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Results for “Behavior, Addictive”

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At least 451 records · Page 25Linked to original sources

PubMed2003

Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.

Enkephalin modulates striatal function, thereby affecting motor performance and addictive behaviors. The proenkephalin gene is also used as a model to study cyclic AMP-mediated gene expression in striatal neurons. The second messenger pathway leading to proenkephalin expression demonstrates how cyclic AMP pathways are synchronized with depolarization. We show that cyclic AMP-mediated regulation of the proenkephalin gene is dependent on the activity of L-type Ca2+ channels. Inhibition of L-type Ca2+ channels blocks forskolin-mediated induction of proenkephalin. The Ca2+-activated kinase, Ca2+/calmodulin kinase, as well as the cyclic AMP-activated kinase, protein kinase A (PKA), are both necessary for the induction of the proenkephalin promoter. Similarly, both kinases are needed for the L-type Ca2+ channel-mediated induction of proenkephalin. This synchronization of second messenger pathways provides a coincidence mechanism that gates proenkephalin synthesis in striatal neurons, ensuring that levels are increased only in the presence of activated PKA and depolarization.

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine↗

PubMed1999

Coping and social skills training for alcohol and cocaine dependence.

Coping and Social Skills Training (CSST) has been in the forefront of the addictions literature for over two decades. In this review, we provide an outline of empirically validated CSST assessment measures and treatment protocols for alcohol dependence and cocaine dependence. Key elements covered in CSST include communication skills training, cue exposure treatment with urge coping skills, and cocaine-specific coping skills training. We conclude with a summary of the research to date in support of CSSt and future directions for the treatment of addictive behaviors.

Adaptation, Psychological↗

PubMedDate not supplied

Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems.

Neuroadaptation and neurodegeneration in central dopaminergic and serotonergic systems are central to vulnerability, process and consequences of addictive behavior. Serotonergic dysfunction has been associated with behavior disinhibition and negative mood states that may predispose to excessive alcohol intake, while alcohol-induced stimulation of dopaminergic neurotransmission may encode the reinforcing properties of alcohol consumption. Chronic alcohol intake induces neuroadaptive reductions in striatal dopamine transporter (DAT) and D2 receptor availability, which were reversible during early abstinence. A polymorphism of the DAT gene (SLC6A3) was associated with the in vivo transporter availability in the putamen of abstinent alcoholics and control subjects. The same genotype was associated with severity of alcohol withdrawal symptoms, hypothetically due to interactions of genotype and alcohol-induced neuroadaptation. Reduction in raphe serotonin transporter (5-HTT) availability was observed in abstinent male alcoholics and it may be the result of neurodegeneration rather than reversible neuroadaptation. Neurotoxic reduction in 5-HTT protein expression seems to be limited to homozygous carriers of a long, more transcriptionally active allele of a promoter repeat polymorphism of the 5-HTT gene (SCL6A4). This genotype was also associated with a low level of acute unpleasant effects of alcohol consumption, a factor predisposing to excessive alcohol intake. The time course of neuroadaptation and recovery of monoaminergic neurotransmission in alcohol intake and withdrawal imply that monoamine transporter genotype could profoundly influence alcohol-induced reinforcement and, perhaps, contribute to neurochemical changes which are long lasting or permanent.

Adaptation, Physiological↗

PubMed1998

Circadian activity precedes daily methamphetamine injections in the rat.

Scheduled daily injections of methamphetamine (MA) produced locomotor activity that preceded and followed the usual time of injection in rats housed under conditions of constant, moderately dim light and temporally distributed feeding. A circadian basis for pre-injection time activity was supported by its anticipatory timing in the apparent absence of reliable preceding external cues and by its persistence on a test day on which the rats remained undisturbed. Post-injection time locomotor activity also persisted on the test day, occurring from 24 to 29 h after the final MA injection. These results indicate that MA injections engage circadian processes underlying locomotor activity, and they raise the possibility that intake of drugs of abuse by humans may facilitate drug taking or relapse at times of day related to previous drug use.

Animals↗

PubMed1997

A subset of ventral tegmental area neurons is inhibited by dopamine, 5-hydroxytryptamine and opioids.

