycle were examined. Data reviewed included each applicant's gender, age, geographic origin, undergraduate science and non-science grade-point averages, and Medical College Admission Test scores; the date of consideration by the committee; interviewers' ratings; the initial motion on the applicant; and the final admission status. RESULTS: The findings indicate that the applicants considered earlier were significantly more likely to gain admission. However, upon assigning the applicants to three groups according to the month of consideration, no difference in academic qualifications was found. Regression analyses revealed that despite the effect of time of consideration, noncognitive characteristics related to UKCM's mission also predicted admission decisions. CONCLUSION: This study provides useful information to admission committees reviewing the effect of a rolling admission policy, as well as to applicants and premedical advisors, who should be aware of the potential importance of submitting applications in a timely manner.

Adult↗

PubMed2001

Longitudinal trends in the applicant pool for U.S. medical schools, 1974--1999.

PURPOSE: To examine the pool of applicants to U.S. medical schools from 1974--1999 for changes in size and demographics and to identify factors that may be associated with such changes. METHOD: Data on characteristics of the total applicant pools to U.S. medical schools for 1974--1999 were collected from the Association of American Medical Colleges' Data Warehouse. Data on undergraduates' receiving bachelor's degrees and unemployment rates were obtained from the National Center for Education Statistics and the U.S. Bureau of Labor Statistics, respectively. Variables such as race/ethnicity, gender, age, and first time or reapplicant status were compared across the study period. RESULTS: The percentage of women applicants increased from 20% of the pool in 1974 to 45% of the pool in 1999, while the percentage of men dropped from 80% to 55%. The number of underrepresented minority (URM) applicants increased 45% during the period, from 2,890 to 4,181, but URM applicants represented only 11% of the total applicant pool in 1999. Between 1974 and 1999, the number of URM men applying to medical school dropped by 18%, from 1,984 to 1,629, while the number of URM women nearly tripled, from 906 to 2,552. The number of Asian/Pacific Islander applicants increased dramatically, from 986 in 1974 to 7,622 in 1999, and they now represent a fifth of all applicants. The proportion of reapplicants grew when the applicant pool grew and it shrank when the applicant pool shrank. No relationship was found between the size of the applicant pool and economic indicators, age, or geographic origin. CONCLUSION: Changes in the proportions of women and Asian/Pacific Islander applicants were the driving force in the expansion of the applicant pool between 1974 and 1999.

Adult↗

PubMed2005

Effect of topical corticosteroid application frequency on histamine-induced wheals.

BACKGROUND: Very few studies have been conducted to assess the effect of corticosteroid application frequency to attain maximum benefit with minimum side-effects. OBJECTIVES: Compare the efficacy of twice-daily, once-daily and alternate-day applications of clobetasol propionate (0.05%) and compare whether an initial once-daily application followed by a subsequent alternate-day application is as effective as a once-daily application. METHODS: The ability of corticosteroids to suppress histamine-induced wheals on human skin was used as a human bioassay model. Of the 26 subjects included, 21 completed the 1st phase. In the 2nd phase, 11 subjects were included and all completed the study. Four sites were chosen on the left forearm. Clobetasol propionate (0.05%) was applied twice daily, once daily, and on alternate days, and on the control site a color, texture and odour-matched vehicle was applied. Prick test with histamine was carried out after 10 days. In the 2nd phase, clobetasol propionate (0.05%) was applied once daily for 14 days and compared with the initial once daily for 7 days and the subsequent alternate-day application for 7 days. Prick test was carried out after 14 days. RESULTS: The once-daily application of clobetasol propionate (0.05%) was as effective as the twice-daily application, but the alternate-day application was less effective than the once-daily application (P < 0.01). Also, the initial-daily and subsequent alternate-day applications were not as effective as the continuous once-daily application (P < 0.05). CONCLUSION: A once-daily application of clobetasol propionate (0.05%) is likely to provide the required therapeutic effect.

