[Effect of psychotropic agents in emotional stress].
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Chronic tests on cats showed that diazepam and nitrazepam lower the amplitude of primary responses (PR) of the second somatosensory zone of the brain cortex both to a single and paired stimulation of the thalamo-cortical radiation of fibers. Meprotan, while potentiating the PR to a single stimulation, does not influence the course of the PR restitution cycles. Benacryzine, while enhancing the PR to a single stimulation, produces the appearance of a lengthy phase of depression throughout the PR restitution cycle. In acute tests with unanesthetized, flaxedil immobilized cats, with an isolated cortical band underneath a stimulating electrode, analogous changes in PR both to a single and paired stimulation of the thalamo-cortical radiation of fibers were noted.
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The results of investigations into the effect of microinjections of a number of adrenocholino- and dophaminergic agents on excitability of the pale globe, caudate nucleus and shell are reported. The non-uniformity of the effects produced by the agents of the mediator type action is established both in different segments and in individual zones of the extrapyramidal system with continuous concurrent antagonism between the mimetics and the corresponding blocking agents. The presence of alpha- and beta-adrenoreceptors and also of M- and N-cholinoreceptors in the structures of the striopallidal complex is suggested.
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