PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Zinc Compounds”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 433 records · Page 24Linked to original sources

Synthesis and characterization of metal selenide (ZnSe, CdSe, HgSe) nanoparticles.

Thermolysis of [M(SeCH2CH2CH2NMe2)2] (M = Zn, Cd, Hg), prepared by the reactions of sodium salt of 3-(N,N-dimethylamino)propaneselenolate with metal acetates, afforded metal selenides (MSe). The metal selenides were characterized by XRD, EDAX, SEM, AFM, and TEM techniques. Nanoparticles of HgSe were prepared by pyrolysis in a quartz boat, solvothermal, and sonochemical methods. EDAX showed 1:1 Hg/Se ratio, while XRD and SAED patterns confirmed the formation of cubic HgSe. These particles are spherical in nature with an average diameter of 15 nm (from TEM).

Cadmium Compounds↗

In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide.

We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.

Animals↗

The effects of dentifrice systems on oral malodor.

Chronic oral malodor is a serious concern for about one-fifth of the North American population, and a field of emerging research interest. The present three studies, one involving gas chromatography and two employing odor judge assessment, examined the efficacy of baking soda and other toothpastes in reducing breath odor. The most common cause of oral malodor is elevated levels of volatile sulfur compounds (VSC's), primarily hydrogen sulfide (H2S) and methyl mercaptan (CH3SH), in the breath. Gas chromatography, an accurate means of measuring breath VSC, was employed to evaluate the breath levels of VSC in 11 men after brushing with baking soda-containing dentifrices with or without the addition of Zn++. Dentifrices with either Zn++ or a concentration of baking soda 20% or greater significantly reduced VSC levels. The addition of Zn++ to baking soda dentifrices enhanced the anti-odor effects. In the first organoleptic study, dentifrices containing 20% baking soda and 30% baking soda demonstrated significantly greater ability to reduce breath odor than a standard sodium fluoride/silica dentifrice. The subjects' baseline mouth odor evaluations, initially rated as strong, declined after brushing with the baking soda toothpastes to a barely detectable level at one hour, then rising to a faint level at two hours and moderate levels at three hours. In the second organoleptic study, a dentifrice containing 65% baking soda demonstrated significantly greater ability to reduce breath odor than a standard sodium fluoride/silica tartar control dentifrice, but did not differ significantly from a standard dentifrice containing 0.76% sodium monofluorophosphate in a dicalcium phosphate dihydrate base. The results of these studies indicate that dentifrices containing 20% or more baking soda can confer a significant odor-reducing benefit for time periods up to three hours.

Adult↗

[A case of polaprezinc-induced pneumonitis].

A 77-year-old man referred to our hospital three months ago presented with dyspnea on effort and chest radiograph abnormalities. Chest computed tomography showed consolidation and irregular thickening of the peribronchovascular interstitium. Bronchoalveolar lavage fluids showed increases in the percentage of lymphocytes and a decrease of the CD4/8 ratio. Transbronchial lung biopsy specimens showed signs of organizing pneumonia. The patient had been given polaprezinc for the treatment of hypogeusia six months before. A lymphocyte-stimulating test for polaprezinc was positive, and so our diagnosis was polaprezinc-induced pneumonitis.

Aged↗

[Trace elements and endemic goiter].

The effects of xenobiotics on morphological structure and function of the thyroid gland (TG) were analysed. Salts of heavy metals (zink, lead, copper, cadmium, surma etc.) were measured in TG of 152 citizens of Kama region who had died of trauma in the 1960s (n = 73), 1990s (n = 20) and 2000s (n = 52). TG is shown to accumulate xenobiotics. As the examinees had no occupational contact with heavy metal salts (HMS), their deposits in TG is explained by anthropogenic pollution of the environment. HMS in the thyroid tissue was much lower than in later decades indicating aggravation of environmental pollution in the Urals. Being protoplasmic poisons, HMS bind proteins and provoke immune reaction. All the examinees who died after 2000 had histologically proved deposits of immunocompetent cells in TG tissue--lymphoid and plasmic TG infiltration. In the 1960s these TG alterations were absent. Goiter endemia can be stopped by improvement of environmental protection in each ecopolluted region and mass iodine prophylaxis.