Administration, Cutaneous↗

PubMed1998

Misrepresentation of publications by applicants for radiology fellowships: is it a problem?

OBJECTIVE: We performed this study to determine whether applicants to the body and breast/body imaging fellowship programs at our institution misrepresented their publications in their applications or curricula vitae, as has been reported recently regarding applicants for gastroenterology fellowships. We also wanted to alert program directors to this issue. MATERIALS AND METHODS: For each applicant in 1992-1995, every article cited on an application form or curriculum vitae as published or in press was cross-referenced with computer databases or the actual journals. RESULTS: Of 201 applicants, 87 (43%) listed at least one article citation (total citations, 261; mean number of citations, 3.0; maximum number of citations, 20). Of 261 citations, 39 (15%) could not be verified. Seven articles (listed by six applicants) did not appear in print 16-30 months after being listed as in press; six citations (by six applicants) put the applicant's name higher on the authorship list than was actually true; two articles (by two applicants) were not in the location cited or elsewhere; and 24 articles (by 14 applicants) were listed as appearing in journals that could not be found. The first three categories were judged as misrepresentations of publications; the fourth category was judged indeterminate for misrepresentation. CONCLUSION: A minimum of 16% (14/87) of applicants to the body and breast/body imaging fellowship programs at our institution who cited publications, or 7% of all 201 applicants in the time studied, appear to have misrepresented their publication record. Program directors should be aware of the possible means for prevention of this problem.

Fellowships and Scholarships↗

PubMedDate not supplied

Do general surgery applicants really want to be general surgeons?

OBJECTIVE: The authors sought to compare categorical general surgery applicants with applicants in other specialties regarding their final specialty-choice ranking for residency positions. METHOD: The authors analyzed the 2004-match year applicant-pool data from the Electronic Residency Application Service and Common Application Service as well as rank-list data from the National Resident Matching Program (NRMP), the Urology Match Program, and the San Francisco Matching Program for 20 different specialties. Two-tailed chi-square tests measured differences between the proportions of applicants who ultimately ranked programs in categorical general surgery and each of 19 other specialties and between the proportions of U.S. students who ranked categorical general surgery and each of 19 other specialties as a non-preferred choice. A Bonferroni-adjusted alpha was set at 0.0013 to reduce the likelihood of a type I error. RESULTS: The proportion of applicants ranking each specialty ranged from 42% (786/1859) in pathology to 91% (282/31l) in neurological surgery. The proportion of categorical general surgery applicants ranking categorical general surgery programs was 51% (2004/3900), which was significantly lower than the proportions ranking 12 of 19 other specialties (each p < 0.001). Of the 2004 categorical general surgery applicants ranking categorical general surgery programs, 278 (278/2004, 14%) ranked categorical general surgery as a non-preferred specialty. Among 1230 U.S. students ranking categorical general surgery programs, 144 (12%) did so as a non-preferred specialty-a proportion significantly higher compared with U.S. students ranking 15 of 19 other specialties as non-preferred (each p < 0.001). CONCLUSIONS: In 2004, the categorical general surgery applicant pool was relatively uncommitted to the specialty of general surgery. The number of applicants ranking categorical general surgery as a non-preferred specialty was likely even higher than these data indicate, as unmatched applicants in non-NRMP matches who then ranked categorical general surgery programs in the NRMP were tabulated by the NRMP as having ranked categorical general surgery as their preferred specialty.

Career Choice↗

PubMed2003

An audit of job application forms in response to adverts in the British Medical Journal.

