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At least 433 records · Page 24Linked to original sources
PubMed2004

Occupational contact dermatitis from a grease.

BACKGROUND: Contact allergy to grease is rare and often not even suspected. We investigated such a case in which the detected allergen was the stabilizer in the grease, which is rarely found as an allergen. OBJECTIVE: Thin-layer chromatography (TLC) was used in a novel way and helped detect the allergen. METHODS: Patch testing with our standard series, a metal-working series, the different substances individually, the grease in serial dilution and extracts of personal objects, the TLC plate. Gas chromatography-mass spectrometry was also used. RESULTS: Test results indicated contact allergy to grease containing N-phenyl-1-naphthylamine and contact allergy to Disperse Orange 1, N-cyclohexyl-N'-phenyl-4-phenylenediamine, N-isopropyl-N'-phenyl-4-phenylenediamine, and N,N'-diphenyl-4-phenylenediamine. CONCLUSION: N-phenyl-1-naphthylamine was the main cause of the patient's dermatitis. This case report underlines the importance of testing the patient's own products and also underlines the benefit of using TLC strips for patch testing and of visiting the workplace to get correct information about exposure conditions.

1-Naphthylamine↗
PubMedDate not supplied

Patch testing for occupational allergens and the evaluation of patients with occupational contact dermatitis.

With the expanding interest in the environmental causes of disease, carefully performed, differential patch testing in suspected cases of contact allergy becomes a vitally important part of the investigation. Although all of the necessary allergens have not yet been released by the FDA for U.S. manufacture and distribution, it is hoped this will occur within the next few months. The thousands of patients with work-related allergic contact dermatitis can then hope for to learn the exact source of their disease, which can then lead to suitable work adjustments.

Allergens↗