SEARCH · PubMed Health

Results for “SCLEROSING SOLUTIONS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 433 records · Page 24Linked to original sources

PubMedDate not supplied

[Treatment of varices in the elderly].

Age is not a contra-indication to the various methods of treatment that may be considered. Only the somatic and vascular assessments of the patient need to be taken into account. Sclerosis can almost always be considered, except when the tissues are obviously unhealthy. It is carried out with weak iodinated solutions or with trombovar. This will give substantial protection from threatening ulcer or rupture of a varix. Surgery is reduced to a minimum, and is followed by supplementary sclerosis. Elastic support is considered in all cases, though it may often be difficult to achieve in arthritic or obese patients. Thermal cures are possible in all cases, though the general contra-indications should be respected (major physiological deficiencies, severe cardiac or renal disease). Phlebotonics will also be prescribed in all cases.

Age Factors↗

PubMed1989

Injection sclerotherapy for spider telangiectasias: a 20-year experience with sodium tetradecyl sulfate.

A 20-year experience using sodium tetradecyl sulfate (Sotradecol, Elkins-Sinn, Inc., Cherry Hill, NJ) for the injection treatment of spider telangiectasias is reviewed. Of 1426 legs injected, 882 were treated with a 1%-solution injected directly into the spider veins, and 264 were injected directly with a 1/3%-solution. With the 1/3%-solution, the remaining 280 legs had the blue veins feeding the spider telangiectasias injected rather than the spider itself. When injected directly into the spider veins, the lesser concentration gave fewer ulcerations and less pigmentation, but equal treatment results. Injecting the subcutaneous feeder veins appears to provide more permanent clearing of the lesions with fewer recurrences and no side effects. No allergic or other major complications occurred with the injection treatments.

Adolescent↗

PubMedDate not supplied

Microparticles prepared by grinding of polymeric films.

Microparticles were prepared by a film grinding method, whereby thin drug-containing ethylcellulose films were cryogenically ground into microparticles. The particle size and shape of the microparticles could be controlled by the thickness of the films and by the milling time. The encapsulation efficiency as well as the in vitro drug release depended on the physical state of the drug in the ethylcellulose matrix (dispersed vs dissolved). Increased drug loadings and decreased particle size and film thickness increased the drug release. Microparticles prepared from cast films were more dense and had a slower drug release compared to microparticles prepared from sprayed films or from films prepared from an aqueous colloidal ethylcellulose dispersion, Aquacoat ECD. Lamination of the drug-containing film with a drug-free polymer layer on both sides resulted in a reduced drug release. Hydrophilic plasticizers acted as pore-formers and accelerated drug release, while lipophilic plasticizers reduced the drug release. The solubility of the drug in the organic polymer solution was one of the main parameters to achieve high encapsulation efficiencies and extended drug release, while dispersed drug was released much faster. The drug release from microparticles prepared by film grinding was faster than from microparticles prepared by the solvent evaporation method. The faster release was attributed to the fractured surface of the ground particles. Grinding of microparticles, which were prepared by the solvent evaporation, also resulted in a faster release.

Biocompatible Materials↗

PubMed1995

Is endoscopic injection hemostasis of bleeding gastrointestinal ulcers obsolete in 1995?

Bleeding non-neoplastic lesions of the upper gastrointestinal tract, not due to portal hypertension, are a frequent cause of emergency admission. In the present paper we report our retrospective experience in hemostatic injection treatment of these lesions. From May 1990 to May 1994, 164 patients were admitted to our institution for a bleeding gastrointestinal lesion. In 124 cases an ulcer classified according Forrest's criteria was detected. Four patients underwent immediate surgery. The second group of 86 patients (FIIa/FIIb/FIII) were treated conservatively. The third group of 34 patients (FIa/FIb/FIIa) underwent perilesional injection of adrenaline 1:10,000 and polidocanol 1% saline solution during endoscopic examination; 29% (25 pts) of the second group re-bled during the first 72 h vs 8.8% (3 pts) of the third group. The postoperative morbidity in the rebleeding patients was higher in the second group: 38.4% vs 0%. The importance of immediate, inexpensive, and simple hemostatic treatment extended to Forrest IIa lesions is emphasized.

Adolescent↗

PubMed1990

[Endoscopic injection therapy in acute non-varicose upper gastrointestinal hemorrhage].