OBJECTIVE: The aim of this study was to examine the speed of response of human resources departments to requests for job application forms for posts advertised in the British Medical Journal (BMJ). Of particular interest was the closing date for applications, postage cost, and the period to reply. DESIGN: Twenty posts were randomly selected and application forms requested by telephone and then 20 by letter on two separate dates from the BMJ Classified (issues of 21 July 2001 and 28 July 2001). During the first week the forms were requested by telephone on receipt of the BMJ (Friday afternoon). During the second week the forms were requested by first class post. All letters were sent out on Saturday morning. OUTCOME MEASURES: The date of receipt of the application form/information pack, the cost of postage, and the closing date for application were recorded for each position. RESULTS: Fifteen forms were received after the telephone application and 18 forms after the letter applications. One trust sent two replies spaced one week apart for the same job and two replies contained job application forms for the wrong job. The response rates to telephone requests varied from four to 10 days and by letter from three to 12 days. The minimum time between the reply being received and the closing date was one day, and the maximum 21 days. The time between the closing date for applications and the start date of the job varied from minus one week (closing date before advertisement) to three months. Thirteen replies gave no indication of the start date of the job. The cost of postage varied from 27p to pound 1.90. Thirty one trusts used first class postage. CONCLUSION: There is very limited scope to return job application forms on time, and significant delays in sending out application forms and information packs compound this problem. It is recommended that trust human resources departments place advertisements early and respond promptly to requests for application forms.

Advertising↗

PubMed2003

Misrepresentation of research publications among orthopedic surgery fellowship applicants: a comparison with documented misrepresentations in other fields.

Study Design. A retrospective study was used to review fellowship applications over 3 years. Objectives. To assess the prevalence of research misrepresentation in orthopedic fellowship applications, and to compare such activity between subspecialties (e.g. spine, sports, hand). Summary of Background Data. Competition for orthopedic surgery fellowships is intense. The applicant pool includes orthopedic, plastic, and general surgeons, as well as neurosurgeons. Residency and fellowship training programs in other disciplines have documented shocking levels of misrepresentation in the curriculum vitae of prospective applicants. However, no study has looked at orthopedic residents applying for subspecialty fellowship programs. Methods. A retrospective analysis investigated 280 applications for fellowship positions in the department of orthopedic surgery at the authors' academic institution from 1996 to 1998 inclusively. To allow for press and publication delays, a minimum 24-month follow-up period was instituted. The listings of applicants' research publications were analyzed for evidence of misrepresentation through an exhaustive literature search. Only the most obvious confirmable discrepancies were labeled as misrepresentations. The results then were compared with those found in studies conducted in other fields: gastroenterology fellowship, emergency medicine residency, pediatric residency, dermatology residency, orthopedic residency, and medical faculty applications. Results. Among 280 (54%) applicants for orthopedic surgery candidates, 151 claimed journal publications. It was found that 16 (10.6%) of these 151 applicants had misrepresented their citations. This rate was highest in spine fellowship applicants (20%). However, considering the numbers available, this was not significantly different among the various subspecialty fellowship applicants (P>0.1). In addition, various demographic data did not correlate with the rate of misrepresentation (P>0.1). These results are comparable with those reported in other medical fields (P>0.1). Conclusions. Misrepresentation occurs in orthopedic fellowship applications at a rate comparable with that observed in other fields. This rate is not different among the various subspecialties in orthopedics. Policies that may lessen the incidence of falsification on curriculum vitae should be instituted in an attempt to curb such activity.

Fellowships and Scholarships↗

PubMed2004

Otolaryngology-head and neck surgery residency match: applicant survey.

OBJECTIVE: To examine satisfaction with the match process and reported failures to comply with the match rules among applicants of the January 2002 Otolaryngology-Head and Neck Surgery match. DESIGN: A survey was mailed to all applicants completing the 2002 San Francisco Matching Program match. PARTICIPANTS: Surveys were mailed to 312 applicants, and the 151 returned surveys were entered into a database, which was then subjected to statistical analysis. MAIN OUTCOME MEASURES: Survey questions asked whether the applicant matched and how highly, how well the applicant considers the match to fulfill its goals, how many interviews the applicant attended, and how many of these included perceived noncompliance with San Francisco Matching Program rules by region of the country. RESULTS: Satisfaction with the match correlated significantly (P<.001) to how highly the applicant matched among those successfully matching. The satisfaction among matching applicants was significantly better (P<.001) than those not matching. The 151 respondents had a total of 970 interviews. The respondents reported that they identified noncompliance with the match rules in 42 (4.3%) of these encounters. Most (87%) respondents reported full adherence to the match rules, and the degree of adherence did not correlate significantly to applicants' satisfaction (P =.71). CONCLUSIONS: Applicants' satisfaction with the match process depended significantly on their match outcome. Rule noncompliance was rare and not significantly related to applicant satisfaction. This study suggests that otolaryngology applicants perceive high levels of satisfaction with the match and infrequent breaches of stated match rules.

