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At least 433 records · Page 24Linked to original sources
PubMed1991

[Clinical aspects and treatment of recurrences of lymphosarcoma in children].

Overall 392 patients with lymphosarcoma were under observation from 1980 to 1989 at the department of childhood hematology, All-Union Cancer Research Center, USSR AMS. The patients were characterized by the moment of the disease diagnosis. During treatment, 70 patients (31%) developed disease relapses. The relapses were characterized, possible causes of their development were analyzed. The results of relapses treatment according to two programs are discussed. No increase of the survival of the patients with relapses due to the intensification of the treatment programs was noted.

Adolescent↗
PubMed1991

[The expression of lymphopoietic differentiation antigens on the membrane of the peripheral blood mononuclear cells in lymphosarcoma tumor progression].

Monoclonal antibodies were used in the indirect immunofluorescence test to assay the antigenic features of lymphoid cells in patients with lymphosarcoma. Some patients with progression of lymphoblastic lymphoma showed an increased content of T lymphocyte expressing early activation antigens, antigens of early hemopoietic progenitors, and CALLA-antigens.

Antibodies, Monoclonal↗
PubMed1977

Bovine lymphosarcoma in twin calves.

Lymphosarcoma in twin female calves, apparently the first to be observed in Canada, is reported here. Peripheral blood and cultured mononuclear cells of one of the calves showed aneuploidy of the chromosomes. No hematological or serological evidence of bovine leukemia virus infection was observed in the other members of the herd. Bovine leukemia virus infection of the leukemic cells could not be detected by electron microscopy or by tissue culture procedures. There is a need to clarify the relationship of the calf form of the disease to the adult form of enzootic bovine leukosis.

Animals↗
PubMed1978

[Control of lymphosarcoma or leukaemia in cats and of feline leukaemia virus (author's transl)].

A removal programme, specially designed for catteries or multiple cat households, to reduce the incidence of lymphosarcoma or leukaemia in cats and the spread of feline leukaemia virus (FeLV), is discussed. This removal programme includes annual testing of male stud cats, testing all contacts of FeLV-positive cats they had during the past two years, testing cats imported from abroad and isolation--or, if this is not possible, euthanasia--of cats found to be positive for FeLV-antigen. To detect the FeLV-antigen a simple indirect fluorescent antibody technique (FAT) was used to detect FeLV-antigen. During a period of four years, the following results were obtained when a removal programme was carried out by a large cat breeders' association in the Netherlands. The proportion of catteries, in which FeLV-positive cats were found to be present, decreased from 11.5 per cent in the former half of 1974 to 2.1 per cent in the latter half of 1977. The proportion of FeLV-positive cats and male studs decreased from 4.9 per cent to 1.2 per cent and from 5.9 per cent to 1.0 per cent respectively during this period. It is concluded that the recommended removal programme is a simple and successful procedure.

Animals↗
PubMed1990

T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops).

A female African green monkey developed a generalized lymphosarcoma spontaneously that clinically and pathologically resembled malignant lymphoma in human beings infected with human T-lymphotropic virus type I. The monkey was serologically positive for simian T-lymphotropic virus. Immunocytochemical analysis of routinely fixed and paraffin embedded tumor tissue demonstrated neoplastic cells that stained positive with antihuman monoclonal UCHL1 which recognized a T-cell-restricted isotype of leukocyte common antigen.

Animals↗
PubMed1990

Hypercalcaemia and soft tissue mineralisation associated with lymphosarcoma in two horses.

Two horses with deposits of lymphosarcoma, one in the spleen, the other in the mediastinum, several lymph nodes and kidneys, lost weight rapidly and became depressed and weak. They were hypercalcaemic and post mortem examination revealed extensive calcification of the heart and major vessels. There was no evidence of bone marrow metastases in the one horse whose marrow was examined, and the thyroid and parathyroid glands of both horses were grossly normal.

Animals↗
PubMed1990

[Bilateral lymphosarcoma of the orbit and the eyes].

