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Hanging wet-to-dry dressings out to dry.

Wet-to-dry dressings have been standard procedure for home care wound care patients although research indicates gauze dressings are not an optimal wound care modality for the patient, the clinician, or the healthcare system. Gauze dressings do not effectively support optimal healing and are more labor intensive to use than advanced dressings such as films, foams, hydrocolloids, and hydrogels. This article provides clinicians with the rationale and evidence needed to collaborate with physicians in choosing the most cost-effective wound care products to achieve positive patient outcomes.

Bandages↗

Crushing injury of the hand; prevention of ischemic contracture.

Crushing injury of the hand usually causes "explosive" damage. Subsequent swelling of the palmar structures further impairs venous outflow, and hemorrhage into structural spaces increases the pressure. The arterial system and the large dorsal veins, however, are seldom obstructed and provide adequate circulation unless hampered by improper bandaging. A bandage that compresses the dorsal veins causes back-pressure, which increases the swelling further and brings about ischemia. Swelling and pain cause the patient to restrict exercise of the injured hand, which permits contractures to develop. The author has averted this sequence in more than 100 cases by preserving integrity of veins during debridement, arresting hemorrhage, bandaging the hand with compression dressings in functional flexion, and reducing swelling with hyaluronidase. In these cases, on removal of bandages in 24 hours, swelling was reduced and continued to diminish. All patients exercised the hand at this time without discomfort and only a few required aspirin for pain.

Bandages↗

Rhinophyma: treatment with electrocautery and silver-impregnated porcine xenograft.

A typical case of advanced rhinophyma is reported. Partial excision reduced the size of the nose by two-thirds, leaving a thin layer of dermis. This was covered with silver-impregnated porcine xenograft, which allowed efficient drainage and remained adherent in its initial application for 2 weeks. A total of four applications of silver-impregnated porcine xenografts--the last two involving only very small areas--were required for complete epithelialization at 5 weeks after surgery. We believe that this xenograft is an ideal dressing for wounds resulting from partial excision of rhinophymatous tissue, providing the beneficial effects of biological dressings, including the hemostatic effects of collagen with the added benefit of silver's potent antibacterial properties. Silver-impregnated porcine xenograft reduces patient discomfort and results in rapid healing with excellent cosmetic results.

Aged↗

Evaluation of biological dressings.

The use of biological dressings in the treatment of burns is reviewed. Many theoretical advantages were initially proposed, but time and controlled studies have disproved some of them. Biological dressings are nevertheless helpful in relieving pain, protecting exposed vital structures, reducing exudative protein and erythrocyte loss and evaporative water loss, protecting granulation tissue, antibacterial activity, and testing a recipient bed's readiness for grafting. They probably offer no benefit in final wound debridement and primary dressings for partial thickness burns or split skin donor sites. There is no conclusive evidence that biological dressings alter epithelialization or the rate of formation of granulation tissue. A review of our last 100 cases at the Bothin Burn Center generally supports these conclusions with evidence of the superiority of homografts over heterografts.

Bandages↗

Burn wound management.

Management of a burn wound is interrelated with many patient care protocols. After the patient has received initial care, is in stable condition, and has been transported to the appropriate medical facility, the selection of burn wound treatment protocols is based on patient population. Hydrotherapy, debridement, topical antimicrobial agents, and dressings reduce bacterial colonization until the wound closes. Supportive care is essential to the preservation of viable tissue. Excision and autografting are the primary method of wound management. The practical application of cultured autograft and growth factors is under study.

Anti-Infective Agents, Local↗

Randomized trial comparing cryopreserved cultured epidermal allografts with tulle-gras in the treatment of split-thickness skin graft donor sites.

Cultured epidermal allografts have been successfully used to treat a wide variety of skin defects ranging from burns to leg ulcers. Their postulated mechanism of action is through release of multiple cytokines that stimulate epithelialization from the wound periphery as well as from remnant epidermal appendages. A randomized, controlled clinical trial was undertaken to compare the efficacy of cryopreserved cultured allograft dressings (CCAD) with tulle-gras dressings in the treatment of split-skin graft donor sites. Five patients were enrolled in the study and in each patient, half of the donor site was allografted and the other half was treated with tulle-gras control. The mean time to complete healing was 6.2 days for CCAD compared with 9.6 days (p = 0.035) for the tulle-gras controls. Patient assessment of pain with dressing changes was also significantly lower at the CCAD-treated sites than at the control sites (p = 0.001). The results indicate that cultured allografts offer greater patient comfort and earlier maturation of regenerated skin.

Adult↗

[Poisoning caused by external use of iodoform].