Attitude↗

PubMed1997

Influence of brachytherapy applicators geometry on dose distribution in cervical cancer.

AIM: Although the relationship between the dose delivered to adjacent organs (urinary bladder and rectum) and the frequency and severity of treatment complications has been reported in many series, the factors influencing pelvic dose distribution are not well defined. The aim of the study was to assess retrospectively the influence of the size of cervical cancer brachytherapy applicators (ovoids and uterine tandems) on pelvic dose distribution and the impact of various therapy-dependent factors on patient anatomy and on dose distribution in particular applications. PATIENTS AND METHOD: The subject of this study were 356 cervical cancer patients treated with Selectron LDR as a part of their radical radiotherapy. Analysed factors included preceding external beam radiotherapy (EBRT) or brachytherapy applications, use of general anaesthesia for application and the system of pellet loading. RESULTS: Significant correlation was found between the size of applicators and doses to bladder, rectum and points B: larger vaginal applicators produced lower dose in bladder and rectum and higher dose in point B (all p < 0.0001), longer uterine tandems produced lower dose in rectum and higher dose in point B (both p < 0.0001). Significant decrease in the frequency of use of large applicators (ovoids: p < 0.0001, tandems: p = 0.055) and worsening of dose distribution, i.e. higher doses to critical organs (respectively: bladder p = 0.0012, rectum p = 0.02) and lower point B dose (p = 0.0001) were observed at consecutive brachytherapy applications. Similar situation occurred in patients, who received EBRT prior to brachytherapy (ovoids: p < 0.001, tandem: p = 0.04, bladder dose: p = 0.009, rectal dose: p = 0.073, point B dose: p = 0.059). Vaginal applicators were larger (p = 0.026) and the dose distribution was better (bladder: p = 0.023, rectum: p = 0.002, point B: p = 0.0001) in patients who had their insertions performed under general anaesthesia. The comparison of 2 consecutively used systems of pellet loading revealed more favourable dose distribution: lower dose for bladder (p = 0.014) and higher dose for point B (p < 0.0001) for the system, which utilised more sources in ovoids and in the distal part of the uterine tandem, in spite of more frequent use of smaller applicators in this group of patients. In multivariate analysis ovoid size was related to preceding external beam radiotherapy (p = 0.025). Uterine tandem length was dependent on the number of preceding intracavitary applications (p < 0.001) and preceding external beam radiotherapy (p = 0.007). Bladder dose was related to preceding brachytherapy (p = 0.011) and the pattern of pellet loading (p = 0.031). Rectal dose was dependent only on the use of general anaesthesia during application (p = 0.001) and point B dose was dependent on the pattern of pellet loading (p < 0.001) and marginally-on the use of preceding external beam radiotherapy (p = 0.06). CONCLUSIONS: The results of this study allow for identification of treatment-related factors determining pelvic dose distribution in cervical cancer brachytherapy and may potentially enable optimisation of this distribution in particular clinical situation.

Brachytherapy↗

PubMed2004

Costs of emission-reducing manure application.