The author describes two cases of bilateral lymphosarcoma of the lacrimal glands and eye. Taking into account a tumor tendency to generalization, x-ray investigation of the bones with Tc-pertechnetate and blood analysis are found necessary. A method of gamma-beam therapy is described.

Combined Modality Therapy↗
PubMed1990

Vertebral lymphosarcoma in a cat.

Lymphosarcoma of the cauda equina in a domestic shorthair cat invaded the body of L7 and cranial portion of the sacrum. Clinical signs consisted of acute ambulatory paraparesis, tail paralysis, and dyschezia. Radiographically, there was evidence of bone lysis. Surgical exploration yielded a diagnosis, but did not induce improvement in the cat, which was subsequently euthanatized. Neurologic signs were similar to those associated with sacral nerve root avulsion injuries in cats.

Animals↗
PubMed1989

Remission of FeLV-associated lymphosarcoma and persistent viral infection after extracorporeal immunoadsorption of plasma using staphylococcal protein A columns: details of immune response.

Sixteen feline leukemia virus (FeLV)-infected cats with lymphosarcoma (LSA) were treated by extracorporeal immunoadsorption using staphylococcal protein A columns in order to remove immunoglobulin G (IgG) and circulating immune complexes (CIC) from plasma. Complete viral clearance and long-lasting tumor regression were achieved in nine of the cats and tumor regression without virus clearance was observed in two other cats. Since LSA cats rarely go into spontaneous remission, and since other forms of therapy are ineffective, these cats offered a unique system for analyzing details of the immune response to LSA and FeLV as they are cleared. Immunological parameters associated with the FeLV and LSA responses were assessed in detail in three responder cats and three nonresponders during the treatment and follow-up periods. Two serological parameters that always correlated with complete clearance of LSA were development of precipitating antibodies against FeLV-C gp70 and development of cytotoxic antibodies that kill cultured FL74 LSA cells in the presence of complement. The precipitating antibodies were detected prior to the clearance of LSA and prior to the detection of free cytotoxic antibodies. One serological parameter that always correlated with complete clearance of. FeLV was development of free antibodies to FeLV-AB gp70. Quantitative levels of FeLV-specific CIC and feline oncornavirus-associated cell membrane antigen (FOCMA)-specific CIC correlated well with fluctuating levels of the corresponding antigens and antibodies. These results suggest that the staphylococcal protein A treatment columns remove CIC "blocking factors" directly or indirectly and thereby stimulate existing antibody responses. These antibodies mediate clearance of FeLV and LSA.

Animals↗
PubMed1989

[Decrease in the growth rate of Ehrlich's tumor and Pliss' lymphosarcoma with partial hepatectomy].

In experiments with transplantable tumors, partial hepatectomy, Rhodiola rosea extracts or their combination were shown to inhibit the rate of Ehrlich's tumor and Pliss' lymphosarcoma as well as dissemination of the latter. These effects are to a certain extent attributed to production of humoral factors by the liver inhibiting clonogenic activity of tumor cells in vivo and in vitro.

Animals↗
PubMed1989

Lymphosarcoma with disseminated skeletal involvement in a pup.

Lymphoblastic lymphosarcoma with disseminated skeletal involvement was diagnosed in a 15-week-old Golden Retriever. The skeletal disease was characterized by diffuse, irregular areas of radiolucency most evident in the diaphyseal portion of long bones and was associated with gait abnormalities and signs of pain. Necropsy also revealed involvement of the spleen, liver, kidneys, and mesenteric lymph nodes.

Animals↗
PubMedDate not supplied

[The effect of 5-fluorouracil, metronidazole, caffeine and irradiation on the synthesis of DNA in the Pliss lymphosarcoma].

Injection of 5-fluorouracil or caffeine or a combination of each of them with metronidazole removes partially or wholly the postirradiation arrest of DNA synthesis in Pliss lymphosarcoma and increases the label index and (or) the rate of its incorporation in nuclei of DNA-synthesizing cells compared to irradiated controls. The administration of the three agents arrests almost completely the DNA synthesis during the very first hours following irradiation, then prematurely removes partially the synthesis block in most DNA-synthesizing cells.

