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At least 433 records · Page 24Linked to original sources

PubMed1985

Benefits of vaginal estriol cream combined with clonidine HCL for menopausal syndrome treatment.

In a group of 25 post menopausal women mean age 57.2 years, treatment with Estriol vagina cream (Ovestin cream from Organon-Holland) gives rise (but within normal limits) to cholesterol, triglycerides and HDL-cholesterol, the protective factor against M. I. A rise in glycohemoglobin (HbA1C) statisticaly significant was noted, as a sign of slight glucose intolerance, but in no case was there a diabetic pattern. Vaginal Estriol cream was able to prevent osteoporosis. After a few weeks of treatment urinary calcium/creatinine ratio decreased. In the light of our own findings, Ovestin being a weak estrogen does not induce endometrial proliferation or breakthrough bleeding and does not modify the blood biochemistry, and can be recommended for postmenopausal syndrome even in familial hyperlipidemia diabetes, and for prevention of osteoporosis.

Cholesterol↗

PubMed1979

Serum unconjugated estriol after intravenous cortisol administration in late pregnancy.

Serum unconjugated estriol levels were measured in 44 pregnant women treated with corticoids for the prevention of respiratory distress syndrome (RDS) in premature infants. Intravenous administration of cortisol (1 g every 6 hours for 24 hours) decreased the level of circulating unconjugated estriol to 40% of the initial value after 6 hours and to 27% after 24 hours. During the 2 succeeding days, all the results remain below the pretreatment values. On the third day, the mean value is no longer different from the control value, but in some patients recovery takes more than 3 days.

Estriol↗

PubMed1983

[Estriol skin effects--clinical, hormonal and sebum parameters in female acne patients].

The following paper presents the results of treatment of premenstrual acne with an estriol containing ointment. The mode of action of this therapy is discussed. Evaluations of serum-HPRL at regular intervals served as parameter for a possible systemic estrogen effect. A central estrogen stimulation could not be proved. For documentation of possible therapeutic effects, we performed thin-layer chromatographic sebum-determinations from treated as well as untreated areas. The same technique could give us information about the working mechanism of external estrogen treatment in telling us possible parallelisms in the course of the lipid values during therapy. The findings confirm the local efficacy of the estriol-ointment. Clinical results ranged between good and excellent in 8 out of 12 patients. In addition the number of skin lesions decreased, and the skin itself looked "improved". This form of therapy may be a possible alternative to systemic hormone therapy or a good supply in a combination therapy.

Acne Vulgaris↗

PubMed1978

Estriol in the management of the menopause.

Estriol was administered for a six-month period as estrogen replacement therapy to 52 symptomatic postmenopausal women. Assays of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrone, and estradiol were performed before and during therapy. During this period of administration, vaginal cytology, cervical mucus, and endometrial studies were performed. Clinical effectiveness was directly related to dosage (2 to 8 mg/day). Estriol (8 mg/day) failed to induce endometrial proliferation and proved a poor suppressor of FSH and LH. This agent's capacity to relieve vasomotor instability and improve vaginal maturation without notable side effects is sufficient reason to include this drug in the management of the postmenopausal syndrome.

Endometrium↗

PubMed1984

Correlation of amniotic fluid estrogens with L/S ratios and urinary estriols.

17 beta-estradiol (E2) and estriol-16-glucuronide in amniotic fluid from 87 patients (normal and stressed pregnancies) were studied with radioimmunoassays. Overall, amniotic fluid estradiol and estriol increased with gestation and paralleled the increase in the L/S ratio. Statistical correlations between amniotic fluid E2 and E3 with L/S were fair and better for E3 than for E2. Correlations were better from 31 to 35 weeks of gestation than from 36 to 40 weeks. A threshold of 0.34 ng/ml should be used for E2; levels above that possibly represent fetal maturity and well-being. A threshold of 540 ng/ml should be used for E3; levels above that possibly indicate fetal maturity and wellbeing. Urine E3 correlated poorly statistically with amniotic fluid E3. Serum E3 was not studied.

Amniotic Fluid↗

PubMed1980

Enzyme immunoassay of estriol in pregnancy urine.