Emergency esophago-gastro-duodenoscopy was performed in 45 consecutive patients (26 men, 19 women, mean age 64 [23-91] years) with non-varicose upper gastrointestinal bleeding. The bleeding was arrested endoscopically by circumferential injection of an average of 6 (2-10) ml 1% polidocanol solution. In 10 patients an injection treatment was not possible because of extensive erosion or massive arterial bleeding. Bleeding recurred in seven patients 12-48 hours after initial injection. One patient in whom injection was not possible died during operation from massive intractable bleeding from an aortoduodenal fistula after abdominal aorta aneurysm surgery with implantation of a dacron prosthesis. There were no complications of the injection treatment.

Adult↗

PubMed1996

Treatment of vulvar varicosities by injection-compression sclerotherapy and a pelvic supporter.

Injection of vulvar varicosities with a 1% solution of sodium tetradecyl sulfate and subsequent compression therapy with a pelvic supporter was used to treat five women with symptoms of vaginal pressure, swelling, and pain. Three patients were premenstrual, and the two others were approximately 8 weeks post-vaginal delivery. Physical examination was performed in the upright as well as the dorsal lithotomy positions, and injection was given in the supine position. All patients noticed marked improvement in symptoms after treatment. We conclude that this technique has potential as a simple, effective way to treat symptomatic vulvar varicosities.

Adult↗

PubMed1997

Treatment of vulvar varicosities by injection-compression sclerotherapy.

BACKGROUND: Techniques of injection-compression sclerotherapy of lower extremity varicosities can be applied to treat patients with symptomatic vulvar varicosities. OBJECTIVE: To effectively use injection-compression sclerotherapy to treat patients with symptomatic vulvar varicosities. METHODS: Injection of vulvar varicosities with a 1% solution of sodium tetradecyl sulfate and subsequent compression therapy with the V2-Supporter was used to treat seven patients with symptoms of vaginal pressure, swelling, and pain. RESULTS: Three of the seven patients were premenstrual and four others were approximately 8 weeks post-vaginal delivery. Physical examination was performed in the upright as well as the dorsal lithotomy positions and injection was administered in the supine position. All patients noticed marked improvement in symptoms after treatment. CONCLUSION: We conclude that this technique has potential as a simple, effective way to treat symptomatic vulvar varicosities.

Adult↗

PubMed1989

[Varicocele: the effects of sclerotherapy on hemodynamics and spermatogenesis].

Between January 1984 and July 1988, percutaneous retrograde sclerotherapy of varicocele was successfully performed on 267 patients. A 5% solution of sodium morrhuate and benzylic alcohol (Varicocid) was administered through a coaxial balloon catheter inserted into the spermatic vein. Nine of the patients had relapses after surgery. Long-term follow up was available for 248 patients. Three of them had incomplete relapses after sclerotherapy. In terms of spermatologic improvement, sclerotherapy appeared to be effective in the treatment of varicoceles. In our experience, sclerotherapy is a safe and effective procedure to be preferred to surgery in the management of varicocele.

Adolescent↗

PubMed2002

Persistent paraplegia after an aqueous 7.5% phenol solution to the anterior motor root for intercostal neurolysis: a case report.

A 55-year-old white man with severe scoliosis and chest deformity was scheduled for an intercostal neurolysis for pain relief with 7.5% aqueous phenol solution. A 20 G needle was inserted 3 to 4cm lateral to the midline of the spine under the 10th right rib. After negative aspiration for blood and alcohol, 6mL of a 7.5% aqueous phenol solution was injected. Within a minute after the injection, the patient felt a warm sensation in his right leg, followed by loss of leg motor and sensory function on both sides. A lumbar puncture done 3.5 hours after the block showed a phenol concentration of 87.5 microg/mL. The most likely explanation is a diffusion of the phenol through the intervertebral foraminae reaching the spinal space and therefore damaging the motor and sensory roots. This case highlights the danger associated with phenol application in the vicinity of the spinal cord.

Humans↗

PubMed1991

[Tetracycline sclerotherapy of hydroceles and spermatoceles].

40 patients were treated by aspiration and instillation of a 10% solution of tetracycline. 32 were cured after average 1.45 instillations. The dominating adverse effect was scrotal pain, reported by 55% of the patients. One patient experienced a transient vasovagal reaction due to the pain, and one patient was suspected of having a slight infection. No other adverse effect was registered, and 90% of the patients would prefer to have the same treatment rather than an operation if another treatment were found necessary. The treatment is given as an outpatient procedure at 1/10 of the cost of traditional operative treatment, and with comparable results.