Adult↗

Photodynamic therapy in general surgery.

Authors' experience in detecting neoplasms by a computerized telethermographic system in animal models is reported. The new technique seems to have a great potential as a photo-diagnostic method particularly when followed by the surgical treatment or the photodynamic therapy (PDT) of the neoplastic lesions. Literature reports on the PDT of tumors are reviewed.

Animals↗

A self-assembled pigmented BLM on a platinum support: the light-induced electrical effects.

The light-induced voltage and current changes under continuous illumination have been investigated in pigmented self-assembled lipid bilayer membranes deposited on a platinum electrode. Such self-organized pigmented bilayer-platinum system containing Zn-Phthalocyanine (ZnPc) as a photosensitizer and glycerol-dioleate (GDO) as a bilayer forming solution has been found to shift its electrode potential to more positive value on light irradiation as well as to increase the cathodic current across the membrane. The results indicate a direct electron transfer from the platinum electrode to hydrogen ion in the electrolyte solution. Furthermore, it has also been demonstrated a dramatic increase of the photocurrent over the time course of BLM formation visualizing a role of the bulk quenching processes which are significantly diminished in thin bilayer membrane.

Diglycerides↗

[Carbostimulin-correcting effect on metabolic aspects of diabetes mellitus].

Application of carbostimulin, the preparation stimulating CO2 fixation in tissues, in a complex therapy of diabetes mellitus patients rises the CO2 level, restores the total content of alpha-ketoacids and free amino acids in blood, increases (within the physiological normal limits) the urea content in blood and urine of diabetes mellitus patients.

Amino Acids↗

Butane-1,4-diamine zinc(II) hydrogen phosphite.

The title compound, poly[zinc(II)-mu-butane-1,4-diamine-mu-(hydrogen phosphito)] (C(4)H(12)N(2))(0.5)[ZnHPO(3)], is a hybrid organic-inorganic solid built up from 1,4-diaminobutane molecules, Zn(2+) cations (coordinated by three O atoms and one N atom) and HPO(3)(2-) hydrogen phosphite groups. The organic species bonds to the Zn atom as an unprotonated ligand, resulting in it acting as a bridge between infinite ZnHPO(3) layers, which propagate in (100). The complete butane-1,4-diamine species is generated from a H(2)N(CH(2))(2)- half molecule by inversion symmetry. The zincophosphite sheets contain polyhedral four- and eight-membered rings in a 4.8(2) topology.

Journal Article↗

In-situ evaluation of barrier-cream performance on human skin using laser-induced breakdown spectroscopy.

Laser-induced breakdown spectroscopy (LIBS) was used to evaluate the effect of barrier creams (skin protective creams) on human skin. A Nd: YAG laser at 1,064 nm was used with a pulse energy of 100 mJ. A method was developed to measure the effectiveness of barrier creams against zinc ion absorption from aqueous zinc chloride solution and oil paste zinc oxide, which represent model hydrophilic and lipophilic metal compounds, respectively. Zinc was chosen since it posed no risk to human skin. 3 representative commercial barrier creams advertised as being effective against lipophilic and hydrophilic substances were evaluated by measuring zinc absorbed through the stratum corneum. 4 consecutive skin surface biopsies (SSB) were taken from biceps of the forearms of 6 volunteers at time periods of 0.5 h and 3 h after application of the protective cream. Results were compared with control skin where no barrier cream was used. The zinc atomic emission line at 213.9 nm was selected. Gate delay and gate width time was optimized to obtain the best signal-to-noise ratio (SNR) and precision. This method provided a facile and rapid screening of the effectiveness of skin barrier creams against zinc ion penetration. The barrier creams were shown to provide appreciable protection against the penetration of both ZnCl2 and ZnO into the skin.

Adult↗

Suppression of retrovirial replication: inactivation of murine leukemia virus by compounds reacting with the zinc finger in the viral nucleocapsid protein.

