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At least 433 records · Page 24Linked to original sources
PubMed2005

Alterations of liver function test indices of filling station workers with respect of genetic polymorphisms of GSTM1 and GSTT1.

To determine the health effects of gasoline exposure on liver function test indices of filling station workers the present study was done. This case-control study was conducted in Shiraz on 56 male gasoline workers and 56 age- and sex-matched control subjects with no occupational exposure to gasoline. To elucidate the role of hepatic detoxifying enzymes, the genotypes of glutathione-S-transferases (GST) M1 and T1 were determined. Data analysis was done by multiple linear regression analysis and non-parametric Kruskal-Wallis test. The present study showed that all measurements were in normal range, although sub-clinical changes were detected in some indices. In liver function tests, exposure was associated with lower serum albumin (t=-3.88, P<0.001) and total proteins (t=-3.016, P=0.003) but higher alanine aminotransferase (t=2.856, P=0.005) and aspartate aminotransferase (t=2.11, P=0.038) levels in workers comparing to controls. Other investigators reported that GSTs involved in detoxification of several toxins including some of the compounds present in gasoline. Therefore, the possible influence of GSTT1 and GSTM1 genetic polymorphisms on alteration of liver function tests indices was investigated. The present findings showed that the genotype combinations of GSTM1 and GSTT1 did not alter the effects of exposure to gasoline in workers except for serum albumin. Serum albumin significantly decreased in workers with both active GST enzymes who had more than 5 years of employments (P=0.01). It is suggested that GSTM1 and GSTT1 are not involved in detoxification of toxicants present in gasoline which are hazardous to liver. Overall, due to detection of sub-clinical changes in hepatic test in gasoline station workers, exposure limitation and administrating safety device are recommended.

Adolescent↗
PubMed1996

Elevated liver function tests in a case of moderate ovarian hyperstimulation syndrome.

Ovarian hyperstimulation syndrome is a recognized complication of ovulation induction. Abnormalities in liver function have been considered to be a rare manifestation of the severe form of ovarian hyperstimulation syndrome (OHSS). A 28 year old woman with primary infertility underwent ovulation induction and intrauterine insemination. She was diagnosed with moderate OHSS and was followed as an outpatient. Early in her course of treatment she complained of upper right quadrant pain. Her work-up included an upper right quadrant ultrasound which showed only moderate ascites. Liver function tests at that time were elevated in a hepatocellular damage pattern. Liver function test elevations, as well as the ovarian hyperstimulation, resolved spontaneously in 10 days. Transient abnormalities in liver function do not appear to be limited to the most sever forms of OHSS.

Adult↗
PubMed1982

Clinical significance of blood biochemical liver function tests in asymptomatic chronic HBs Ag carriers.

To date we have had 31 asymptomatic chronic HBs Ag carriers in whom the time of HBV infection can be assumed, HBs Ag in sera persisted for at least 6 months, laparoscopy with liver biopsy was performed within 6 to 21 months after the assumed HBV infection, and the clinical course after performance of laparoscopy with liver biopsy ranged from 6 months to 5 years has been observed, while with the lapse of time, blood biochemical liver function tests were examined once every 4 weeks. In 16 out of 31 cases, the results of blood biochemical liver function tests remained always in the normal range and in the remaining 15 cases, blood biochemistries fluctuated sometimes pathologically, but transiently. In the former group, the results of blood biochemical liver function tests showed no pathologic findings, although the histologic inflammatory processes were outstanding in cases of chronic aggressive hepatitis and liver cirrhosis. In the remaining 15 cases, blood biochemistries fluctuated transiently and slightly, although morphological findings corresponded to chronic aggressive hepatitis and liver cirrhosis. The dissociation between blood biochemistries and morphologic findings needs to be further clarified.

Adult↗