Neurons originating in the ventral tegmental area are thought to play a key role in the formation of addictive behaviors, particularly in response to drugs such as cocaine and opioids. In this study we identified different populations of ventral tegmental area neurons by the pharmacology of their evoked synaptic potentials and their response to dopamine, 5-hydroxytryptamine and opioids. Intracellular recordings were made from ventral tegmental area neurons in horizontal slices of guinea-pig brain and electrical stimulation was used to evoke synaptic potentials. The majority of cells (61.3%) hyperpolarized in response to dopamine, depolarized to 5-hydroxytryptamine, failed to respond to [Met]5enkephalin and exhibited a slow GABAB-mediated inhibitory postsynaptic potential. A smaller proportion of cells (11.3%) hyperpolarized in response to [Met]5enkephalin, depolarized to 5-hydroxytryptamine, failed to respond to dopamine and did not exhibit a slow inhibitory postsynaptic potential. These two groups of cells corresponded to previously described "principal" and "secondary" cells, respectively. A further group of cells (27.4%) was identified that like the principal cells, hyperpolarized to dopamine. However, these "tertiary cells" also hyperpolarized to both 5-hydroxytryptamine and [Met]5enkephalin and exhibited a slow, cocaine-sensitive 5-hydroxytryptamine(1A)-mediated inhibitory postsynaptic potential. When principal and tertiary cells were investigated immunohistochemically, 82% of the principal cells were positive for tyrosine hydroxylase compared with only 29% of the tertiary cells. The 5-hydroxytryptamine innervation of both these cell types was investigated and a similar density of putative contacts was observed near the somata and dendrites in both groups. This latter finding suggests that the existence of a 5-hydroxytryptamine-mediated inhibitory postsynaptic potential in the tertiary cells may be determined by the selective expression of 5-hydroxytryptamine receptors, rather than the distribution or density of the 5-hydroxytryptamine innervation. We conclude that tertiary cells are a distinct subset of ventral tegmental area neurons where cocaine and mu-opioids both mediate inhibition.

Animals↗

PubMed1999

A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.

This study investigated the effect of ionotropic glutamate receptor agonist or antagonist administration into the nucleus accumbens on the maintenance of cocaine self-administration and the reinstatement of cocaine-seeking behavior. The stimulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or N-methyl-D-aspartate glutamate receptors in the nucleus accumbens with either alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or 1-aminocyclobutane-cis-1,3-dicarboxylic acid, respectively, decreased the number of cocaine-reinforced responses, suggesting an enhancement in the rewarding properties of cocaine. In contrast, blockade of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid receptors with N-methyl-D-aspartate, or N-methyl-D-aspartate receptors with dizocilpine maleate or 2-amino-5-phosphonovaleric acid had no selective effect on the maintenance of cocaine self-administration. Following one week of extinction from the reinforcing cue of the drug-paired lever, both alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid and 1-aminocyclobutane-cis-1,3-dicarboxylic acid treatment in the nucleus accumbens reinstated cocaine-seeking behavior. However, alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid treatment increased responding only on the drug-paired lever, while 1-aminocyclobutane-cis-1,3-dicarboxylic acid increased responding on both the drug-paired and non-drug-paired levers. These results suggest that stimulation of glutamate receptors in the nucleus accumbens augments the reinforcing effect of cocaine, yet glutamate transmission is not required to maintain cocaine self-administration. In addition, increased glutamate transmission in the nucleus accumbens may be involved in facilitating the relapse to cocaine-seeking behavior.

2-Amino-5-phosphonovalerate↗

PubMedDate not supplied

Negative emotional expectancies and readiness to change among college student binge drinkers.

While expectancies are considered to be an important cognitive variable in the etiology and maintenance of substance use, less is known about their role in attitudes toward addictive behavior change. It has recently been suggested that negative alcohol expectancies, in particular, might play a fundamental role in motivation to change. Among a population of college student binge drinkers, the differential ability of positive and negative expectancies to predict total readiness to change (RTC) scores was examined. Hierarchical regression analyses revealed that controlling for level of consumption and number of drinking-related problems, negative and not positive expectancies significantly predicted RTC. In an examination of expectancy subtypes, negative emotional expectancies emerged as the only significant predictor of change motivation. Possible explanations for the findings and implications for interventions with undergraduate heavy drinkers are discussed.

Adolescent↗

PubMed2003

Rapid relapse generally follows treatment for substance use disorders among adolescents.

This prospective study involved 59 adolescents with drug and alcohol disorders who had just completed outpatient treatment. They participated in a comprehensive baseline assessment, and then participated in monthly telephone assessments of substance use and reasons for use. Despite their recent treatment, two-thirds (66%) of the participants in this study had relapsed to drug use within 6 months. The median time to drug relapse was only 54 days (+/-14 days), or slightly less than 2 months. The three most commonly given reasons for relapse were social pressure, withdrawal, and negative affect. These findings provide a first confirmation of the results of S.A. Brown [Recovery patterns in adolescent substance abuse. (1993). In J. S. Baer, G. A. Marlatt, & R. J. McMahon (Eds.), Addictive behaviors across the life span (pp. 160-183). London: SAGE.] in showing that most adolescents relapse quickly following treatment for substance use disorders.

Adolescent↗

PubMed2004

Self-generated alcohol outcomes in 8th and 10th graders: exposure to vicarious sources of alcohol information.

