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Cysticercosis: an unusual cause of papilledema.

A case of cerebral cysticercosis with papilledema is presented in a 44-year-old Mexican woman who progressed to optic atrophy despite a ventriculoatrial shunt. The diagnosis was made on testing the cerebral spinal fluid for the indirect hemagglutination response to cysticercosis. The problems of the pork tape-worm as well as several references from the literature are discussed pertaining to ocular and cerebral involvement. Although this disease is not common in the United States we should think of it in cases of papilledema in patients from endemic areas and in those who have traveled in those areas and eaten pork not properly cooked or frozen.

Adult↗

[Subcutaneous cysticercosis and neurocysticercosis].

Two cases, one of subcutaneous cysticercosis and one of neurocysticercosis, are described--both in young women, who had been in Mexico and ex-Yugoslavia, respectively. Neurocysticercosis is the most common neuroparasitosis in the world (and probably the reason for 2/3 of the cases of epilepsy) and as travels to endemic areas and immigration are on the increase, general practitioners should have cysticercosis in mind when treating a patient with subcutaneous noduli or cerebral symptoms.

Adult↗

Cysticercosis in laboratory rabbits.

There are no data on the current incidence of Taenia pisiformis in laboratory rabbits. Two cases of cysticercosis most likely due to T. pisiformis in laboratory rabbits (intermediate host) are presented. Both rabbits had no contact with dogs (final host); their caretakers did not work with dogs, and these caretakers changed into facility scrubs and wore gloves when working with the rabbits. Rabbit 1 may have been infected after being fed hay at our facility. In light of the life cycle of the parasite and the history of rabbit 2, it potentially could have been infected prior to arrival at our facility. There have been only three cases of tapeworm cysts in rabbits in our facility (average daily census, 250) during the last 10 years (incidence, < 1%). This report indicates that although cysticercosis is rare in laboratory rabbits, one should always be aware of such incidental findings. Although it may not produce overt illness in the rabbit, hepatic migration could adversely affect the outcome of some experimental procedures

Animals↗

Lingual cysticercosis--a case report.

Cysticercosis is unlikely to be the first diagnosis for a swelling over the tongue. In this report we document an unusual case of lingual cysticercosis presenting as an isolated lesion.

Adolescent↗

[Cysticercosis in the port of Mahajanga: more frequent than we thought!].

A seroepidemiological survey was carried out in July 1999 to assess the prevalence of cysticercosis in general population in the Mahajanga City (West of Madagascar). Blood specimens were collected from a randomised sample including 626 individuals more than 2 years old. ELISA and confirmative immunoblot techniques (EITB) were used to measure Cysticercus cellulosae antibodies. The overall prevalence by ELISA test was 19% (15.8-22.7% CI95%). Among positive cases, 87% were also positive by EITB. Cysticercosis is considered as major health problem in Madagascar. A national control programme implementation is imperative.

Adolescent↗

Significance of western blot in diagnosis of cysticercosis cellulosae.

Sodium dodecyl sulphate (SDS) polyacrylamide gradient gel electrophoresis (PAGE) and immunoblot were used for the diagnosis of patients with cysticercosis cellulosae. 26 KD protein band of the whole Cysticercus antigen showed a high specificity to the sera from patients with cysticercosis cellulosae and had no cross reaction with sera from normal controls and other parasitic diseases including hydatidosis. The positive rate of Western blot with 26 KD band was 70% and the results showed no significant difference in comparison with those of CFT and ELISA.

Animals↗

Spontaneous extrusion of cysticercosis: report of three cases.

We report three cases of spontaneous extrusion of cysticercosis. In two cases, it got extruded from the orbit and in one case from the subconjunctival space. Extrusion of cysticercosis was associated with improvement in clinical signs and symptoms.

Adolescent↗

[A follow-up study of 420 cases of cerebral cysticercosis].

420 patients with cerebral cysticercosis, including 97 with intracranial hypertension, were treated by praziquantel 30-50 mg/kg a day, 7-10 days a course. Of the 420 patients, 252, 144 and 24 were treated for one, two and three courses respectively. 1-6 years' follow-up study showed 366 were completely recovered (87.14%) and 399 had effect (95.00%); 12 had inefficacy and 9 died (5.00%). It is believed that the serious acute allergic reactions might be eliminated by "desensitization" of a small dose of praziquantel; intracranial hypertension can be lowered by intrathecal injection of dexamethasone; and ventricular and intra-ocular cysticercosis can also be treated by praziquantel.

Adolescent↗

Short report: Evidence and potential for transmission of human and swine Taenia solium cysticercosis in the Piracuruca region, Piauí, Brazil.

The study conducted in the Cocal dos Alves municipality, located in the Piracuruca region of Piauí State, Brazil in November of 2003 was based on both a socio-behavioral survey and analysis of serum antibodies and parasitic materials. Pig raising is the main economic activity with 91.4% using extensive farming. On the studied population, 54.3% of people did not apply any sanitary measures to wastewater, 45.7% used septic tanks, and 69.1% consumed water without treatment. The data collected indicated the occurrence and active transmission of the taeniasis-cysticercosis complex in the region. One of seven voluntary persons was positive in antibody-ELISA tests using both native and recombinant antigens. Multiplex PCR and DNA sequencing of cyst samples obtained from a pig revealed the presence of the Afro-American genotype of Taenia solium. This study revealed the occurrence of human and porcine cysticercosis in the Piracuruca region of Piauí State, middle-north of Brazil.

