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PubMed1999

Generators of brain electrical activity in patients with Wilson's disease.

Electroencephalographic (EEG) generators were investigated in 13 patients suffering from hepatolenticular degeneration with and without neurological symptoms and in 13 healthy subjects for comparison by the use of FFT approximation. Quantitative assessment of motor deficits and psychiatric disturbances was correlated with EEG features. We found mainly an increase in delta activity, a decrease in alpha activity combined with a more posterior localisation of the EEG generators in the delta band and a more anterior one in the alpha band in patients compared with healthy controls. The localisation of the EEG generators in the patients with clinical apparent neurological symptoms were in all frequency bands more superficial compared with controls and patients without neurological symptoms. With longer duration of the disease, the lower the premorbid intelligence the more posterior was the delta EEG generator localised. Although the alpha EEG generator was more anteriorly localised with longer duration of the disease and more severe cognitive deficits, it was more superficial with more pronounced psychiatric symptoms, more severe cognitive deficits, lower premorbid intelligence and more pronounced motor disabilities. With more pronounced psychiatric symptoms and cognitive deficits, the beta EEG generator was more anteriorly localised. The present study demonstrated that a significant deviant EEG pattern exists between patients with and without clinical neurological symptoms and that stage-dependent alterations in psychiatric symptoms and cognitive ability are reflected on the EEG.

Adult↗
PubMedDate not supplied

[Morphology of demyelination plaques vs cognitive and emotional disorders in multiple sclerosis patients].

The interrelationship between psychological examination and MRI findings was studied in 70 patients with MS. The cognitive and emotional functions were examined by a battery of tests: Wechsler Adult Intelligence Scale, Visual Retention Test, Hamilton Depression Scale. In MRI examination the localization, area, and the morphology of the plaques were examined. According to plaque's morphology the patients were divided into two groups: with confluent plaques and those with patchy-shaped ones. The signs of dementia were found significantly more frequently in the group with confluent plaques (p. < 0.04). In this group of patients also single-function disorders like disturbances of verbal memory, attention, visual memory, cause- and effect thinking, abstract thinking, and visual-motor coordination were significantly more frequent (p. < 0.01). In the same group the signs of fatigue syndrome were more frequently encountered (p. < 0.02). The authors conclude that the disturbances found in cognitive function may reflect the symptoms of subcortical dementia in MS patients.

Adult↗
PubMed2001

Cognition in schizophrenia.

Cognitive dysfunction has been described as a hallmark feature of schizophrenia since the first descriptions of the illness. Kraepelin described a number of features of the disorder that he thought reflected impairments in cognition and attention. He also speculated that cognitive impairments were mediated by neurobiologic dysfunction, specifically impairments in the functions of the frontal lobe. Since Kraepelin's time, there have been many changes in the general conceptions of schizophrenia, including ideas regarding the status and importance of cognitive impairment in the illness. Due to increased sophistication of neuropsychologic assessment and neuroimaging techniques, cognitive impairment has again has risen to the forefront of importance in terms of theories regarding the etiology and treatment of schizophrenia.

Attention↗
PubMed1997

A study of cognitive development and behavior problems in mentally retarded children.

Cognitive development in seventy-one mentally retarded children (19 autistic, 52 non-autistic; aged 7-19 years) from a school for handicapped children was studied, using Ohta's scale for evaluating cognitive development level based on language comprehension (Ohta's stage), and other developmental scales. Behavior problems were also examined. The present study reports on the utility of Ohta's stage in non-autistic children, and the relationship between cognitive development level and behavior problems in mentally retarded children. In non-autistic children, there were temporal correlations between Ohta's stage and other development scales (a standard developmental test, speech development, symbolic play development, imitation development), suggesting that in non-autistic children as well, Ohta's stage may serve well as a scale for cognitive development, and reflect symbolic representational functioning. In non-autistic children, most behavior problems in feeding, elimination and sleeping, hyperkinesis, hypokinesis, stereotyped behaviors, self-injurious behavior and licking were closely associated with cognitive development level, and were more often noted in children of lower cognitive development level rather than only in the severely mentally retarded children. Some behavior problems may often occur in the sensorimotor period and hardly occur in the symbolic representational period.

Adolescent↗
PubMed1995

Development and testing of a measure of depressive cognitions in older adults.