Favourable economics of handling and application of manure are of fundamental importance to encourage the implementation of emission-reducing application techniques. The economics of manure application depend on the costs of the equipment and the time to carry out the field operation. In this study the costs of application techniques designed to reduce ammonia losses were assessed and compared with the costs of conventional broadcast spreading across a range of farm characteristics. A model was developed to calculate the costs and time requirements of manure application. Data on factors affecting the costs were used from different countries in Europe. The calculations showed that for a range of farm characteristics with a manure production of 1000-3000 m(3)y(-1), the costs of manure application by trailing hose, trailing foot, shallow injector and arable land injector were approximately 2 m(-3) higher than for broadcast spreading. The cost difference between broadcast spreading and the other application techniques decreased with farm size. The average additional costs of manure application by a trailing foot or a shallow injector decreased by 15% on small extensive farms to more than 50% on intensive farms, when the fertiliser value of the nitrogen was taken into account. The field application itself took less than 50% of the operating time in the process of the manure handling and application. With an increasing application rate, the relative contribution of the time for field application decreased.

Agriculture↗

PubMed2003

Applicants' opinions about the selection process for oral and maxillofacial surgery programs.

PURPOSE: This study was conducted to investigate the characteristics of and opinions about the selection process of applicants to residency programs in oral and maxillofacial surgery (OMS) in the year 2000. The current investigation paralleled a survey completed in the 1970s, with additional questions to assess contemporary curriculum and surgical training evolution. Differences from the previous (1976) survey, a profile of applicants in 2000, and characteristics of OMS residency programs that applicants view as attractive are discussed. SUBJECTS AND METHODS: Questionnaires were sent to 307 applicants to OMS residency programs registered in the dental matching program. To provide a more direct comparison of the study completed in 1977, the current questionnaire used the original survey as a model. It was divided into 6 sections: general information, information from the formal application and letters of recommendation, the interview, the selection process, the characteristics applicants were seeking in a program, and a retrospective review of programs visited. RESULTS: In this study, 118 responses were received, representing 38% of the total. Respondents were predominately men (86%) and single, and attended dental school in all regions of the United States and the world. Respondents listed geographic location (65%) and national reputation (58%) as important factors for selecting programs to which to apply. Many respondents felt that a previous dental internship (85%), national board scores (83%), and class rank (79%) would be considered important in screening applicants for interview. A program's reputation, personalities of residents and attending staff, and clinical material were ranked as important factors contributing to program selection. Fifty-three of the 79 successful applicants reported that they were matched with their first-choice institution. Sixty percent of programs were considered worthy of revisiting by the respondents. CONCLUSIONS: Respondents in 2000 had more knowledge of the selection process before interviewing and submitted 2 times the number of applications than applicants in 1977. When selecting programs to which to apply, current applicants were less influenced by geographic location and the recommendations of other dentists. Applicants were attracted to programs that they perceive to have a good reputation and abundant clinical material. Residencies that convey a friendly atmosphere, favorable interpersonal skills of enrolled residents, and appealing personalities of the faculty were more attractive to candidates.

Adult↗

PubMedDate not supplied

Combination of transurethral and interstitial ultrasound applicators for high-temperature prostate thermal therapy.

The purpose of this study was to determine the feasibility of using a transurethral ultrasound applicator in combination with implantable ultrasound applicators for inducing thermal coagulation and necrosis of localized cancer lesions or benign disease within the prostate gland. The potential to treat target zones in the anterior and lateral portions of the prostate with the angularly directive transurethral applicator, while simultaneously treating regions of extracapsular extension and zones in the posterior prostate with the directive implantable applicators in combination with a rectal cooling bolus, is evaluated. Biothermal computer simulations, acoustic characterizations, and in vivo thermal dosimetry experiments with canine prostates were used to evaluate the performance of each applicator type and combinations thereof. Simulations have demonstrated that transurethral applicators with 180-270 degrees acoustic active zones can direct therapeutic heating patterns to the anterior and lateral prostate, implantable needles can isolate heating to the posterior gland while avoiding rectal tissue, and that the combination of applicators can be used to produce conformal heating to the whole gland. Single implantable applicators (1.8 mm OD x 10 mm long, approximately 180 degrees active sector, approximately 7 MHz, direct-coupled type) produced directional thermal lesions within in vivo prostate, with temperatures >50 degrees C extending more than 10 mm radially after 10-15 min. Combination of interstitial applicators (1-2) and a transurethral applicator (3-2.5 mm OD x 6 mm long, approximately 180 degrees active sector, 6.8 MHz, 6 mm OD delivery catheter) produced conforming temperature distributions (48-85 degrees C) and zones of acute thermal damage within 15 min. The preliminary results of this investigation demonstrate that implantable directional ultrasound applicators, in combination with a transurethral ultrasound applicator, have the potential to provide thermal coagulation and necrosis of small or large regions within the prostate gland, while sparing thermally sensitive rectal tissue.