We describe an enzyme immunoassay for determination of total estriol in urine. Estriol covalently bound to horseradish peroxidase is used as tracer, and free and bound hormone are separated by precipitation with polyethylene glycol. The method can be used with either acid hydrolysis at 100 degrees C for 30 min or enzyme hydrolysis at 50 degrees C for 40 min; results by the former procedure are about 15% lower than results by the latter. Results were practically identical when we compared the enzyme immunoassay with a radioimmunoassay, using the same antiserum and method of hydrolysis. The day-to-day CV for three different concentrations was 10.7-12.0%, the within-series CV 6.6-8.6%. The additional time required for the enzyme reaction is compensated for by the rapid measurement of light absorbance. Thus this method is faster than radioimmunoassay when more than 25 samples are to be assayed.

Estriol↗

PubMed1982

Total estriol in serum and plasma as determined by radioimmunoassay.

We present and discuss the results of a statistical study of a set of radioimmunoassay data obtained from parallel determinations of the total estriol content of samples of serum and plasma prepared from 98 specimens of whole blood, taken from pregnant woman. Estriol concentrations in the serum exceed by an average of 7% the values found for the plasma prepared from the same whole-blood specimen. The clinical significance of this analytical finding is discussed, and we conclude with the recommendation that serum is the fluid of choice for this assay.

Estriol↗

PubMed1982

Studies on steroids. CLXXIX. Determination of estriol 16- and 17-glucuronide in biological fluids by high-performance liquid chromatography with electrochemical detection.

A high-performance liquid chromatographic method for the determination of estriol 16-glucuronide and 17-glucuronide in bile and urine has been developed. The electrochemical detector was found to be more superior than the UV detector with respect to selectivity and sensitivity and therefore more suitable for the determination of estrogen conjugates in biological fluids. The use of the present method revealed that both estriol 16-glucuronide and 17-glucuronide were excreted in rat bile, while only the former was present in human pregnancy urine.

Animals↗

PubMed1980

Timed 12-hour specimens in outpatient estriol monitoring.

Use of maternal urinary estriol excretion to monitor fetal status is often hampered by the difficulties of obtaining 24-hour specimens. Evidence is presented that timed, 12-hour overnight specimens may be substituted for the 24-hour specimens in certain patient groups. A simple non-refrigerated transport system which facilitates outpatient estriol monitoring is also described.

Ambulatory Care↗

PubMed1980

Determination of urinary placental estriol by reversed-phase liquid chromatography with fluorescence detection.

Ww describe a liquid-chromatographic procedure for determining urinary estriol concentrations. The urine sample, after enzymatic hydrolysis to free the conjugated estrogen, is extracted with ether, and an aliquot of the resulting extraction residue is injected into the liquid chromatograph. Sample components are separated with a reversed-phase C18 column and isocratic elution with an acetonitrile/water mobile phase. Using a far-ultraviolet excitation wavelength, we measure the natural fluorescence of the eluted estrogen with a fluorescence detector. The procedure provides excellent sensitivity for determing near-term pregnancy concentrations of urinary estriol. The selectivity of the method limits the effect of potentially interfering compounds.

Chromatography, Gas↗

PubMed1980

Plasma estriol in the evaluation of third-trimester gestational age.

This study attempts to confirm previous reports of a clinically useful serum unconjugated estriol surge at 36 weeks' gestation. Although an apparently physiologic estriol surge occurred at 36 +/- 2.1 weeks in 25 of 32 patients, clinical reality makes weekly plasma sampling difficult. In individual cases, use of the "surge point" predicted gestational age within a 4-week range with only 66% accuracy, and potentially serious errors in dating occurred. Other biochemical (lecithin:sphingomyelin, phosphatidylglycerol) and sonographic methods are superior in resolving problems with dating gestational age in the third trimester.

Estriol↗

PubMed1995

[Treatment of climacteric urogenital disorders with an estriol-containing ointment].

Estriol containing cream for treatment of climacteric urogenital complaints was used. After 4 weeks local treatment with Ovestin cream atrophy of vaginal epithelium and chronic vaginitis stopped or significantly decreased. During the treatment the ratio of superficial and intermedier cells in the vaginal epithelium increased and the vagina showed a decrease of pH. The subjective complaints relating to the estrogen deficiency (vaginal burning and dryness, itching, dyspareunia and urinary dysfunctions) ceased. Side-effects and complications during the treatment were not found. The cream can easily be used and it is well tolerated. Estriol containing cream is suitable for the treatment of chronic vaginitis and cystitis developed on the base of climacteric epithelium atrophy of urogenital system. Its introduction to the local therapy is necessary because the majority of population of women are interested in it.

