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At least 451 records · Page 25Linked to original sources

PubMed2005

The establishment of the photo management system for orthodontics and its clinical application.

It is necessary for orthodontists to collect and analyze the patients' photographic data. By conventional methods, these photo data were commonly saved on film, which were frail and often resulted in data loss. Furthermore, it is not convenient for the orthodontists to consult and study these data during clinical research. A critical problem thus arises in managing these photo data scientifically. The computer technique and picture processing method were employed in the present study to establish the Photo Management System for Orthodontics (PMSO), which makes the administration of patients' photo data more scientific, convenient, and effective than before. This system is characterized as follows: (1) Clinical orthodontists designed and programmed the system, which is "close to clinical reality and serves the clinic". Orthodontists can easily use it without any training course. (2) The images can be imported from many devices, such as digital cameras, scanners, and electronic data storage media such as floppy disks. (3) Even two groups of photos (four images) could be displayed in the same window for comparison and study. This function allows orthodontists to easily observe the differences in the same patient's photos at different stages, which is important to obtain comprehensive knowledge of the patient. (4) The network technique makes it possible for the photos to be shared. The orthodontists can get the patients' photos through the network without going to the radiology department or the imaging room. (5) It is helpful for orthodontic research since the photos can be exported easily in different ways. (6) This is shared software; orthodontists can use it for free.

Computer Communication Networks↗

PubMed1992

Sequencing by hybridization: towards an automated sequencing of one million M13 clones arrayed on membranes.

An immediately applicable variant of the sequencing by hybridization (SBH) method is under development with the capacity to determine up to 100 million base pairs per year. The proposed method comprises six steps: (i) arraying genomic or cDNA M13 clones in 864-well plates (wells of 2 mm); (ii) preparation of DNA samples for spotting by growth of the M13 clones or by polymerase chain reaction (PCR) of the inserts using standard 96-well plates, or plates having as many as 864 correspondingly smaller wells; (iii) robotic spotting of 13,824 samples on an 8 x 12 cm nylon membrane, or correspondingly more, on up to 6 times larger filters, by offset printing with a 96 or 864 0.4 mm pin device; (iv) hybridization of dotted samples with 200-2000 32P-labeled probes comprising 16-256 10-mers having a common 8-mer, 7-mer, or 6-mer in the middle (20 probes per day, each hybridized with 250,000 dots); (v) scoring hybridization signals of 5 million sample-probe pairs per day using storage phosphor plates; and (vi) computing clone order and partial-to-complete DNA sequences using various heuristic algorithms. Genome sequencing based on a combination of this method and gel sequencing techniques may be significantly more economical than gel methods alone.

Bacteriophage M13↗

PubMed2006

Pinhole SPECT imaging: compact projection/backprojection operator for efficient algebraic reconstruction.

We describe the efficient algebraic reconstruction (EAR) method, which applies to cone-beam tomographic reconstruction problems with a circular symmetry. Three independant steps/stages are presented, which use two symmetries and a factorization of the point spread functions (PSFs), each reducing computing times and eventually storage in memory or hard drive. In the case of pinhole single photon emission computed tomography (SPECT), we show how the EAR method can incorporate most of the physical and geometrical effects which change the PSF compared to the Dirac function assumed in analytical methods, thus showing improvements on reconstructed images. We also compare results obtained by the EAR method with a cubic grid implementation of an algebraic method and modeling of the PSF and we show that there is no significant loss of quality, despite the use of a noncubic grid for voxels in the EAR method. Data from a phantom, reconstructed with the EAR method, demonstrate 1.08-mm spatial tomographic resolution despite the use of a 1.5-mm pinhole SPECT device and several applications in rat and mouse imaging are shown. Finally, we discuss the conditions of application of the method when symmetries are broken, by considering the different parameters of the calibration and nonsymmetric physical effects such as attenuation.

Algorithms↗

PubMed2005

Implantation of radio frequency identification device (RFID) microchip in disaster victim identification (DVI).

The tsunami catastrophe of December 2004 left more than 200,000 dead. Disaster victim identification (DVI) teams were presented with the unprecedented challenge of identifying thousands of mostly markedly putrefied and partially skeletised bodies. To this end, an adequate body tagging method is essential. Conventional body bag tagging in terms of writing on body bags and placing of tags inside body bags proved unsatisfactory and problem prone due to consequences of cold storage, formalin (formaldehyde) embalming and body numbers inside storage facilities. The placement of radio frequency identification device (RFID) microchips inside victim bodies provided a practical solution to problems of body tagging and attribution in the DVI setting encountered by the Austrian DVI team in Thailand in early 2005.