Assessment of cognitive processes that predispose or contribute to clinical depression in elders is important for planning interventions that facilitate positive cognitive appraisal and effective coping strategies. Instruments evaluating severity of depression exist; however, none measure specific depressive cognitions. This paper describes the development and pilot testing of the Depressive Cognitions Scale (DCS) for older adults. Derived from Erikson's Psychosocial Theory, the 8 items comprising the scale were selected by clinical experts from a pool of 24 items. Each item reflects a depressive cognition that may arise from less than successful resolution of one of Erikson's developmental phases. Psychometric testing of the DCS was conducted with 60 functionally independent, community dwelling older adults (age 65+). An alpha of .78 indicated acceptable internal consistency. Construct validity was demonstrated by significant correlation with measures of psychosocial development. Further psychometric study of the DCS is recommended.

Aged↗
PubMed2000

Cognitive sequence processing and syntactic comprehension in schizophrenia.

It has been repeatedly demonstrated that schizophrenic patients are impaired in the comprehension of sentences with complex syntax. We investigated the hypothesis that this syntactic comprehension impairment in schizophrenia is not a purely linguistic dysfunction, but rather the reflection of a cognitive sequence processing impairment that is revealed as task complexity increases. We tested 10 schizophrenic patients using a standard measure of syntactic comprehension, and a non-linguistic sequence processing task, both of which required simple and complex transformation processing. Patients' performance impairment on the two tasks was highly correlated (r2 = 0.84), and there was a significant effect for complexity, independent of the task. These results are quite similar to those of aphasic patients with left hemisphere lesions. This suggests that syntactic comprehension deficits in schizophrenia reveal the dysfunction of cognitive sequence processing mechanisms that can be expressed both in linguistic and non-linguistic sequence tasks.

Adult↗
PubMed2001

Metamemory and tested cognitive functioning in multiple sclerosis.

Metamemory, or one's knowledge and self-report of memory ability, has been researched extensively; however, few studies have examined it in multiple sclerosis (MS). Because impairment in cognitive domains besides memory may affect memory functioning, patients may self-report problems with memory that are indicative of impairment in cognitive domains besides memory. One goal of the current study was to test this hypothesis in MS. A group of 55 MS patients were administered a variety of cognitive tasks and a self-report metamemory measure; patients' significant others were also given a metamemory measure requiring them to rate patients' memory abilities. Results indicated that patients' metamemory reports were significantly (p < .05) correlated with verbal recall, attentional, and executive tasks. Significant other ratings of patients' metamemory were correlated with verbal recall and attentional measures. Stepwise regression analyses including all relevant cognitive and demographic variables indicated that only education and Symbol Digit accounted for significant independent variance in patients' current memory reports. Our results suggest: (1) subjective complaints of memory difficulties by MS patients reflect difficulty in cognitive domains besides memory, (2) MS patient self-reports of memory difficulty are at least as accurate as significant other reports, and (3) patients with more education are more accurate in their metamemory ratings. These findings have implications not only for a better understanding of metamemory in MS, but also for more effective treatment and rehabilitation of MS patients.

Cognition Disorders↗
PubMed2006

On misattributing good remembering to a happy past: An investigation into the cognitive roots of nostalgia.

Reflections on the past are often accompanied by an experience of nostalgia, or positive sentiments about some prior stage of one's life. In the current study, we provide evidence suggesting that nostalgic experiences may occur because of positive feelings that accompany the act of successful recall, rather than reflecting the true nature of the past. In a series of experiments, we employed an encoding manipulation to cause some words to support more detailed recollections than others. In turn, we measured the effect of these manipulations on judgments of both pleasantness and the emotional valence of a prior stimulus encounter. We demonstrate that recollections rich in meaning are unique in biasing people to judge having previously seen a stimulus in an emotionally positive context. In contrast, pleasantness judgments appear to be guided primarily by perceptual fluency. Overall, our results are consistent with the notion that the subjective experience of nostalgia represents a misattribution of successful remembering to a pleasant past.

Adult↗
PubMed1986

Event-related potentials of the brain and cognitive processes: approaches and applications.

Event-related potentials (ERPs) are recordings of the electric field which the brain produces in fixed time-relation to an event. ERPs open a time and space window onto covert steps of brain information processing which need not be accompanied by overt behavior or private experiences. ERPs are the only noninvasive method which resolves the dynamic pattern of events in the human brain down to the millisecond range. Early ERP components are valuable tools in clinical testing of the afferent sensory systems in the absence of anamnestic or clinical pathology. Later components (e.g. the 'P300') index intermediate, covert steps of information processing and have clarified the time course and the contingencies of processes in attention, decisions and language. ERP waveshapes show electric potential differences between two recording points. Conventional analysis often ignores the fact that there is no unique voltage amplitude or signal latency for a single point, and interprets ambiguous results. Although important insights have emerged with such strategies, full utilization of ERP data requires unambiguous ERP assessment and converging evidence from neuropsychological and cognitive experimentation. Sequences of field distribution maps offer an unbiased display of ERP data. Spatial analysis yields unambiguous values for further comprehensive assessment, and should precede analysis over time. Examples of spatial analysis have shown that different ERP field configurations follow the presentation of noun and verb meaning of homophone words; that the ERP effects to subjective contours resemble those to attention in time course and topography; that the 'cognitive' P300 component reflects the specific stimulus location; and that subliminal information influences the configuration of late ERP fields.