Animals↗

Laboratory diagnosis of cysticercosis.

Human cysticercosis is caused by cystic tissue larvae of Taenia solium acquired by ingesting the eggs of the T. solium tapeworm. The diagnosis of human cysticercosis can be made by radiologic imaging, tissue biopsy, or serology. Radiologic imaging, including MRI and CT, currently is the most effective means for diagnosis.

Animals↗

A case-control study of risk factors in light Taenia saginata cysticercosis in Danish cattle.

Risk factors in light T. saginata cysticercosis in cattle herds were investigated in a case-control study. The case group consisted of farms from which cattle with low-grade cysticercosis had been detected at slaughter. The control group consisted of farms where no cases were detected during the same period. The major risk factor identified was allowing cattle access to drink from streams carrying effluent from sewage treatment plants (odds ratio = 3.6). Spreading of septic tank sludge through deliberate or accidental mixing with animal slurry, deposition of sewage sludge, and proximity to railways, camping sites or sewage treatment plants seemed to be of minor importance.

Animals↗

Removal of submacular cysticercosis: a case report.

We report a case of submacular cysticercosis which was removed by pars plana vitrectomy and retinotomy with favorable result. Preoperative visual acuity was counting fingers of one foot and improved to 10/200 at five weeks postoperatively. The technique illustrates another approach to the surgical management of submacular cysticercosis. It is also applicable for removal of posterior location of subretinal cysticercus which it is difficult or impossible to approach externally.

Adult↗

Development of a serologic assay for cysticercosis, using an antigen isolated from Taenia spp cyst fluid.

An ammonium sulfate-soluble fraction of Taenia hydatigena cyst fluid (ThFAS) was further evaluated for use in the immunodiagnosis of cysticercosis. Analysis of ThFAS by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and protein immunoblot analysis confirmed earlier reports of a highly specific, low molecular weight antigen in this preparation; in contrast, other components of ThFAS were shown to react nonspecifically. Antibodies against the less than 12-kD diagnostic antigen were detected in sera from 10 cattle and 4 swine inoculated with metacestodes of T saginata and T solium, respectively, but not in animals inoculated with Fasciola hepatica, Trichinella spiralis, Brucella abortus, or Toxoplasma gondii, or in noninoculated controls. Isolation and immobilization of the less than 12-kD antigen on a hydrophobic transfer membrane resulted in development of an unambiguous dipstick assay capable of correctly identifying fully developed (10-week) experimentally induced infections in cattle and swine. In addition, the dipstick assay was highly specific for diagnosis of the disease in human beings, and offers the potential of distinguishing between human clinical cases of cysticercosis and taeniasis. A similar reactive antigen of diagnostic potential was also identified and isolated from T crassiceps and T taeniaeformis cyst fluids.

Animals↗

[IgE and IgE-mediated immunoreaction in the pathogenesis of human cysticercosis].

Total IgE, specific IgE and histamine in sera from 35 documented cases of cysticercosis and 30 transfusion donors were measured and mast cell degranulation test was performed. Total IgE levels (730.61 U/ml), the positive rate of specific IgE (85.7%), histamine levels (5.3 micrograms/ml) and the positive rate of mast cell degranulation (42.9%) of the patients were found to be significantly higher than those of the normal group (P less than 0.01). The results suggested that the antigen of Cysticercus cellulosae could induce IgE production and mast cell degranulation, resulting in the release of histamine. It was, therefore, deemed that the IgE and IgE-mediated immunoreaction might be involved in the pathogenesis of human cysticercosis.

Adult↗

[Human cysticercosis. Four cases (First part) (author's transl)].

Produced by the larval form of Taenia solium, human cysticercosis is especially redoutable because of its great affinity for the nervous system and the eyes. In France, the isolated cases, apparently autochtons, are very seldom; cysticercosis is discovered, more frequently, among immigrated people. After an historical recall, the authors describe the lesions and, among clinical manifestations, the epileptogenic, ventricular and diffuse cerebral forms.

Adult↗

[Analysis of brain CT in 120 patients with human cysticercosis].

A study on brain CT was made in 120 patients of human cysticercosis, which is a rare disease in Japan and clinical symptoms and laboratory data for the diagnosis were also discussed. From the point of therapeutic view, we proposed a new differentiation on brain CT of human cysticercosis, which is divided into two groups according to the alive or dead parasite. Furthermore, we proposed a new type named multiple large and small cysts type on brain CT. The idea of diagnostic standard was made integrating brain CT image, clinical symptoms and laboratory data.

Adolescent↗

[Diagnostic problems in the disseminated intraparenchymatous form of cerebral cysticercosis. A report on two cases (author's transl)].

The authors report 2 cases of brain localisation of cysticercosis due to Cysticercus cellulosae. In both cases epilepsy was found but only later was its origin proved by the finding of caracteristic ellipsoidal calcifications of cysticerci on the roentgenogram. The authors also recall the various possible symptoms; insist on the fact that early positive diagnosis is difficult and that the mode of treatment by surgery is exceptional. Though cysticercosis is rare in France, it should be remembered when a diagnosis of epilepsy is made and no apparent cause is found: further research of etiology should thus be made in such cases.

Brain Diseases↗