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At least 433 records · Page 24Linked to original sources
PubMed1990

Thrombin-induced serotonin release as an in vitro indicator of the functional integrity of stored platelets.

Measurements of endogenous serotonin and the thrombin-induced serotonin release reaction in platelet concentrates were compared with other methods of quality control: particle counting and pH and gas analyses. A discrepancy between the serotonin release reaction and the other data was observed after seven days of storage. The decline in the release reaction was not predictable from pH measurements or the number of platelets or leukocytes in the concentrate. There was a significant positive correlation between endogenous serotonin content and the thrombin-induced serotonin secretion after seven days of storage. We conclude that the current methods for routine control of platelet concentrates may not ensure the quality of the product after it has been stored for seven days. The thrombin-induced serotonin release may provide a valuable addition to the battery of tests available.

Blood Gas Analysis↗
PubMed1988

[Preservation of the functional integrity of cellular material after cell microencapsulation by polymerization].

A new process for microencapsulating living cells is described. A cross linked network was polymerized using acrylamide and bisacrylamide monomers round agarose-embedded cells in an hydrophobic medium. The reaction was initiated by excitation of Vit. B2 under visible irradiation. The absence of toxic effect was evaluated from the insulin secretion of encapsulated islets of Langerhans.

Animals↗
PubMed1987

[Electrophysiological indices of the degree of functional integration of a cortical transplant with the brain of the recipient].

Pieces of the embryonal rat neocortex were grafted into the cavity at the place of the barrel-field of adult rats. Neuronal discharges and slow activity were recorded in 11 grafts 3-8 months after the grafting. Neurons of nine grafts responded to vibrissae deflection, their background activity consisted of randomly distributed discharges as in the normal cortex. The similar slow activity was observed in the responding grafts and in the host's intact contralateral barrel-field. Neurons of two grafts did not respond to vibrissae deflection. Hypersynchronous discharges prevailed in their background activity as well as slow delta-waves and epileptiform sharp spikes and waves. Complexes predominated in slow activity of these grafts. Histology revealed a close contact between responding grafts and host brain tissue. Nonresponding grafts were separated from the host brain by a thick glial scar which apparently prevented the axonal exchange between them.

Acoustic Stimulation↗