PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Lactose Tolerance Test”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 433 records · Page 24Linked to original sources
PubMed2001

Residual intestinal disease after milk allergy in infancy.

BACKGROUND: The subsidence of cow's milk allergy (CMA) has been a subject of controversy. In this study the authors examined whether children with this condition in infancy developed full tolerance or whether they continue to have vague gastrointestinal (GI) symptoms relating to the consumption of milk or dairy products and/or signs of mucosal lesion in the GI tract. METHODS: The authors reexamined 56 10-year-old subjects who manifested CMA before 1 year of age, and compared the results with a group of 204 randomly selected age-matched school children. Fifty-three and 90 subjects respectively attended a reexamination and were evaluated for growth, lactose tolerance, and immunoglobulin A (IgA)- and IgG-class antibodies to whole cow's milk. The subjects reporting milk-related GI symptoms were encouraged to do a 4-week blind elimination-challenge test with 1 week of low-lactose milk flour. Sixteen of the 25 children were able to complete the trial. RESULTS: Approximately half the study subjects (45%) reported milk-related GI symptoms, whereas the respective figure among the control subjects was 10%. Three of six study subjects and seven of 10 control subjects, although completing the challenge, responded with intestinal symptoms. The growth of the former CMA subjects was retarded compared with the control subjects, and the difference in height was most striking in those subjects still reporting milk-related GI symptoms. However, all subjects had normal hemoglobin and whole-blood folic acid levels. The CMA subjects had significantly (P = 0.014) lower concentrations of milk antibodies compared with the control subjects. Lactose malabsorption, defined as high counts in a hydrogen breath test and related clinical symptoms, was found in eight CMA subjects (14%) and six control subjects (3%). CONCLUSIONS: In a certain proportion of subjects with CMA in infancy, GI intolerance seems to persist even after small-dose tolerance has been achieved. The intestinal symptoms and the increased prevalence of lactose intolerance may be caused by a disturbance of the surface epithelial cells--a state to which the authors refer as residual intestinal disease.

Animals↗
PubMed1983

Inhibition of alkaline phosphatase activity by glucose.

Non-enzymatic glycosylation (NEG) of alkaline phosphatase (AP) was studied after short- and long-term incubation with glucose and other carbohydrates. Glucose and amino sugars clearly inhibited the enzyme activity; this was in contrast to reducing and non-reducing disaccharides, which had an enhancing effect. After AP had been incubated with 18 nmol/l glucose for 180 minutes (short-term incubation), a subsequent extensive dialysis revealed full recovery of the enzymatic activity. This, plus the demonstration of a [3H]sodium borohydride-reducible glucose-protein adduct, indicated that initially a labile aldimine (Schiff base) had been formed. Binding experiments with [14C]glucose and failure of dialysis to achieve a recovery of enzymatic activity after long-term incubation suggested that subsequently a stable ketoamine product had been formed. This was further confirmed by the thiobarbituric acid test, which revealed 0.65 nmol 5-hydroxymethylfurfural/mg protein for glycosylated AP compared to 0.11 for the non-glycosylated control. Preliminary results further suggest that NEG of AP also occurs in vivo. Streptozotocin diabetic rats had significantly lower serum AP activities than did non-diabetic controls (mean +/- SD: 153.7 +/- 28.4 vs. 760.5 +/- 95.7 U/l; p less than 0.001). Blood glucose levels and serum AP activity, which had been determined simultaneously during an oral glucose tolerance test, showed without exception an inverse relationship in each of 32 healthy children studied. The biological significance of these findings remains to be established.

Adolescent↗
PubMed1979

Lactose intolerance in Iran.

One hundred five Iranian subjects, ranging in age from 4 months to 25 years, were tested for lactose absorption and tolerance. After ingesting a lactose dose, on the basis of low blood glucose response, 68% of the subjects were malabsorbers. Prevalence of lactose malabsorption increased with age, i.e., 31% of the children less than 3 years of age malabsorbed lactose, whereas 86% of adults did so. Clinical manifestations of lactose intolerance were shown by 39% of all subjects; of those who were lactose malabsorbers, only 57% manifested clinical symptoms. Among the lactose malabsorbers, the lowest prevalence of clinical symptoms occurred among the children less than 3 years of age and the highest in adults.