Austria↗

PubMed1995

Using a pen-based computer to collect health-related quality of life and utilities information.

We have developed a system that uses the Newton MessagePad technology as part of a client-client-server paradigm to collect health-related quality of life information from breast cancer patients attending an outpatient clinic at the Dana-Farber Cancer Institute. Patients are asked to fill out an electronic questionnaire on the Newton, which then uploads the information into the institution's Oracle database. The program consists of a separate questionnaire engine and question base, facilitating questionnaire design and allowing us to give different questionnaires to different patients dynamically. The results of a preliminary trial show excellent user-acceptance of the device. Finally, we present a general framework for such systems and discuss issues that developers must consider when implementing a pen-based computer project.

Adult↗

PubMedDate not supplied

Some approaches to medical support for Martian expedition.

Medical support in a Martian expedition will be within the scope of crew responsibilities and maximally autonomous. Requirements to the system of diagnostics in this mission include considerable use of means and methods of visualization of the main physiological parameters, telemedicine, broad usage of biochemical analyses (including "dry" chemistry), computerized collection, measurement, analysis and storage of medical information. The countermeasure system will be based on objective methods of crew fitness and working ability evaluation, individual selection of training regimens, and intensive use of computer controlled training. Implementation of the above principles implies modernization and refinement of the countermeasures currently used by space crews of long-term missions (LTM), and increases of the assortment of active and passive training devices, among them a short-arm centrifuge. The system of medical care with the functions of prevention, clinical diagnostics and timely treatment will be autonomous, too. The general requirements to medical care during the future mission are the following: availability of conditions and means for autonomous urgent and special medical aid and treatment of the most possible states and diseases, "a hospital", and assignment to the crew of one or two doctors. To ensure independence of medical support and medical care in an expedition to Mars an automated expert system needs to be designed and constructed to control the medical situation as a whole.

Adaptation, Physiological↗

PubMed2006

Orthogonal frequency coding for SAW tagging and sensors.

Surface acoustic wave (SAW)-based sensors can offer wireless, passive operation in numerous environments, and various device embodiments are used for retrieval of the sensed data information. Single sensor systems typically can use a single carrier frequency and a simple device embodiment because tagging is not required. In a multisensor environment, it is necessary to both identify the sensor and retrieve the sensed information. This paper presents the concept of orthogonal frequency coding (OFC) for applications to SAW sensor technology. The OFC offers all advantages inherent to spread spectrum communications, including enhanced processing gain and lower interrogation power spectral density (PSD). It is shown that the time ambiguity in the OFC compressed pulse is significantly reduced as compared with a single frequency tag having the same code length, and additional coding can be added using a pseudo-noise (PN) sequence. The OFC approach is general and should be applicable to many differing SAW sensors for temperature, pressure, liquid, gases, etc. Device embodiments are shown, and a potential transceiver is described. Measured device results are presented and compared with coupling of modes (COM) model predictions to demonstrate performance. Devices then are used in computer simulations of the proposed transceiver design, and the results of an OFC sensor system are discussed.

Computer-Aided Design↗

PubMed2003

Ancient Wings: animating the evolution of butterfly wing patterns.

Character optimization methods can be used to reconstruct ancestral states at the internal nodes of phylogenetic trees. However, seldom are these ancestral states visualized collectively. Ancient Wings is a computer program that provides a novel method of visualizing the evolution of several morphological traits simultaneously. It allows users to visualize how the ventral hindwing pattern of 54 butterflies in the genus Bicyclus may have changed over time. By clicking on each of the nodes within the evolutionary tree, the user can see an animation of how wing size, eyespot size, and eyespot position relative the wing margin, have putatively evolved as a collective whole. Ancient Wings may be used as a pedagogical device as well as a research tool for hypothesis-generation in the fields of evolutionary, ecological, and developmental biology.

Animals↗

PubMed2004

In vitro evaluation of normal and abnormal lungs with ultra-high-resolution CT.

