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PubMed1988

Vegetarian dietary practices and endurance performance.

Confounding influences of varying fat, protein, and carbohydrate (CHO) levels, training habits, and lifestyle patterns make the interpretation of specific influences of the diet on endurance performance unclear. In general, exhaustion during prolonged, hard endurance exercise is tied to low muscle glycogen stores. Athletes in heavy training are urged to consume 70% of calories as CHO to maximize body CHO stores. A deemphasis in animal products with an emphasis in high-CHO plant foods would facilitate athletes in conforming to nutritional recommendations. Some female athletes may increase their risk of iron deficiency and/or amenorrhea if a restrictive vegetarian diet is adopted. In general, the high-CHO nature of the vegetarian diet can help the endurance athlete in heavy training maximize body glycogen stores and thus the ability to perform. The balanced vegetarian diet provides the athlete with added reduction in coronary risk factors while meeting all known nutritional needs.

Diet↗

PubMed2004

Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin.

Acute renal failure secondary to ischemic injury remains a common problem, with limited and unsatisfactory therapeutic options. Neutrophil gelatinase-associated lipocalin (NGAL) was recently shown to be one of the maximally induced genes early in the postischemic kidney. In this study, the role of NGAL in ischemic renal injury was explored. Intravenous administration of purified recombinant NGAL in mice resulted in a rapid uptake of the protein predominantly by proximal tubule cells. In an established murine model of renal ischemia-reperfusion injury, intravenous NGAL administered before, during, or after ischemia resulted in marked amelioration of the morphologic and functional consequences, as evidenced by a significant decrease in the histopathologic damage to tubules and in serum creatinine measurements. NGAL-treated animals also displayed a reduction in the number of apoptotic tubule cells and an increase in proliferating proximal tubule cells after ischemic injury. The results indicate that NGAL may represent a novel therapeutic intervention in ischemic acute renal failure, based at least in part on its ability to tilt the balance of tubule cell fate toward survival.

Acute Kidney Injury↗

PubMed1976

The rectal complex in the larvae of lepidoptera.

In the so-called "cryptonephric" condition of the excretory system in insects the distal ends of the Malpighian tubules are closely applied to the rectum and enclosed with it in a special chamber, the perinephric space, separated from the rest of the body cavity by the perinephric membrane. The term "rectal complex" refers to this association of tubules and rectum, which is found in the larvae (but not in the adults) of most Lepidoptera. In the mealworm (Coleoptera) the rectal complex has notable ability to remove water from the faeces, but this ability is not conspicuously developed in the larvae of the two species of Lepidoptera here studied: Pieris brassicae and Manduca sexta. On the other hand these larvae have notable ability to maintain salt balance under heavy dietary loading, and in this the rectal complex plays an important part. A study of salt balance in more detail has shown that more sodium can be eliminated in the faeces than enters the rectal complex from the intestine. Consideration of other possible routes of entry points strongly to the Malpighian tubules. Superimposed upon a new flow of tubule fluid out of the rectal complex there is a tidal flow, brought about by the rectal musculature and amplified by dilatations of the cryptonephric tubules, which could bring in fluid from the free tubules and afford opportunity for the uptake of salts. Evidence is presented in support of this view. This tidal flow of tubule fluid and uptake of salts could be the basis of the build-up of high osmolarity in the perinephric fluid and could contribute to the removal of water from the faeces. It could also be the basic mechanism in the mealworm, the leptophragmal mechanism being superimposed upon it.

Animals↗

PubMed1990

Cold-induced lipid phase transitions.

The structural organization of biological membranes is largely determined by the weak interactions existing between their components and between these components and their aqueous environment. These interactions are particularly sensitive to changes in temperature and hydration. The factors influencing membrane lipid phase behaviour are briefly reviewed and used to develop a phase-separation model describing the response of biological membranes to stress. The factors affecting the interaction of cryoprotectants with membrane lipids are explored and their role in the stabilization of membrane organization at low temperatures discussed. It is suggested that the basis of their protective action lies in an ability to preserve the balance of interactions between membrane components at low temperatures at a level similar to that existing under physiological conditions.

Cold Temperature↗

PubMed1996

The role of nephrectomy and proadifen in blood pressure homeostasis following an acute kinin-induced hypotension in normotensive rats.