Acoustics↗

PubMed1997

Design of applicators for a 27 MHz multielectrode current source interstitial hyperthermia system; impedance matching and effective power.

In interstitial heating one of the main requirements for achieving a certain elevated temperature in a tumour is that the effective power per applicator (Peff), i.e. the power which is actually deposited in the tissue, is sufficiently high. In this paper this requirement is discussed for the applicators of the 27 MHz multielectrode current source (MECS) interstitial hyperthermia (IHT) system. To minimize power reflection, the applicator impedance was matched with the generator impedance by adjusting the length of the coaxial cable in between. Transmission line losses, applicator efficiency and subsequently Peff were computed for several applicator types. The actual Peff per electrode was obtained from calorimetric measurements. Experiments with RC loads, which can be seen as perfect applicators, were performed to investigate the effect of mismatching on Peff. Applicator losses were measured for clinically used applicators, both single- and dual-electrode, utilizing saline phantoms. A simple spherical tumour model, using the effective heat conductivity (keff) to account for heat transport, was used to estimate Peff for a given tumour size, implant size and applicator density. Computations of Peff of various MECS-IHT electrodes were in close agreement with the phantom measurements. Most of the initial generator power was absorbed in the transmission line (60-65%). The efficiency of the applicators was about 65%. For both single- and dual-electrode applicators the effective electrode power was found to be about 1 W. Model calculations show that Peff of 1 W is sufficient to reach a minimum tumour temperature of 43 degrees C in well perfused tumours (keff = 3 W m-1 degree C-1), using a typical implant with 2 cm electrodes and 1.5 cm spacing. Mismatching can considerably affect Peff. Both a reduction to almost zero and a two-fold increase are possible. However, because the matching theory is well understood, mismatching is not a serious problem in clinical practice and can even be used to increase Peff if necessary. We conclude that the applicator design and the impedance matching method chosen in the MECS system allow heating to temperatures in the therapeutic range with implants used in clinical practice.

Biophysical Phenomena↗

PubMed1992

Academic achievement and acceptance rates of underrepresented-minority applicants to medical school.

While the participation of minority groups underrepresented in medicine has increased from 3% of first-year enrollment in 1968-69 to 11% in 1992, many have been concerned that the percentage of underrepresented-minority applicants accepted is smaller than that of other applicants. To investigate the relationship of acceptance rates and measures of academic achievement, historical data from 1978-79 through 1991-92 on applicant characteristics maintained by the Association of American Medical Colleges were used to develop statistics on acceptance rates for underrepresented minorities and for other applicants, by each applicant's mean score on the MCAT (Medical College Admission Test) and undergraduate science grade point average. Those statistics were then related to trends in applicant numbers. Results show that acceptance rates for both underrepresented minorities and others increased as the numbers of applications from both groups declined, then decreased as applications again rose. When underrepresented-minority applicants were compared with other applicants within the same ranges of grades and MCAT scores, underrepresented-minority applicants were accepted at substantially higher rates in every stratum. Thus, medical schools generally are acting affirmatively in selecting applicants from underrepresented-minority groups.

Achievement↗

PubMed2003

Misrepresentation of research publications among orthopedic surgery fellowship applicants: a comparison with documented misrepresentations in other fields.

