PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Rh Isoimmunization”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 433 records · Page 24Linked to original sources
PubMedDate not supplied

Patterns of change in early neonatal nucleated erythrocyte counts in preterm deliveries.

OBJECTIVE: To examine whether changes in nucleated erythrocyte (nRBC) counts in the early neonatal period can distinguish between causes of nRBC release. METHODS: From a data set of 465 nonanomalous singleton live births delivered at 22-32 weeks, excluding maternal diabetes mellitus, Rh isoimmunization, and chronic hypertension, 125 cases had a complete blood count with an nRBC count within 3 hours of life and at least one other value obtained within 48 hours of the first. The change in nRBC count per deciliter was calculated (delta nRBC) and was correlated with antenatal fetal assessment, neonatal outcome variables, and placental histopathology in five categories: 1) histologic acute intrauterine inflammation, 2) uteroplacental vascular lesions, 3) intraplacental vasoocclusive lesions, 4) chronic inflammation, and 5) coagulation-related lesions. RESULTS: There were 92 cases (74%) of premature rupture of membranes (PROM) and preterm labor/intact membranes (PTL) and 33 cases (26%) of preeclampsia. In PROM/PTL, multivariate analyses demonstrated that a higher uteroplacental vascular lesion score was related to more stable nRBC counts (P = .009), whereas a higher nonmyeloid count in the initial neonatal white blood cell count was related to a more rapid decrease in delta nRBC (combined r = 0.54, P < .0001). No features were related to delta nRBC in preeclampsia. CONCLUSION: In PROM/PTL, but not in preeclampsia, patterns of change in the nRBC count in the early newborn period vary with uteroplacental vascular lesions and acute inflammation. This may reflect differences in the mediators of nRBC release (erythropoietin versus cytokines) and in disease acuity.

Erythrocyte Aging↗
PubMed1976

The prenatal diagnosis of intrauterine growth retardation in one fetus of a twin gestation.

The prenatal care of twin gestations is primarily concerned with attempts at preventing premature labor and the management of obstetric difficulties. Little data are available prior to delivery, apart from Rh-isoimmunized twin gestations, concerning an individual fetus' well-being in a twin gestation. Ultrasonography has been concerned with the single gestation, and has not been used extensively in the care and evaluation of twin gestations, apart from early diagnosis of the condition. This report involves a twin gestation in which a significant repeated difference in the ultrasonographic fetal biparietal diameter measurements clearly identifies a normal fetus and a fetus with intrauterine growth retardation. The management of this patient could have been more aggressive with the present knowledge available and so resulted in better perinatal outcome.

Adult↗
PubMed1974

Controlled trial of various anti-D dosages in suppression of Rh sensitization following pregnancy. Report to the Medical Research Council by the working party on the use of anti-D-immunoglobulin for the prevention of isoimmunization of Rh-negative women during pregnancy.

In a controlled trial phials containing 200 mug, 100 mug, 50 mug, or 20 mug of IgG anti-D were given to nearly 2,000 D-negative primiparae whose infants were D-positive and ABO-compatible. Only mothers whose serum lacked anti-D were included and the dose of anti-D was always given within 36 hours of delivery. Each phial contained the same total volume of immunoglobulin and the particular dose given to any patient was not known to the clinician. The anti-D content of the phials was estimated three times during the course of the trials and remained fairly constant. Six months after delivery the incidence of a positive indirect antiglobulin test result, indicating the presence of anti-D, in the four dose groups (with about 450 women in each group) was as follows: 0.22%, 0.23%, 0.44%, and 1.35%. The trend towards an increase in the frequency of failures as the dose decreases was significant at the level of P=0.02.In each dose group about 200 women were followed to the end of a second pregnancy with a D-positive infant. The failure rates (in order of decreasing dosage) as judged by a positive indirect antiglobulin test result at the second delivery were as follows: 1.5%, 1.1%, 1.5% and 2.9%. The differences between the dose groups were not statistically significant. The overall failure rate (1.7%) was about one-tenth of that expected in an untreated series. Though the results failed to prove any differences in success rates between doses of 200, 100, 50, and 20 mug of anti-D, they do suggest, in conformity with other evidence, that a dose of 20 mug is suboptimal for routine use. The results support the belief that a dose of 100 mug is adequate.

Adsorption↗
PubMed1989

Intravascular exchange and bolus transfusion in the severely isoimmunized fetus.

Eight Rh-sensitized fetuses, between 21 weeks 2 days and 35 weeks of gestation, received 31 intravascular transfusions (13 exchange and 18 bolus) and one intraperitoneal transfusion under ultrasonographic guidance. The interval between transfusions was 13.4 +/- 4.7 days. Posttransfusion hematocrit dropped at a rate of 1.0% +/- 0.6% per day. Procedure time for the bolus transfusion was shorter than for the exchange transfusion (t test, p less than 0.001). Bleeding from the puncture site complicated 10 of the 31 intravascular transfusions, without apparent maternal or fetal consequences. Fetuses were delivered between 33 and 36 weeks of gestation, after lung maturity was achieved.

Adult↗