The perceived positive and negative outcomes of alcohol use were studied in a sample of normal 8th and 10th grade students. Participants' responses provided associative frequency norms valuable for future research. Regression analyses showed (1) none of the individual-difference variables (alcohol use, exposure to vicarious sources of alcohol information, such as televised advertising, and demographics) predicted self-generated responses, and (2) alcohol use and first-hand observation of others' drinking did predict the valence respondents assigned to the outcomes. Results support and extend the findings of Stacy, Galaif, Sussman, and Dent [Psychology of Addictive Behaviors 10(1) 1996 18], wherein self-generated drug use outcomes appeared to be available in memory regardless of previous drug use or other individual differences.

Adolescent↗

PubMedDate not supplied

Self-efficacy, attendance, and weight loss in obesity treatment.

Self-efficacy is an important predictor of treatment outcomes for a variety of addictive behaviors. However, little research is available regarding its predictive value in obesity treatment. We assessed the predictive validity of the 20-item version of the Weight Efficacy Lifestyle Questionnaire (WEL) in a consecutive sample of 109 obese adults seeking outpatient treatment at a university-based weight-management center. Although the WEL demonstrated a stable factor structure and sound psychometric properties, it failed to correlate with either program attendance or weight loss. We concluded that self-efficacy judgments (as measured by the WEL) are not predictive of short-term obesity treatment outcomes.

Adolescent↗

PubMedDate not supplied

Motivational profiles of polysubstance-dependent patients: do they differ from alcohol-dependent patients?

Changing addictive behaviors may be conceptualized as a stage phenomenon consisting of precontemplation, contemplation, preparation, action, and maintenance stages. Prior research has provided empirical support for the existence of two discrete motivational subtypes of alcohol-dependent patients (i.e., precontemplation and contemplation/action stage patients). The present study attempted to identify similar motivational profiles for polysubstance-dependent patients and to provide empirical support for the validity of these profiles. Results from a sample of polysubstance-dependent VA patients revealed two clusters consistent with precontemplation (n = 62) and contemplation/action stage (n = 71) profiles, similar to findings from alcohol-dependent samples. Although, as expected, contemplation/action stage patients were more likely to complete treatment than were precontemplators, relatively few differences were noted between these two groups on several other theoretically relevant variables. These results suggest that these subtypes may not identify clinically similar types of patients across alcohol- and polysubstance-dependent samples.

Adult↗

PubMedDate not supplied

The relationship between alcohol problems and use of tranquilizing drugs: longitudinal patterns among American women.

A previous community study of older adults (Graham et al., 1996) indicated a relationship between alcohol problems and use of tranquilizing drugs despite no relationship between alcohol consumption and tranquilizer use. The present paper explores this issue further using longitudinal data from a representative sample of American women. The results replicated previous findings of a significant relationship between alcohol problems and tranquilizer use that was unrelated to alcohol consumption. Analyses of longitudinal patterns indicated that alcohol problems in 1981 predicted subsequent use of tranquilizing drugs and that this relationship may be moderated by anxiety, with the relationship being strongest for respondents who reported few or no problems with anxiety. The results indicated no support for the relationship being due to: a pharmacological interaction of alcohol with tranquilizing drugs; use of tranquilizing drugs precipitating alcohol problems; or depression, anxiety, poor health or childhood sexual abuse being common causes of both alcohol problems and tranquilizer use. The link between alcohol problems and use of tranquilizing drugs needs to be investigated further to increase understanding of addictive behaviors.

Adult↗

PubMed2001

A pilot test of motivational interviewing groups for dually diagnosed inpatients.

Motivational interviewing is a brief treatment approach designed to produce rapid, internally motivated change in addictive behaviors. Motivational interviewing shows promise for engaging clients with dual psychiatric and psychoactive substance use diagnoses in treatment. While initially developed as an individual treatment approach, key motivational enhancement principles may be applied to structured group interventions to facilitate its introduction to inpatient dual-diagnosis treatment. We describe how we developed and pilot-tested a motivational interviewing group for dually diagnosed inpatients, and illustrate successes and pitfalls in clinical implementation. Group participants were readily engaged by the entertaining format and often provocative content, and appeared to benefit from exploration of their ambivalence regarding change. Directions for further development and evaluation are proposed.

Adolescent↗

PubMed2002

Dual Diagnosis Motivational Interviewing: a modification of Motivational Interviewing for substance-abusing patients with psychotic disorders.