STUDY DESIGN: A retrospective study was used to review fellowship applications over 3 years. OBJECTIVES: To assess the prevalence of research misrepresentation in orthopedic fellowship applications, and to compare such activity between subspecialties (e.g., spine, sports, hand). SUMMARY OF BACKGROUND DATA: Competition for orthopedic surgery fellowships is intense. The applicant pool includes orthopedic, plastic, and general surgeons, as well as neurosurgeons. Residency and fellowship training programs in other disciplines have documented shocking levels of misrepresentation in the curriculum vitae of prospective applicants. However, no study has looked at orthopedic residents applying for subspecialty fellowship programs. METHODS: A retrospective analysis investigated 280 applications for fellowship positions in the department of orthopedic surgery at the authors' academic institution from 1996 to 1998 inclusively. To allow for press and publication delays, a minimum 24-month follow-up period was instituted. The listings of applicants' research publications were analyzed for evidence of misrepresentation through an exhaustive literature search. Only the most obvious confirmable discrepancies were labeled as misrepresentations. The results then were compared with those found in studies conducted in other fields: gastroenterology fellowship, emergency medicine residency, pediatric residency, dermatology residency, orthopedic residency, and medical faculty applications. RESULTS: Among 280 (54%) applicants for orthopedic surgery fellowships, 151 claimed journal publications. It was found that 16 (10.6%) of these 151 applicants had misrepresented their citations. This rate was highest in spine fellowship applicants (20%). However, considering the numbers available, this was not significantly different among the various subspecialty fellowship applicants (P > 0.1). In addition, various demographic data did not correlate with the rate of misrepresentation (P > 0.1). These results are comparable with those reported in other medical fields (P > 0.1). CONCLUSIONS: Misrepresentation occurs in orthopedic fellowship applications at a rate comparable with that observed in other fields. This rate is not different among the various subspecialties in orthopedics. Policies that may lessen the incidence of falsification on curriculum vitae should be instituted in an attempt to curb such activity.

Fellowships and Scholarships↗

PubMed2003

Effect of applicator diameter on lesion size from high temperature interstitial ultrasound thermal therapy.

High temperature ultrasound thermal therapy using interstitial and external approaches is becoming increasingly acceptable as a minimally invasive clinical treatment for cancerous and benign disease. The diameter of an interstitial applicator can influence its clinical practicality and effectiveness as well as application site. The purpose of this study was to determine whether the use of larger ultrasound transducers and the inherent increase in applicator size could be justified by potentially producing larger lesion diameters. Four applicator configurations and sizes were studied using ex vivo tissue experiments in liver and beef and using acoustic and biothermal simulations. Catheter-cooled and internally cooled applicators with outer diameters between 2.2 and 4.0 mm produced 3.5 to 5.0 cm diameter lesions in ex vivo liver and 3.0 to 3.5 cm lesions in ex vivo beef muscle with 20-40 W/cm applied for 10 min. Larger applicators produced lesions with radial penetration depths superior to their smaller counterparts at power levels in the 20-40 W/cm range. The higher cooling rates along the outer surface of the larger diameter applicators due to their greater surface area was a dominant factor in increasing lesion size. The higher cooling rates pushed the maximum temperature farther from the applicator surface and reduced the formation of high acoustic attenuation tissue zones. Applicator configuration and frequency (6.7-8.2 MHz) had less influence on lesion size than diameter in the ranges studied. Acoustic and biothermal simulations matched the experimental data well and were applied to model these applicators within sites of clinical interest such as prostate, uterine fibroid, brain, and normal liver. Lesions of 3.9 to 4.7 cm diameter were predicted for moderately perfused tissues such as prostate and fibroid and 2.8 to 3.2 cm for highly perfused tissues such as normal liver. In sites such as uterine fibroid where larger applicators placed using an endoscopic approach could be tolerated, treatment volume increases of 37% were predicted for an applicator diameter increase from 2.4 to 4.0 mm.

Animals↗