1. We have, in the present work, studied the importance of the kidneys and the renal hypotensive agent, medullipin, in modulating the blood pressure (BP) response to bradykinin, as well as their ability to influence the balance between the NO- and the adrenergic systems superimposed on a bradykinin-induced hypotension. 2. The rats were pretreated with the NO-synthase inhibitor, N omega-nitro-L-arginine methyl esther (L-NAME) (0.3 g kg-1), proadifen (50 mg kg-1), an inhibitor of the medullipin-system, and nephrectomy (24 h) (Nx) alone, and L-NAME in combination with proadifen, Nx or phentolamine (2 mg kg-1). Subsequent injections of bradykinin (3, 6, 15, 30 micrograms kg-1) induced an acute hypotensive response. The fall in BP was dose-dependent in all groups (P < 0.01), except in the Nx/L-NAME group. No differences in the fall in BP were observed between the groups. 3. The duration of the hypotensive response was abbreviated after L-NAME-treatment (P < 0.05). Proadifen-treatment and Nx had no significant effect on the duration of the hypotension in control rats or in L-NAME-treated rats. Pretreatment with phentolamine prevented the L-NAME-induced rapid restoration of BP (P < 0.001). 4. In L-NAME-treated rats a transient hypertension followed the bradykinin-induced hypotensive response. This hypertensive response was not observed after Nx or proadifen-treatment alone, and addition of Nx or proadifen to L-NAME treatment did not alter the hypertensive response as compared to L-NAME alone. Phentolamine, however, abolished the L-NAME-induced hypertension (P < 0.05). 5. In conclusion, the present results do not support the involvement of the medullipin-system or other hypotensive systems localized in the kidneys, in modulating and counteracting the compensatory adrenergic response following an acute bradykinin-induced hypotension. A hampering modulating effect of the NO-system on this compensatory adrenergic response was confirmed, indicating a close relationship between these two systems in BP homeostasis.

Animals↗

PubMed2002

Importance of increased ultrafiltration volume and impact on mortality: sepsis and cytokine story and the role for CVVH.

There is growing interest in extracorporeal blood purification therapies (EBPT) as adjuvants in the complex therapy of sepsis and multiple organ dysfunction syndrome (MODS). Nowadays the only routinely used purification technique is 'renal replacement therapy' (RRT) during acute renal failure (ARF), one of the almost inevitable and deadly components of MODS. RRT has been the first and still is the most utilised and effective type of EBPT. Evidence is growing about its ability to maintain homeostatic balance in critically ill patients, and specifically in septic patients with MODS. Clinical trials have been recently designed to modify or improve these therapies. In detail, the following issues have been currently addressed: effects on blood purification provided by different therapies, adequacy of prescription and delivery of therapy, toxins and solutes to be removed with these techniques. Based on these speculations we will briefly review the current understanding of these issues and the rationale for application of RRT in the intensive care unit (ICU). In particular, we will focus on the importance of increased ultrafiltration volume and its impact on mortality in the general ICU population and in septic patients.

Acute Kidney Injury↗

PubMed1982

Undergraduate teaching in geriatric dentistry.

It is predicted that more Australians will retain their natural dentitions into old age and their dental needs will have to be met with a wide range of dental services by dentists acting with understanding, kindness, and sympathy. The empathy to do so requires experience of appropriate delivery systems in the environment in which the elderly live. For them the ability to eat a balanced and varied diet and to manage personal oral hygiene is very important for their well being. Undergraduate education must be adapted to strengthen the social orientation demanded.

Aged↗

PubMed1986

Symmetry in running.

Symmetry plays a key role in simplifying the control of legged robots and in giving them the ability to run and balance. The symmetries studied describe motion of the body and legs in terms of even and odd functions of time. A legged system running with these symmetries travels with a fixed forward speed and a stable upright posture. The symmetries used for controlling legged robots may help in elucidating the legged behavior of animals. Measurements of running in the cat and human show that the feet and body sometimes move as predicted by the even and odd symmetry functions.

Animals↗

PubMed2002

Pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate in humans.

The pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) (liposomal AMB) and the conventional formulation, AMB deoxycholate (AMB-DOC), were compared in a phase IV, open-label, parallel study in healthy volunteers. After a single 2-h infusion of 2 mg of liposomal AMB/kg of body weight or 0.6 mg of AMB-DOC/kg, plasma, urine, and feces were collected for 168 h. The concentrations of AMB were determined by liquid chromatography tandem mass spectrometry (plasma, urine, feces) or high-performance liquid chromatography (HPLC) (plasma). Infusion-related side effects similar to those reported in patients, including nausea and back pain, were observed in both groups. Both formulations had triphasic plasma profiles with long terminal half-lives (liposomal AMB, 152 +/- 116 h; AMB-DOC, 127 +/- 30 h), but plasma concentrations were higher (P < 0.01) after administration of liposomal AMB (maximum concentration of drug in serum [C(max)], 22.9 +/- 10 microg/ml) than those of AMB-DOC (Cmax, 1.4 +/- 0.2 microg/ml). Liposomal AMB had a central compartment volume close to that of plasma (50 +/- 19 ml/kg) and a volume of distribution at steady state (Vss) (774 +/- 550 ml/kg) smaller than the Vss of AMB-DOC (1,807 +/- 239 ml/kg) (P < 0.01). Total clearances were similar (approximately 10 ml hr(-1) kg(-1)), but renal and fecal clearances of liposomal AMB were 10-fold lower than those of AMB-DOC (P < 0.01). Two-thirds of the AMB-DOC was excreted unchanged in the urine (20.6%) and feces (42.5%) with >90% accounted for in mass balance calculations at 1 week, suggesting that metabolism plays at most a minor role in AMB elimination. In contrast, <10% of the liposomal AMB was excreted unchanged. No metabolites were observed by HPLC or mass spectrometry. In comparison to AMB-DOC, liposomal AMB produced higher plasma exposures and lower volumes of distribution and markedly decreased the excretion of unchanged drug in urine and feces. Thus, liposomal AMB significantly alters the excretion and mass balance of AMB. The ability of liposomes to sequester drugs in circulating liposomes and within deep tissue compartments may account for these differences.

Adult↗

PubMed2003

Informed consent in trials for neurological emergencies: the example of subarachnoid haemorrhage.

BACKGROUND: In patients with acute life threatening diseases, and in their relatives, the ability to make a balanced decision on participation in a clinical trial may be impaired. OBJECTIVES: To assess what relevant information could be recalled by patients who were living independently after a subarachnoid haemorrhage, and by their relatives; and to determine how these patients and relatives had reacted to the informed consent encounter. METHODS: Twenty months (range 7 to 31) after treatment for subarachnoid haemorrhage, 49 patients and 47 relatives who had participated in one of two randomised trials on medical management were interviewed. The interview consisted of items on: spontaneous recall and knowledge of trial design; understanding of the trial design and the informed consent procedure; the amount and clarity of the information given; and reasons for participating. Finally patients and relatives were asked whether they would participate again in similar circumstances. RESULTS: One third of the patients recalled having participated in a clinical trial. Thirteen per cent of the patients and 20% of the relatives felt that the information supplied had not been sufficient. Nine per cent of the patients and half the relatives had read the written information. None of the patients and one relative thought that participation had been obligatory. Twenty eight per cent of the patients and 94% of the relatives felt in retrospect that they had been capable of making an adequate decision. Virtually all patients and relatives would participate again in similar circumstances. CONCLUSIONS: Many patients and their relatives have little recall of the informed consent procedure and the essentials of acute subarachnoid haemorrhage trials. However, most were satisfied with the overall procedure and would participate again.

Decision Making↗

PubMed1982

Tai Chi and ankylosing spondylitis--a personal experience.

On the suggestion of a Chinese physician the author took up Tai Chi, a traditional Chinese exercise, in an attempt to relieve symptoms from his moderately severe ankylosing spondylitis. Conventional medical therapy, used over a 15 year period, had proven of only limited benefit. Tai Chi consists of a series of intricate exercise sequences, and after 2 1/2 years of daily practice the author now feels stronger and healthier than before. Pain, weakness and general malaise return if practice is neglected for as little as one week. It is felt that Tai Chi is of value in minimizing the flexion deformity of the spine. Improved skeletal muscle strength, limb co-ordination, balance, chest movement and ability to relax are further benefits.

China↗

PubMed2004

Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal pregnancy.

It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q10, alpha-tocopherol and gamma-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was observed in serum levels of coenzyme Q10 and alpha-tocopherol (p < 0.001 for each by the Kruskal-Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. gamma-Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed significant association between grades of preeclampsia and both serum coenzyme Q10 and alpha-tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q10 and alpha-tocopherol are potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia.

Adolescent↗

PubMed1980

Ablations of lumbar epaxial musculature: effects on lordosis behavior of female rats.