Adult↗

PubMed1993

Successes and failures of endoscopic injection haemostasis for bleeding peptic ulcers. A prospective clinical study.

Fifty-two consecutive patients with upper gastrointestinal haemorrhage, shock (systolic blood pressure less than 100 mmHg) and a peptic ulcer showing endoscopic stigma of recent haemorrhage underwent attempts at endoscopic haemostasis. The ulcers were injected with a dilute solution of adrenaline followed by 5% ethanolamine oleate. Active bleeding was present in 22 patients (42%) at initial endoscopy. Bleeding was controlled in 40 patients (77%) in hospital. Failure occurred more frequently in duodenal ulcers than gastric ulcers (46% v. 7%; P < 0.004), and in giant (more than 2 cm diameter) duodenal ulcers (6/7) than smaller duodenal ulcers (3/15). We recommend early surgery for large posterior duodenal ulcers in preference to endoscopic injection methods.

Adult↗

PubMed2001

Removal of periocular veins by sclerotherapy.

PURPOSE: Prominent periocular veins, especially of the lower eyelid, are not uncommon and patients often seek their removal. Sclerotherapy is a procedure that has been successfully used to permanently remove varicose and telangiectatic veins of the lower extremity and less frequently at other sites. Although it has been successfully used to remove dilated facial veins, it is seldom performed and often not recommended in the periocular region for fear of complications occurring in adjacent structures. The purpose of this study was to determine whether sclerotherapy could safely and effectively eradicate prominent periocular veins. DESIGN: Noncomparative case series. PARTICIPANTS: Fifty adult female patients with prominent periocular veins in the lower eyelid were treated unilaterally. PATIENTS AND METHODS: Sclerotherapy was performed with a 0.75% solution of sodium tetradecyl sulfate. All patients were followed for at least 12 months after treatment. MAIN OUTCOME MEASURES: Complete clinical disappearance of the treated vein was the criterion for success. RESULTS: All 50 patients were successfully treated with uneventful resorption of their ectatic periocular veins. No patient required a second treatment and there was no evidence of treatment failure at 12 months. No new veins developed at the treated sites and no patient experienced any ophthalmologic or neurologic side effects or complications. CONCLUSIONS: Sclerotherapy appears to be a safe and effective means of permanently eradicating periocular veins.

Adult↗

PubMed2000

Histopathological examination of chemo-sympathectomy in cats.

In recent decades, there has been an increase in both the number of sympathectomy techniques, as well as the surgical findings of sympathetic anatomy. Currently the advanced technique of C-arm guided percutaneous thoracic chemo-sympathectomy is widely used for the treatment of palmar hyperhidrosis. However, a better understanding of chemical agents in sympathectomy is required. In this study, chemo-sympathectomy was performed in cats, using alcohol, glycerol and various concentrations of phenol, to determine the chronic neurotoxic effects of these chemical agents on the stellate ganglia. The stellate ganglia of 24 cats were exposed under endotracheal general anesthesia, then injected with about 0.02 ml of absolute alcohol, glycerol and phenol (10%, 25%, 50%, and 75% concentration) solutions, respectively. The stellate ganglia were taken for histological examination three weeks after the chemical injection. The results showed that the degenerative changes in the cytoplasm and nucleus of ganglionic cells and intercellular tissue were moderate and relatively moderate after the injection of alcohol and glycerol, respectively. Meanwhile, the stellate ganglia revealed mild, relatively moderate, serious and extremely serious degeneration after injection of 10%, 25%, 50%, and 75% phenol, respectively. In conclusion, we recommend a high concentration of phenol, in the least volume, as a chemical agent for clinical injection in the upper thoracic sympathetic ganglion.

Animals↗

PubMed2000

Topical application of docosanol- or stearic acid-containing creams reduces severity of phenol burn wounds in mice.

Because of their reported antiviral and anti-inflammatory activities, cream formulations containing n-docosanol (docosanol) or stearic acid were tested for effects on chemically-induced burns in mice. In this model, injury was induced by painting the abdomens of mice with a chloroform solution of phenol. This was followed by the topical application of test substances 0.5, 3, and 6 h later. Progression of the wounds was assessed by a single evaluator after 8 h, using a numerical score of gross morphology. Docosanol- and stearic acid-containing creams substantially and reproducibly lessened the severity and progression of skin lesions compared to untreated sites with a 76% and 57% reduction in mean lesion scores, respectively. Untreated wounds appeared red and ulcerated; docosanol cream-treated wounds showed only slight erythema.