A case of iodoform toxicity caused by use of 5% iodoformed bandage in occlusive surgical dressings for tamponing of diffuse hemorrhage in pelvic cavity, following amputation for treatment of rectum adenocarcinoma. Despite the frequent use of iodoformed dressings following surgical procedures, the signs and symptoms of iodoform toxicity syndrome can be easily mistook for other syndromes. A revision of the published observations suggest that this syndrome is not as rare as thought but probably has been underdiagnosed.

Aged↗

Amniotic membrane as a biological dressing in the management of burns.

This report details observations in 90 patients with dermal depth burns treated using amniotic membrane. The patients were divided into three subgroups: superficial dermal, intermediate dermal and deep dermal burns diagnosed clinically. All patients were dressed with amniotic membrane which was changed daily. The amniotic membrane relieved the discomfort of dressing changes, postoperative pain and oozing and allowed rapid epithelialization and early healing in superficial and intermediate depth dermal burns. In deep dermal burns the membrane was dissolved because of slough in the burn wound. After removal of the slough the amniotic membrane helped in rapid regeneration of epithelium and early healing.

Bandages↗

Acetobacter cellulose pellicle as a temporary skin substitute.

A bacterial strain with morphological and biochemical properties close to Acetobacter xylinum has been cultured in nonagitated, inverted sucrose- and yeast water-based medium for the production of thick, smooth, and floating cellulosic pellicles. The cellulose content (greater than 90%, dry weight, depending on the efficiency of water washing) and the beta-D-homopolyglucan nature of these pellicles were assessed by physical, chemical, and enzymatic methods. The apyrogenic bacterial biomass, a minor component of the dried biofilm (BioFill), is inactivated by ethylene dioxide. Once applied on exudating or bloody tissues, this biofilm displays several advantages as a biological dressing, and hence, it is valuable as a temporary skin substitute in the treatment of skin wounds, such as burns, ulcers, grafts, and as an adjuvant in dermal abrasions.

Acetobacter↗

Porcine heterograft dressings for split-thickness graft donor sites.

As compared with previous methods of donor site care, procine heterograft dressings allow the donor site to heal faster, require less postoperative care, are associated with a lower infection rate and eliminate virtually all of the pain of the split-thickness wound. Our experience supports that of others. We believe our modifications of this technique to be superior to previous modalities of donor site care.

Bandages↗

[Differential therapeutic indications for the useof Xenoderm and SYSper-derm in burns and other skin defects. Commentary on the work of J. Maserova: a comparative study of several synthetic skin substitutes].

The experimental studies by Moserová yield an objective judgement of different biological and synthetic wound dressings and underline the importance of evaporation in the progression of dermal necrosis in the postburn period. Basing on the results of these findings and own experimental and clinical results recommandations are given concerning the use of Xenoderm and SYSpur-derm, both temporary skin substitutes of the GDR-production. The different indications for the application of the two materials are described.

Bandages↗

Pigskin xenograft as biologic dressing in radical vulvectomy.

Wound infection and breakdown constitute the most common complication of radical vulvectomy and groin lymphadenectomy. The use of pigskin xenograft as biologic dressing when the skin edges cannot be closed primarily without tension after radical vulvectomy and groin lymphadenectomy is described. This technique allows for clean granulation tissue to develop early (within five to seven days) and seems to accelerate the healing process. Its use has been associated with early ambulation and rapid recovery as well as a shorter postoperative stay.

Adult↗

The use of biological dressings in radical vulvectomy.

The use of biological dressing techniques accelerates recovery from radical vulvectomy combined with lymphadenectomy. Our earliest interest in the field arose as a result of the morbidity rate which ensued subsequent to surgical therapy of cancer of the vulva. The technique involved in 8 such procedures is described, and its applicability illustrated with photographic plates and review of the literature.

Aged↗

Care of the burn wound.

The initial therapy of thermal injuries is directed at removal of loose debris and necrotic epidermis, alleviation of pain, and prevention of infection. Following initial wound debridement, bacterial growth in the wound itself is controlled primarily through the use of tropical antibiotic agents and daily hydrotherapy to clean the wounds and remove any loose eschar. Effectiveness of topical therapy is monitored by quantitative burn wound biopsy cultures; growth of greater than 10(4) micro-organisms per gram of tissue indicates invasive burn wound sepsis. Such bacterial invasion may be further controlled through the adjunctive use of antibiotics administered into the sub-eschar space. Once eschar separation has exposed healthy granulation tissue, the burn wound must be covered with suitable biologic dressings prior to autografting. All open wounds may then be autografted with sheet grafts to the face, neck, and areas exposed to trauma or by expansion mesh grafts to cover large areas from limited donor sites. Upon completion of autografting, a vigorous physical therapy program is necessary to rehabilitate victims of massive thermal injury to a functional existence.

Administration, Topical↗