Animals↗
PubMed1989

[Pathologic anatomy of subtypes of immunoblastic lymphosarcoma].

Morphological parameters for immunoblastic lymphosarcoma (IL) subtypes: plasmocytic IL (PIL) and polymorphocellular IL (PMIL) were determined through a comparative morphological analysis of 56 sections and 64 respective diagnostic biopsies. PIL was found to more frequently affect the gastrointestinal tract. Tumors were found to be selective in damaging the organs, e.g. white pulp was affected in PIL, marginal follicular areas, in PMIL. Clinical and anatomical analyses of the death causes in patients with IL showed that they all had died of neoplastic progression (67.9%), concurrent diseases (23.2%) or complications resulted from the therapy performed (8.9%) upon tumor progression.

Adolescent↗
PubMed1978

Phase II clinical trial with vindesine for remission induction in acute leukemia, blastic crisis of chronic myeloid leukemia, lymphosarcoma, and hodgkin's disease: absence of cross-resistance with vincristine.

Vindesine, an analog of vinblastine and vincristine, has been submitted to a phase II trial, the results of which are judged in terms of remission induction. A high proportion of remissions were obtained in acute lymphoid leukemia and blastic crisis of chronic myeloid leukemia, and a few responses have been registered in lymphosarcoma and Hodgkin's disease. A continuous 48-hour iv infusion may induce a remission where an iv push of the same dose has failed. The most remarkable characteristic of vindesine is the absence of cross-resistance with vincristine as documented in acute lymphoid leukemia.

Acute Disease↗
PubMed1988

An outbreak of lymphosarcoma in merino sheep in the South Western Cape.

Ten per cent of a flock of 481 Merino sheep died from suspected lymphosarcoma in the Caledon district, during a period of one year. In 9 sheep the diagnosis was confirmed by histopathological examination of the tumours. All the sheep and the cattle on the farm were tested for enzootic bovine leukosis using a Bovine Leukemia Glycoprotein Immunodiffusion kit. At the first test 20.5% of the sheep had antibodies to enzootic bovine leukosis. A control programme resulted in a drop in infection rate (3%) within 17 months.

Animals↗
PubMed1988

Changes in metabolism, food and water intake of C3H mice following transplantation of Gardner lymphosarcoma (LSG).

Mice bearing progressing Gardner lymphosarcoma (LSG) increasingly gained in weight in the course of LSG development but their food and water consumption was reduced in comparison with control animals. During the neoplastic growth, oxygen consumption was decreased and the proportion of the metabolically active part (i.e. dried matter) declined. The body weight of tumour-bearing mice successfully cured with methotrexate (MTX) (30 mg/kg body weight, administered on days 1 and 3) was substantially lower than those of non-treated tumourous animals and was similar to that of intact controls. The food and water consumption of mice treated with MTX and that of control animals was similar. Values of the metabolic rate observed in animals treated with MTX were comparable to those recorded in the control group.

Animals↗
PubMed1985

[Factors reducing the superoxide dismutase activity of the liver of rats with Pliss lymphosarcoma].

The procedures for isolation and purification of Cu/Zn superoxide dismutase (SOD) from small amounts of rat liver at different stages of Pliss lymphosarcoma growth were developed. Two stages of tumour growth were distinguished. At the first stage (4-5th day after reinoculation) the intensity of optical (680 nm) and EPR spectra of SOD was decreased, on the average, to 30%, while at the second stage--by 40% at 680 nm and by 32%, at 260 nm. The intensity of the EPR spectra was also diminished by 40% as compared to the control. It was assumed that at initial stages of tumour growth the decrease of the SOD activity is mainly due to the reduction of enzyme Cu, while at the second stage--to the decrease of the protein content. In all probability, the observed changes are induced by the activation of lipid peroxidation involving active O2 species. The second stage is associated with the superoxide-induced impairment of the function of nucleic acids involved in protein biosynthesis.

Animals↗