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[Iatrogenic thyroid diseases].

The authors investigated the patients of an ambulant dispensary for patients with diseases of the thyroid gland in the endemic district Dresden for cause, kind and frequency of iatrogenic diseases of the thyroid gland and in 13.1% of the patients they found such lesions which above all are conditioned by wrong use of thyroid hormones and thyreostatics. The foundation of special dispensaries is demanded.

Dose-Response Relationship, Drug↗

[Iatrogenic pathology (on the basis of necropsy materials in Leningrad in 1988)].

The incidence of iatrogenic diseases on the basis of necropsy materials in Leningrad in 1988 is 1.2% (168 of 13928 necropsies). The categories (I, II, III) for the evaluation of the severity degree of iatrogenic diseases are suggested. The I category includes iatrogenic diseases which were the cause of death (58 cases or 0.41% of total number of necropsies). The II category: iatrogeny is not connected directly with the main disease but facilitated the development of severe complications (87 cases--0.62%). The III category: iatrogenic diseases did not play a considerable role in the thanatology. The necessity is underlined to discuss iatrogenic pathology at the clinicopathologic conferences establishing its causes and the degree of severity.

Autopsy↗

[The diagnosis of drug-induced hepatopathies].

The present paper reports on the recent possibilities of diagnosis in iatrogenic diseases of the liver. The iatrogenic diseases of the liver are diagnosed with difficulty since no clinical, biological and histological pathognomonic criteria are known. The hepatic lesions appearing after drug intake are extremely various, including: hepatocellular necrosis, cholestasis, hepatic granuloma, perisinusoid fibrosis, steatosis, pseudoalcoholic lesions, vascular lesions and hepatic tumours. Clinical criteria, very important for the diagnosis, are based on: appearance of the disease, regression of symptomatology when the treatment is interrupted and recurrence when it is administered again. The biological criteria are not specific but they may indicate the drug etiology of a liver disease. Increase in the serum concentration of aminotransferases might be the only biochemical disturbance and it might be overlooked if not systematically investigated. The immunological tests suggested for diagnosis of iatrogenic liver diseases are numerous but only a few of them are specific. Histological criteria cannot identify, for sure, the drug etiology of the lesions. They may suggest the possibility of a drug induced cause and may help in establishment of a correct diagnosis.

Chemical and Drug Induced Liver Injury↗

5.1 The demography of oral diseases, future challenges and the implications for dental education.

This Section considered the immense challenges presented by the changing demography of populations (in particular, cross-boundary flow), changing oral and dental disease trends. It also considered the difficulties of gathering data on such information. It then considered how these challenges may affect the education of the dental team in the future. The Section considered the concept of the 'global village' as a representation of the changing world demography. We were at pains to recognize that our role was in considering both emerging and established market economies. In fact, a major part of the Section's activities concentrated on the development of the professional ethic of social responsibility - represented at the local, regional, national and international levels. We considered a finite group of oral and dental diseases, namely dental caries, periodontal diseases, oral cancer and cranio-facial disorders. In addition, we chose to comment on systemic diseases influenced by oral diseases, oral diseases influenced by systemic diseases and iatrogenic diseases (including prion disorders and cross-infection control issues). The Section recognized the profound difference between needs and demands in the provision of oral and dental health care. We considered the concept of best practices within our working remit and named these as: * the gathering of valid data on health trends; * uniformity in the measurement of disease and diagnostic parameters; * the identification of a core curriculum which best addresses an increased awareness of changing demography; and * a multidisciplinary approach to education and research in the context of global collaboration. The Section recognized the enormous potential for global networking with the explosion of information and communication technology. We investigated the requirements in converging towards higher global standards, while accepting and appreciating important regional and continental differences. To this end, the Section has put forward a number of important recommendations and realistic goals.

Computer Communication Networks↗