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PubMed1974

[The size of chorionic villi in the placenta of diabetics (author's transl)].

25 placentas in maternal diabetes and 25 placentas from normal pregnancies (39- 41 th week) were investigated by histoplanimetry. In each placenta we have measured in 2 areas out of the center and the periphery the plain of villi. The total sum of villi measured comes to 10302. The investigation has shown, in the average the plain of villi in diabetic placentas is higher than in normal placentas significantly. Besides, the number of small villi decreases and the number of villi with a plain over the average rises in cases of diabetes nellitus. These differences in the distribution of the chorionic ville in some classes of size between placentas of diabetic and such of normal pregnancies are significantly too.

Birth Weight↗
PubMed1989

Prenatal diagnosis of Chinese homozygous alpha-thalassaemia 1 and haemoglobin H disease by analysis of alpha- and phi zeta-globin genes in chorionic villi and amniocytes.

Eighty-eight high-risk pregnancies, 81 for homozygous alpha-thalassaemia 1 and 7 for haemoglobin (Hb) H disease, were collected in this study. Chorionic villus sampling (CVS) was done in 63 cases and amniocentesis in 25 cases to obtain fetal cells. Southern blotting and DNA hybridization with alpha- and phi zeta-globin gene probes were used to determine the alpha-globin gene status. In two non-informative families with non-deletional mutations, DNA analysis failed to rule out the affected condition, and fetal blood sampling (FBS) and Hb electrophoresis were used for the final diagnosis. In the 81 fetuses at risk for homozygous alpha-thalassaemia 1, 17 (13 by CVS and 4 by amniocentesis) were affected, 30 were alpha-thalassaemia 1 heterozygotes, 19 were normal, and the remaining 15 were either normal or heterozygous. In the seven fetuses at risk for Hb H disease, one was normal, three were alpha-thalassaemia 1 heterozygotes, two were alpha-thalassaemia 2 heterozygotes, and one was affected with Hb H disease and developed hydrops fetalis. DNA analysis on fetal cells enabled us to diagnose prenatally severe alpha-thalassaemias, to prevent the birth of infants with Hb H disease, and to minimize maternal obstetrical complications from harbouring a fetus with Hb Bart's hydrops fetalis.

Amniocentesis↗