All retroviral nucleocapsid (NC) proteins, except those of spumaretroviruses, contain one or two zinc fingers, consisting of the sequence C-X2-C-X4-H-X4-C. Rice et al. (Science 270:1194-1197, 1995) have described a series of compounds which inactivate HIV-1 particles and oxidize the sulfur atoms in the NC zinc finger. We have characterized the effects of three such compounds on Moloney murine leukemia virus (MuLV). We find that, as with HIV-1, the compounds inactivate cell-free MuLV particles and induce disulfide cross-linking of NC in these particles. In contrast, the compounds have no effect on the infectivity of human foamy virus, a spumaretrovirus lacking zinc fingers in its NC protein. The resistance of foamy virus supports the hypothesis that the zinc fingers are the targets for inactivation of MuLV and HIV-1 by the compounds. The absolute conservation of the zinc finger motif among oncoretroviruses and lentiviruses, and the lethality of all known mutations altering the zinc-binding residues, suggest that only the normal, wild-type structure can efficiently perform all of its functions. This possibility would make the zinc finger an ideal target for antiretroviral agents.

Amino Acid Sequence↗

Transition metal salt solutions and anaerobic adhesives in dental bonding.

OBJECTIVES: The objectives of this experiment were twofold. Firstly to determine whether an anaerobic adhesive could be used to bond steel attachments to etched human enamel, following treatment of this surface with various concentrations of copper (II) sulphate solution. Secondly, to determine the effect of 0.05 M solutions of other transition metal sulphates and chlorides on the same bonding process. METHODS: Stainless steel attachments were bonded to human enamel using an anaerobic adhesive. In each case the enamel, which had been ground flat, was etched with 37% o-phosphoric acid and then treated with copper (II) sulphate solution prior to bonding. After bench curing for one hour, the specimens were shear tested to failure, and the load at bebond recorded in each case. The effect of varying the concentration of copper (II) sulphate solution was determined. Following determination of the optimal copper (II) sulphate concentration, the experiment was repeated using the same concentration of various other transition metal sulphates and chlorides. RESULTS: The results were analysed using mean force to debond (N) and 95% confidence intervals. Kaplan-Meier survival probabilities and log-rank tests were also performed. CONCLUSIONS: Under the conditions of this experiment the optimal concentration of copper (II) sulphate solution was found to be 0.05 M. Of the various transition metal sulphates and chlorides under test, the sulphates appeared to provide a more active surface for the polymerisation of the anaerobic adhesive than the chlorides. Of the sulphate solutions, the most effective was that of copper. SIGNIFICANCE: Anaerobic adhesives show promise as dental bonding agents capable of bonding metal attachments to enamel following enamel pretreatment with 0.05 M copper (II) sulphate solution.

Adhesives↗

Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro.

BACKGROUND: Polaprezinc has been shown to exert an anti-oxidant property in a tube experiment, protect gastric mucosa from experimental ulcerations in vivo, and accelerate the healing of gastric ulcer in humans. AIM: To examine a possible protective effect of polaprezinc on oxidant-mediated injury in primary monolayer cultures of rat gastric fundic mucosa. METHODS: Cytotoxicity was quantified by measuring 51Cr release. Whether or not polaprezinc exerts an antioxidant property was investigated by determining the effect of this agent on hydrogen peroxide (H2O2)-induced injury. The effects of polaprezinc on superoxide (O2-. ) generation as well as on ethanol (EtOH)-induced injury were also examined. Generation of O2-. was assessed by the reduction in cytochrome c. RESULTS: H2O2 caused a time- and dose-dependent increase in 51Cr release. The dose-response curve of 51Cr release by H2O2 shifted to the right in the presence of polaprezinc. Polaprezinc, at submillimolar concentrations, prevented H2O2-induced 51Cr release. EtOH also caused a dose-dependent increase in 51Cr release, which was prevented by the addition of polaprezinc. The incubation of cells with EtOH caused an increase in cytochrome c reduction, as the concentrations of EtOH increased. Polaprezinc inhibited EtOH-induced cytochrome c reduction. Protection by polaprezinc was microscopically associated with the prevention of monolayer disruption. CONCLUSIONS: Polaprezinc is antioxidative and directly protects gastric mucosal cells from noxious agents through its antioxidant properties in vitro. This finding may provide the theoretical basis for the usage of an antiulcer drug with antioxidant properties for the treatment of gastric inflammation, such as that induced by ethanol.

Animals↗