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At least 433 records · Page 24Linked to original sources
PubMed2004

Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D.

There is growing evidence that equine dysautonomia is a toxicoinfection with Clostridium botulinum type C. The possibility that feline dysautonomia has the same aetiology was investigated by attempting to detect botulinum type C neurotoxin in the food, faeces and the contents of the ileum of affected cats, and by serology. The toxin was detected directly in four of eight affected cats and after enrichment in seven of them, and in their dried food. No toxin was detected in healthy control cats or in their tinned food. Recent exposure to the organism was assessed by the detection of immunoglobulin A (IgA) in the faeces of healthy control cats and affected cats. The levels of IgA antibodies to the toxin and to surface antigens of C. botulinum type C in the faeces of the affected cats 14 weeks after the outbreak were significantly higher than in the faeces of the control cats.

Animal Feed↗
PubMed2005

"Collateral damage": antibiotics and the risk of Clostridium difficile infection.

Patients undergoing orthopedic surgery are at increased risk for infection, and antimicrobial use continues to be required. Antimicrobial selection, however, is an important consideration given the increasing incidence and severity of C. difficile infection described in the literature. When choosing antimicrobials for prophylaxis and treatment, evaluate patients for risk factors that may predispose them to C. difficile infection. Patients receiving multiple antibiotics or broad-spectrum antibiotics, women, patients with concurrent proton pump inhibitor use, and those with renal failure are at increased risk. Choice of antibiotics should be evaluated for their potential or likelihood to cause C. difficile infection. When a number of these risk factors are present, avoiding the use of high-risk antibiotics may be warranted.

Antibiotic Prophylaxis↗
PubMed2000

[Diagnosis of Clostridium difficile infection in pseudomembranous colitis].

C. difficile is known as the main cause of pseudomembranous colitis, however, some individuals may be asymptomatically colonized. In this paper two patients with diarrhoea had three respectively five negative stool cultures. Endoscopically, one patient had severe colitis consistent with both pseudomembranous colitis and inflammatory bowel disease. In the other case the endoscopic findings were typical for pseudomembranous colitis. In both cases there were positive cultures for C. difficile from biopsies from colon-plaques. We find that culture of biopsy of a colon-plaque may contribute to the detection of C. difficile infection in patients with negative stool cultures.

Aged↗
PubMed1990

[Clostridium perfringens infection following intramedullary nailing of an open femur shaft fracture].

In a 47-year old patient, clostridial bacteraemia and local gas gangrene developed following osteosynthesis of a penetrating femoral fracture by a medullary nail. The operation had been performed in a post-injury interval of 14 days. The first clinical symptoms did not appear until 6 days after surgery. Operative treatment by large local incisions, debridement and drainage with the medullary nail left in situ accompanied by administration of penicillin G resulted in recovery. In the case presented here, local haematoma and debris due to the osteosynthesis procedure had probably induced a proliferation of clostridia leading to gas gangrene. The delay in development of signs and symptoms and the benign appearance of the wound resulted in delay in early diagnosis and appropriate treatment of this potentially life-threatening entity. Ultrasound proved to be a valuable tool in the evaluation of local changes. Even in performed in an appropriate postinjury interval, medullary nailing bears a potential risk of inducing a clostridial infection, so that the indication must be very strict.

Anti-Bacterial Agents↗