Attention↗
PubMed1998

Dysprosody after severe closed head injury: an acoustic analysis.

OBJECTIVES: Neurological speech disorders (dysarthria and dysprosody) are known to be frequent sequelae after severe closed head injury. These disorders may dramatically alter communicative intent and accentuate social isolation. The aim was to provide an instrumental evaluation for prosodic production in a group of patients with severe closed head injury and to determine the correlations between prosodic production and neurobehavioural status. METHODS: Fifteen patients, at the subacute stage after severe closed head injury, were studied and compared with 11 controls, matched for age, sex, and duration of education. Each subject was required to read aloud a French sentence "Je m'en vais samedi matin" (I am leaving saturday morning) under six different prosodic intonations (neutral, affirmation, interrogation, happiness, sadness, anger). The recorded sentences were analysed using a sound signal analysis software (Signalyse) allowing the measurement of signal intensity and fundamental frequency. Statistical analyses were carried out using repeated measures analysis of variance (ANOVA). RESULTS: Patients with closed head injury were significantly less able than controls to modulate speech output (pitch and intensity) according to prosodic context. This deficit was particularly pronounced for the intonation feature of anger, question, and statement. No consistent correlations could be found between prosodic production and cognitive or behavioural data. CONCLUSIONS: Acoustic analysis of pitch and intensity may show impairments of prosodic production after severe closed head injury, which may be useful in rehabilitation planning. This impairment does not seem to reflect the eventual cognitive and behavioural deficits of the patients, but rather a specific disorder of modulation of speech output.

Adolescent↗
PubMed2005

Does electroconvulsive therapy (ECT) affect cognitive components of auditory evoked P300?

Electroconvulsive therapy (ECT), as a treatment tool for psychiatric disorders, is believed to be safe and effective. Nevertheless, it has a negative impact on cognitive functioning, especially on memory, causing both retrograde and anterograde amnesia. However, ECT effects on more subtle stages of information processing are not studied enough. Event-related potentials, and especially P300, are thought to reflect physiology of cognition. Thus, we aimed to evaluate the effects of ECT treatment on parameters of endogenous components (N2, P3) of the P300 potential. Seventeen patients suffering from schizophrenia, schizoaffective disorder and recurrent depressive disorder participated at the study. After the course of ECT, significant increase of N2 amplitude in parietal midline region and prolongation of P3 latency in frontal midline region, of which the magnitude positively correlated with the number of ECT procedures, have been obtained.

Adult↗
PubMed1994

Callosal morphology and performance on intelligence tests.

Variation in the size of the human corpus callosum was examined in relation to variation in measured IQ. The midsagittal surface area of the corpus callosum, obtained by magnetic resonance imaging, was measured in 47 patients with epilepsy. Intellectual ability was positively related to a larger posterior callosal area. We suggest that the relationship between the posterior callosal region and measured intelligence is "non-functional" in itself, but rather, may reflect other anatomical-cognitive associations. That is, differences in splenial size may reflect differences in the number of cortical neurons and interconnections between areas of the brain that are important for processing the kind of information measured on intelligence tests. Our conclusions, however, must be tempered by a number of factors; in particular, the nature of our subjects and the relatively small sample size.

Adolescent↗
PubMed2006

Cognitive rehabilitation interventions for executive function: moving from bench to bedside in patients with traumatic brain injury.

Executive function mediated by prefrontally driven distributed networks is frequently impaired by traumatic brain injury (TBI) as a result of diffuse axonal injury and focal lesions. In addition to executive cognitive functions such as planning and working memory, the effects of TBI impact social cognition and motivation processes. To encourage application of cognitive neuroscience methods to studying recovery from TBI, associated reorganization of function, and development of interventions, this article reviews the pathophysiology of TBI, critiques currently employed methods of assessing executive function, and evaluates promising interventions that reflect advances in cognitive neuroscience. Brain imaging to identify neural mechanisms mediating executive dysfunction and response to interventions following TBI is also discussed.

Animals↗
PubMed2006

Autobiographical memory in the euthymic phase of recurrent depression.

