[Changes in alkaline phosphatase activity in blood during hormonal treatment of metastasized mammary cancer].
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Under examination were 186 patients with diseases of the liver and biliary ducts. In patients with mechanical jaundice resulting from cholelythic disease high indices of the activity of 5-nucleotidase and alkaline phosphatase were revealed in 80--85% of cases, in patients with carcinoma of the head of the pancreas--in 100%. The investigation of these tests and blood serum transaminases in dynamics is of great importance for differential diagnosis of diseases of the liver and biliary ducts manifesting themselves by the jaundice syndrome.
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Human neutrophils were isolated from cord blood drawn after Caesarean section deliveries without labour and from peripheral blood from healthy adults. The alkaline phosphatase (ALP) activity in the cell populations was compared with the release of respiratory burst products after activation with the chemoattractant n-formyl-methionyl-leucyl-phenylalanine (fMLP). In contrast to cord blood neutrophils obtained from babies after normal vaginal deliveries, the Caesarean section neutrophils were not metabolically primed. However, like the neutrophils from vaginally delivered babies, the Caesarean section neutrophils showed an increased ALP activity compared to adult control neutrophils. These findings indicate that priming of cord blood neutrophils appears to be induced by labour and can be dissociated from increased ALP activity.
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