Adolescent↗
PubMed1988

Effect of milk and lactose on zinc absorption in lactose-intolerant postmenopausal women.

We evaluated the effect of lactose intolerance on intestinal zinc absorption under various test conditions in a group of postmenopausal women. Fractional zinc absorption was studied with a dual-isotope technique using 65Zn and 51Cr (as nonabsorbable fecal markers). We performed four absorption tests on sixteen subjects with water (control), whole cow milk, lactose-free cow milk and lactose alone. Mean (+/- SEM) fractional zinc absorption was 0.558 +/- 0.032 with water, 0.276 +/- 0.031 with milk, 0.246 +/- 0.028 with lactose-free milk and 0.564 +/- 0.051 with lactose. No significant differences in zinc absorption were found under any of the test conditions between lactose-tolerant and lactose-intolerant subjects. Milk and lactose-free milk significantly reduced zinc absorption in both groups.

Aged↗
PubMedDate not supplied

[Metabolic markers of chronic liver disease].

The association between chronic liver disease and plasmatic lipids and glucidic metabolism was studied. The liver was evaluated with biochemical variables, ultrasound and upper gastrointestinal endoscopy. 12 chronic liver diseases patients and 10 normal were studied. 83.3% of patients showed lipidic abnormalities, 66.6% on the cholesterol levels and 41.7%, reduced HDL. When patients received 100 gr of glucose the response was abnormal in 83.3%. These results were compared with other "liver function test". 75% had abnormal bilirubin, 58.3% abnormal albumin, prothrombin time 58.3%, aminotransferases 75%. Esophageal verices were found in 75% of cases and ultrasound abnormalities in 91.6% (27.3% cirrhosis, 54.4% diffuse abnormal patter and 18.2% splenomegaly). These findings show that lipidic and glucidic metabolism, and ultrasound, in chronic liver diseases are the more frequent abnormalities.

Adult↗
PubMed1988

Lactose malabsorption in adult patients with Crohn's disease.

In order to evaluate, in adult patients with Crohn's disease (CD), the prevalence of lactose malabsorption and intolerance, and the percentage who can tolerate a physiologic amount of milk in their diet, we tested 37 patients with CD (19 with intestinal resection, and 18 without) and 67 healthy controls (C) with the H2-breath test after they had ingested increasing loads of lactose as 10% solution (12.5 g, 25 g, and 50 g). Patients with malabsorption after the 12.5-g dose were tested further with 250 ml of milk. In the total group of patients and in the subgroup of those with resection, the prevalence of malabsorption was higher than in controls at all lactose loads; in patients who had not undergone resection, no significant difference was observed with the 12.5-g dose. Eleven of 18 patients who were malabsorbers with the 12.5-g dose had malabsorption also with 250 ml milk; however, only three of them (8% of the total group) experienced symptoms of intolerance. We conclude that, in adult patients with CD, 1) the prevalence of lactose malabsorption is increased, 2) in patients who have undergone intestinal resection, malabsorption occurs at a lower dose of the sugar than in patients who did not, and 3) since only 8% of patients experienced symptoms of intolerance after the ingestion of milk 250 ml, this amount can be empirically inserted in the daily diet of an adult with CD.

Adolescent↗
PubMed1988

Relationship between milk lactose tolerance and body mass in teenage Tswana schoolchildren.

The Tswana and other black races of southern Africa have a high prevalence of the adult type of primary lactose intolerance. It is possible that nutritional status may affect lactose absorption, so that lactose malabsorbers may be less well nourished than lactose absorbers. However, such a poor nutritional status may have caused, or have been caused by, the lactose malabsorption. It is also possible that another factor, such as chronic diarrhoea, may cause both poor nutrition and lactose intolerance. A random sample of 92 Tswana pupils was taken from a school population of 486. Their heights and weights were measured, and the relative weight and body mass index (weight/height2) calculated for each subject. A milk tolerance test was administered to each subject to establish whether they were lactose tolerant or intolerant. There were 79 (85.9%) lactose intolerant subjects, 7 (7.6%) were probably intolerant and only 6 (6.5%) were lactose tolerant. The nutritional status of the lactose intolerant and tolerant subjects were compared. The two groups did not differ in nutritional status, as measured by their relative weights and body mass indices, and were nutritionally similar to a reference population of Tswana schoolchildren.

Adolescent↗