The authors investigated autobiographical memory specificity in subjects who formerly had depression. In 122 euthymic patients with at least two previous major depressive episodes, memory specificity was significantly impaired compared to matched control participants but not related to residual symptoms and illness characteristics, was not differentially affected by cognitive therapy, and was also not predictive of relapse/recurrence during the 2-year follow-up. However, memory specificity was associated with age, education, and immediate and delayed memory recall. The results suggest that memory specificity may reflect a global cognitive impairment that remains in patients who (formerly) had depression but does not constitute a trait marker for vulnerability for relapse/recurrence.

Adult↗
PubMed2000

Methodologic support in habilitation and rehabilitation: communicative action between practice and science.

This study evaluated the early phase of development of a model for quality improvement of habilitation and rehabilitation project processes. The focus of the methodologic support in habilitation and rehabilitation model was on cooperation between practice contexts and science. Habermas' theory about communicative action was a theoretical frame of reference. Three project coordinators and ten project leaders were interviewed. The results revealed different attitudes towards methodologic support activities, demonstrating the importance of acknowledging cognitive and social functions, the process of legitimization, different approaches of practice versus science, and problems regarding information and communication. The model was shown to be important in bridging the gap between practice and science. To support reflective and emancipatory cognitive learning, more efforts to foster communicative action are called for, and more attention must be paid to the importance different missions and organizational structures have for the development of the dialog between practitioners and researchers.

Allied Health Personnel↗
PubMed2006

Height at age 18 years is a strong predictor of attained education later in life: cohort study of over 950,000 Swedish men.

BACKGROUND: Adult body height has been related to socioeconomic position in cross-sectional studies. Intelligence, shared family factors, and non-familial circumstances may contribute to associations between height and attained education, but their relative importance has been difficult to resolve. METHODS: A nation-wide record-linkage cohort study of over 950 000 Swedish men born 1950-75 followed with respect to attained education for up to 27 years after measurement of height at age 18 (baseline). The association between height and attained education in later life was investigated by logistic regression modelling with adjustment for age, geography, parental socioeconomic position, and cognitive ability. Shared family factors were accounted for in analyses of full-brother-pairs using conditional logistic regression. RESULTS: The odds ratio (OR) for attaining higher education 7-27 years after baseline was 1.10 [95% confidence interval (95% CI) 1.09-1.10] in fully adjusted models per 5 cm increase in height. Men taller than 194 cm were two to three times more likely to obtain a higher education as compared with men shorter than 165 cm. The association remained within brother-pairs, OR 1.08 (95% CI 1.07-1.10), suggesting that non-familial factors contribute to the association between height and education attainment. A significant interaction (P < 0.0001) was found between year of birth, height, and attained education, showing slightly weaker associations among later birth cohorts. CONCLUSIONS: The strong positive association between height and educational achievement remaining after adjustment for year of birth, parental socioeconomic position, other shared family factors, and cognitive ability may reflect educational discrimination based on height although residual confounding cannot be ruled out.

Adolescent↗
PubMed2004

The influence of immunomodulation on psycho-neuroimmunological functions in benign multiple sclerosis.

OBJECTIVES: In multiple sclerosis (MS), several neuroimmunomodulatory effectors are known, including melatonin. They are able to influence disease-related neurophysiogical changes (disability or impaired vision) as well as neuropsychological performance (e.g. cognition and depression). In this study we assessed the relationship between immunomodulation on psycho-neuroimmunological functions in benign multiple sclerosis. METHODS: We evaluated 26 young female patients with benign MS treated with/without immunomodulating therapies with regard to their physical disabilities (Expanded Disability Status Scale, EDSS), their visually evoked potentials (VEP), their plasma melatonin concentrations as well as their performance regarding emotional and cognitive tests and compared them with healthy matched controls. RESULTS: Patients with MS showed deficits in cognitive and emotional functions compared to healthy controls, which were in accordance with their increase in EDSS over time. However, in contrast to untreated patients, patients receiving immunotherapy showed significantly increased dysfunction with respect to actual mood (p = 0.02) and a tendency to increased depression scores (p = 0.072). However, neither treatment subgroup had cognitive deficits. In untreated patients, melatonin levels correlated with reduced scores in the cognitive tests (p = 0.045) but not with depression or VEP latencies. Patients with long-standing MS (>10 years) showed a significant correlation (p = 0.01) to their increased depression scores and their melatonin levels, but no correlation with VEP or cognitive dysfunction, compared to patients with shorter disease duration (< or =10 years). CONCLUSION: These results indicate that in MS all aspects of the psycho-neuroimmunological network can be affected. Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected. However, visual perception as well as visuoconstructive abilities were affected in MS patients. Neuropsychological tests in MS should concentrate on cognitive variables, which reflect the clinical status more accurately and may be used to monitor disease-modifying therapies.

Adult↗