Motivational Interviewing (MI) is a brief treatment approach for helping patients develop intrinsic motivation to change addictive behaviors. While initially developed to target primary substance using populations, professionals are increasingly recognizing the promise this approach has for addressing the motivational dilemmas faced by patients who have co-occurring psychiatric and psychoactive substance use disorders. Unfortunately, this recognition has not lead to a clear explication of how MI might be adopted for specific diagnostic populations of dually diagnosed patients. In this article we describe how we have applied the principles and practices of MI to patients who have psychotic disorders and co-occurring drug or alcohol use problems. Specifically, we provide two supplemental guidelines to augment basic MI principles (adopting an integrated dual diagnosis approach, accommodating cognitive impairments and disordered thinking). We present recommended modifications to primary MI skill sets (simplifying open-ended questions, refining reflective listening skills, heightening emphasis on affirmation, integrating psychiatric issues into personalized feedback and decisional balance matrices). Finally, we highlight other clinical considerations (handling psychotic exacerbation and crisis events, recommended professional qualifications) when using MI with psychotic disordered dually diagnosed patients.

Adult↗

PubMed2001

Effects of the kappa-opioid receptor agonist, U69593, on the development of sensitization and on the maintenance of cocaine self-administration.

Previous studies showed that prior administration of kappa-opioid agonists decreased the development of sensitization to some of the behavioral effects of cocaine. The present study sought to determine whether the development of sensitization to cocaine's reinforcing effects was also sensitive to antagonism by kappa-opioid agonists. During a pretreatment phase, the kappa-opioid agonist, U69593 (0.0 or 0.32 mg/kg) was administered prior to (1) 2 daily injections of cocaine (0.0 or 20.0 mg/kg), or (2) cocaine or saline administered via a yoking procedure. Cocaine pretreatment decreased the latency to acquisition of cocaine self-administration. However, prior administration of U69593 during the pretreatment phase failed to attenuate the development of this sensitized response to cocaine's reinforcing effect. In other groups, the effect of acute U69593 pretreatment on the maintenance of cocaine self-administration was examined during a 10 hr session. During training and testing, a stimulus was associated with each self-administered cocaine infusion for one group whereas responding of another group was reinforced by a cocaine infusion alone. On the test day, pretreatment with U69593 (0.32 mg/kg) decreased responding during each hour of the 10 hr session for the group that was reinforced with cocaine plus the cocaine-associated stimulus. U69593 failed to produce a long-lasting disruption of cocaine self-administration for rats that were trained and tested without the cocaine-associated stimulus. These data suggest that the acquisition and maintenance of cocaine self-administration are differentially sensitive to manipulations of kappa-opioid systems. Further, the disruption of cocaine self-administration by U69593 may be due to interactions with mechanisms that underlie facilitative effects of stimuli that have been associated with self-administered cocaine infusions.

Animals↗

PubMed1990

Conditioning arbitrary stimuli to cigarette smoke intake: a preliminary study.

This study represents an attempt to classically condition arbitrary stimuli to cigarette smoke intake. A smoker either smoked or mock-smoked a cigarette in two discriminative contexts for 20 sessions. The contingencies were reversed during an additional last two sessions. Measures of heart rate, skin temperature, and puff duration were monitored during all sessions. Results suggested that both manipulations of smoke delivery and context cues were related to puff duration. The pattern of psychophysiological reactivity was mixed and not easily interpreted. This experimental paradigm may be useful in the investigation of conditioning factors underlying addictive behaviors.

Adult↗

PubMed1990

Issues in relating self-efficacy to smoking relapse: importance of an "Achilles' heel" situation and of prior quitting experience.

Self-efficacy (SE) has predicted relapse in numerous studies of addictive behaviors. This smoking relapse project extended previous SE research in two ways. First, the hypothesis that low SE influences behavior more than does high SE (Wallston, Wallston, Smith & Dobbins, 1987) was evaluated. As predicted, SE in a subject's least confident high-risk situation predicted continuous abstinence in the following 12 months as strongly as did SE averaged across all situations. This result is consistent with the practice of targeting very-low-SE situations for skill training. Second, Bandura's (1977) postulate that direct behavioral experience is the most reliable basis for forming SE judgments was tested. Contrary to prediction, subjects with more past experience in smoking cessation attempts did not make SE ratings of higher predictive validity. Possible roles of dispositional optimism and the preferential use of positive instances in forming predictions are discussed in accounting for this finding.

Adult↗

PubMed1994

General and specific locus of control in cocaine abusers.

Although the struggle for control has been widely recognized as a central feature of addiction, information about its role in the development and maintenance of addictive behavior is limited. This study compared general and specific locus of control in three groups of cocaine abusers: (a) hospitalized subjects with no prior treatment experience, (b) hospitalized subjects with prior treatment experience, and (c) recovering cocaine abusers. Results of initial analyses of variance revealed significant group differences on both general and specific scales. Scores of recovering cocaine abusers were more internal than those of hospitalized subjects. Differences on the general scale were not significant when age was controlled. No significant differences were noted between the two groups of hospitalized subjects, but scores of hospitalized cocaine abusers made an internal shift over the course of treatment. These findings support generalizability of models previously applied to alcoholics and suggest that internality is positively correlated with recovery.

Adult↗