Animals↗

PubMedDate not supplied

Local phenol injection in the treatment of interdigital neuritis of the foot (Morton's neuroma).

The symptomatic treatment of Civinini-Morton syndrome (interdigital neuritis: IDN) may be performed directly on the nervous trunk involved using orthotic, local pharmacological or surgical methods. Alcoholization with phenol in the percutaneous treatment of IDN has the purpose of provoking a permanent chemical neurolysis, obtaining remission of the neuritic pain symptoms. A total of 71 cases were treated by a dorsal approach to the intermetatarsal space using a needle-electrode connected to the electro-stimulator. Once the nervous trunk with a reproduction of the paresthesia to the fingers was localized, 2.5 ml of phenol at 5% water solution was injected, immediately followed by local anesthetic with a postsurgical analgesic purpose. Mean follow-up was 36 +/- 8 months. The patients were evaluated by visual analogue scale for pain (VAS). Alcoholization of the common interdigital nerve proved to be effective in treating pain in 80.3% of cases (57/71). Treatment must be considered a percutaneous mini-invasive surgical procedure. The results are better than those reported in the literature with conservative and infiltrative treatment and they appear to be comparable today with those obtained when surgical treatment was used, with no complications occurring.

Adult↗

PubMed1994

[Treatment of hydrocele with evacuation and percutaneous sclerosis with polidocanol].

Twenty male patients aged 26-79 years old, with symptomatic unilateral hydrocele, were treated by evacuation puncture and intracavitary instillation of 2 ml of a 3% polydocanol solution. In 13 cases, treatment was done ambulatory and only in the first few cases sperm cord anaesthetics was used. Regular follow-up of at least 6 months was made. No complications were encountered and only one third of patients complained of mild pain. In 12 cases (60%) hydrocele cure was achieved and 6 relapsed (another 2 were lost to follow-up). Testes ultrasound performed 1 month later showed that 4 patients had non-symptomatic multicystic relapse, which disappeared spontaneously within 6 months in three cases. The advantages of this substance in hydrocele non-surgical treatment versus other therapies used until now are reviewed, concluding by recommending other groups to test it clinically.

Adult↗

PubMed1987

Postsclerotherapy hyperpigmentation: a histologic evaluation.

Linear or macular pigmentation occurs in 10-30% of patients following sclerotherapy of vessels between 0.1 and 5 mm in diameter. Its occurrence is related to solution strength, vessel fragility, injection pressure, and the type of solution used. This adverse sequela of treatment has been assumed, by some, to represent post-inflammatory hyperpigmentation (incontinence of melanin pigment), and has been said to occur in individuals with this tendency. Histologic data presented in this paper suggest that this phenomenon does not represent melanocytic alteration, but is secondary to extravasation of red blood cells into the dermis following rupture of fragile vessels with resulting deposition of hemosiderin. Therapy has included bleaching agents (hydroquinones), trichloroacetic acid, and phenolic peeling agents with variable success. Eighty percent of patients who experience this adverse sequela will clear spontaneously within 6-24 months. The remaining patients will have persistence of pigmentation for up to 5 years, with a small number of patients having pigmentation persisting 5 years after therapy.

Biopsy↗

PubMed1989

Phenol sclerotherapy for hydrocele: a study in 55 patients.

Sclerotherapy with 2.5% phenol solution was used to treat 63 hydroceles in 55 patients with a mean age of 69 years. In 51.6% of the patients (32 hydroceles) 1 treatment was sufficient, while 2 treatments were necessary in 25.8% (16 hydroceles), 3 in 13% (8 hydroceles) and 4 in 8% (5 hydroceles). One patient required 7 injections. Treatment was unsuccessful in 1 patient in whom a local allergic reaction developed. Only 1 patient complained of pain, and other complications were rare and mild. On the basis of this experience we concluded that sclerotherapy with phenol 2.5% is a painless, highly effective, safe and economical procedure that permits one to avoid an operation, anesthesia and hospitalization. Its use is warranted in adults and particularly in the elderly.

Adult↗