Administration, Topical↗

PubMed1993

[Cytologic response of the irradiated vagina to estriol succinate].

The vaginal response to estriol succinate was studied in 40 oncogynecological patients, 20 with irradiation (study group) and 20 without irradiation (control group). Both groups had artificial established menopause at the beginning of the treatment. The previous clinical and cytological patterns to estrogen therapy were more severe in the irradiated group; they presented the highest degree of vaginal atrophy which was related to the type and therapeutic dose used. Response of the study group to a continuous 4 mg of estriol as well as the control group, both has a positive effect in vaginal cytology and alleviates postmenopausal symptoms and improve the quality of life.

Adult↗

PubMed1977

Determination of placental estriol in urine by gas-liquid chromatography, with equilenin as internal standard.

Placental estriol in urine can be determined by rapid enzymatic hydrolysis, extraction with neutral XAD-2 resin, and quantitation by gas-liquid chromatography, with equilenin as the internal standard. Glucose, methenamine mandelate, hydrochlorothiazide, phenolphthalein, or salicylate do not interfere. Analytical recovery of estriol added to urine was 92-108%. Day-to-day precison (CV), established by 15 repilicate analyses at a mean concentration of 21.3 mg/liter, was 6.6%.

17-Ketosteroids↗

PubMed2001

Elevation of serum 17-beta-estradiol in channel catfish following injection of 17-beta-estradiol, ethynyl estradiol, estrone, estriol and estradiol-17-beta-glucuronide.

17-beta-Estradiol is naturally converted in numerous organisms to various derivatives/metabolites, which may be excreted from the organism into its immediate external environment. There is a paucity of data regarding the biological effects of these derivatives/metabolites on aquatic organisms. Male channel catfish (200-500 g, N=5, 12-18 months) were injected with 1 mg/kg 17-beta-estradiol (E2), ethynyl estradiol (EE2), estrone, estriol or E2-17-beta-glucuronide with subsequent measurements of vitellogenin (Vtg) and serum E2 concentrations 7 days post injection. EE2 and E2 gave the largest magnitude of Vtg response followed by estrone and estriol. Exposure to EE2, estrone, and E2-17-beta-glucuronide all induced significant increases in serum E2 concentrations. This study indicates that metabolites of E2 are also estrogenic and may potentially disrupt estrogen feedback loops within aquatic organisms.

Journal Article↗

PubMed1976

Leukocyte alkaline phosphate determinations and urinary estriol excretion in normal and pathologic pregnancies.

A comparison of the results of two assays for monitoring fetal well-being in normal and pathologic pregnancies is described. Concomitant leukocyte alkaline phosphatase (LAP) score determinations and 24-hour urinary estriol excretion were preformed in the same groups of pregnant women from the 31st week of pregnancy onward. There were 45 women with normal pregnancies, 10 women with antepartum death, 8 women in whom the membranes ruptured at least 30 hours before the determination, 40 women with moderate or severe preeclampsia and 26 women with postmaturity. Determination of LAP score is an easy, rapid and inexpensive method which can be performed in every laboratory. The results are as reliable as estriol determination. Thus LAP score may serve as a valuable method for evaluation of fetal well-being.

Alkaline Phosphatase↗

PubMed1987

Effects of estriol administration on human postmenopausal endometrium.

Forty eight women with atrophic endometrium were treated with estriol, 1 mg twice daily, by mouth for a minimum of 10 days and a maximum of 25 days. Vaginal hysterectomy was then performed and specimens were examined histologically. Results showed that estriol produces endometrial hyperplasia in 70.8% of the examined women; only 29.2% of the patients retained atrophic endometrium after treatment.

Aged↗

PubMed1976

Identification of conjugated estrogen metabolites in dog plasma following administration of estriol-2,4,6,7-3H.

Following the constant infusion of 2,4,6,7-3H-estriol in male dogs for a period of 90 minutes, the radioactive metabolites present in arterial plasma were separated by solvent partition, DEAE-Sephadex, Celite partition and thin layer chromatography. The identities of the individual estrogens and estrogen conjugates were confirmed by specific activity determinations after chromatography in several different solvent systems, enzyme hydrolysis and chromatography of the unconjugated steroids and their derivatives.

Animals↗