Ablations of lateral longissimus, medial longissimus, and the lumbar transversospinalis system were performed singly and sequentially on female albino rats. Animals were tested postoperatively with males and by manual stimulation for lordosis. In tests with males, the strength of lordosis was rated specifically with respect to the extent of rump elevation; in manual stimulation tests, rating was based on the full lordotic response. Animals were also tested for the ability to cross a balance beam as an indication of the general status of the animals' posture and locomotion. The data from tests with males proved more sensitive in showing up effects of the ablations on lordosis. Lateral longissimus ablations and transversospinalis ablations led predictably to worsened lordosis. Medial longissimus ablations did not significantly affect lordosis. The manual stimulation data were consistent with the data obtained in tests with males. Ablated animals were not impaired on the balance beam test. The results indicate that lateral longissimus and the lumbar transversospinalis system are major participants in the rump elevation of lordosis, an early and biologically important component of the lordotic response. This information permits focus on lateral longissimus and the lumbar transversospinalis system in the investigation of the neural control of lordosis.

Animals↗

PubMed1996

Chronic hyponatremia due to reset osmostat in a patient with colon cancer.

A 62-year-old man with colon cancer who presented with hyponatremia is described. Volume depletion, renal failure, and cardiac, adrenal, hepatic, and thyroid diseases were excluded as causes of hyponatremia. The urine sodium concentration was repeatedly increased, suggesting the presence of the syndrome of inappropriate antidiuretic hormone secretion. An intact urinary diluting ability and the ability to maintain sodium balance without correcting hyponatremia when the sodium intake was high were consistent with the diagnosis of the reset osmostat variant of the syndrome of inappropriate antidiuresis.

Adenocarcinoma↗

PubMed1995

Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.

Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation versus control in a pig-to-primate cardiac xenotransplantation model in which the binding of xenoreactive antibodies of the recipient to graft blood vessels and the activation of complement cause hyperacute rejection. Human IgG added to human serum caused a dose-dependent decrease in deposition of iC3b, cytotoxicity, and heparan sulfate release when the serum was incubated with porcine endothelial cells. This decrease was not caused by alteration in antibody binding or consumption of complement but presumably reflected decreased formation of C3 convertase on the endothelial cells. Infusion of purified human IgG into nonhuman primates prevented hyperacute rejection of porcine hearts transplanted into the primates. As expected, the transplants contained deposits of recipient Ig and C1q but not other complement components. The inhibition of complement on endothelial cell surfaces and in the xenotransplantation model supports the idea that IgG regulates the classical complement pathway and supports therapeutic use of that agent in humoral-mediated disease.

Animals↗

PubMed2005

PI3K integrates the action of insulin and leptin on hypothalamic neurons.

Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral energy stores. Leptin and insulin have been implicated as circulating indicators of adiposity, but it is not clear how changes in their levels are perceived or integrated by individual neuronal subtypes. We developed mice in which a fluorescent reporter for PI3K activity is targeted to either Agrp or POMC neurons and used 2-photon microscopy to measure dynamic regulation of PI3K by insulin and leptin in brain slices. We show that leptin and insulin act in parallel to stimulate PI3K in POMC neurons but in opposite ways on Agrp neurons. These results suggest a new view of hypothalamic circuitry, in which the effects of leptin and insulin are integrated by anorexigenic but not by orexigenic neurons.

Agouti-Related Protein↗

PubMedDate not supplied

Posturography.

Posturography is a method of measuring a patient's ability to control his balance. Currently available testing techniques may be useful to otologists, although they have not been shown to yield information beyond that obtained from other diagnostic procedures. More powerful techniques are under development, but methodologic problems remain, and none is yet ready for routine clinical use.

Cerebellum↗

PubMed2000

A health and demographic profile of noninstitutionalized older Americans residing in environments with home modifications.

OBJECTIVES: In this analysis the authors investigate the demographic characteristics, the health conditions/events, and the disabilities of community-dwelling Americans 70 years of age and older that are associated with residing in environments with specific home modifications. METHODS: Data from a large population-based study of the elderly are used to estimate logistic regression equations that reveal profiles of older individuals who are likely to have distinct home modifications. RESULTS: Having diseases such as diabetes and stroke, having experienced a hip fracture, a fall or a joint replacement, and having greater limitations with activities of daily living raise the likelihood of having home modifications. Low income, Hispanic, and African American elderly appear underrepresented among those with modifications. DISCUSSION: The authors conclude that specialized housing alternatives will be an increasingly important issue in the future as individuals aim to achieve and maintain the delicate balance between their functional ability and their living environment.

Activities of Daily Living↗