Synchrotron radiation microtomography is a new technique with high directionality of a synchrotron radiation beam and a high-resolution detector array. In this study, we estimated the visualization of the peripheral human lung structure with an ultra-high-resolution computed tomography (CT) system, the synchrotron radiation CT. The synchrotron radiation CT system uses the bending magnet beamline emitted from the 8.0 GeV electron storage ring. Six lung specimens were obtained at autopsy: 3 normal, 1 cellular alveolitis, 1 diffuse alveolar damage, and 1 pulmonary hemorrhage. Each specimen was cut down to a cylindrical sample with 6-mm diameter and 15- to 25-mm height. The synchrotron radiation CT images of these lung samples were obtained using the ultra-high-resolution image detector system with a charge coupled device (CCD) array detector (1024 x 1024 pixels with 12 x 12 microm2 pixel size). After that, the sample specimens were sliced to 200 microm (micrometer) thickness, and were observed with a stereomicroscope and by contact radiography. Finally, approximately 10-microm thick microscopic images were obtained and compared with the synchrotron radiation CT images. The synchrotron radiation CT could depict the peripheral lung including peripheral airways, airspaces, and alveolar walls individually. Each finding in the 3 disease processes seen on the synchrotron radiation CT images correlated well with the microscopic findings. The synchrotron radiation CT allows microtomographic imaging of human lung specimens with ultra high-spatial resolution (12 microm) on a level approaching that of conventional histopathology, without sectioning.

Humans↗

PubMed1990

Use of a piezoelectric film sensor for monitoring vascular grafts.

Detection of failing arterial reconstructions requires intensive surveillance by frequent physical examination and noninvasive laboratory testing. However, many grafts fail during the intervals between these examinations. For this reason, we have developed an implantable miniaturized piezoelectric flow detection device whose function can be monitored externally by radiotransmission across the skin. Sensors were constructed from ultrathin polyvinylidene fluoride (PVF2) with piezoelectric activity and attached with silicone fixative to 6-mm polytetrafluoroethylene grafts. Ten of these grafts were placed in mongrel dogs as iliofemoral bypasses. Real time data were acquired from the sensors at a rate of 200 Hz, using a DATAQ A/D data acquisition board and CODAS data acquisition software, while simultaneous blood flow (using an electromagnetic flowmeter) and intraluminal pressure were processed by using separate channels of the same data acquisition board. The data were stored on computer storage media and analyzed by the ASYST software, which allows simultaneous signal curves to be compared using regression analysis. In the resting state, the mean blood flow was 123 +/- 16 mL and the mean intraluminal pressure was 124/78 mm Hg, and there was perfect correlation between the PVF2 sensor and the flowmeter and between the sensor and the intraluminal pressure (correlation coefficient, r greater than or equal to 0.99 and r greater than or equal to 0.93, respectively). A tourniquet was applied to the iliac artery proximal to the graft to reduce the flow to approximately half of the resting state (mean flow after tourniquet: 66 +/- 6 mL/minute). Signal tracings from the three sources showed a remarkable similarity with a very high correlation coefficient (r greater than or equal to 0.99 between sensor and flowmeter and r greater than or equal to 0.92 between sensor and the pressure signal). These preliminary results show that the sensors made from low-profile and low-mass PVF2 material have the potential of being implanted around grafts for long-term, continuous monitoring of graft function. Further studies involving long-term implantation to assess the effect of tissue ingrowth and loss of compliance are necessary before this device can be used clinically.

Animals↗

PubMed1997

Simultaneous digitization of upper airway fiber-optic images and respiratory signals.

We developed an inexpensive and efficient method for simultaneously digitizing respiratory signals and fiber-optic images of the upper airway. The main components of the system are a fiber-optic scope, a charge coupled device video camera, and a personal computer equipped with a frame grabber and an A/D board. The frame grabber digitizes images at five frames per second while the A/D board samples six respiratory signals at 25 samples per second. Digitized images are saved only in the event that the user instructs the computer to do so in order to limit disk space requirements. A circular buffering technique provides continuous storage of the most recent 50 frames in frame grabber memory. This feature gives the user up to 10 seconds, following the beginning of a respiratory event, to initiate the saving of images to computer hard disk. A postacquisition program displays the data acquired during the sleep study and allows the user to interactively select images for subsequent upper airway area measurement. This system enables us to observe and quantify the dynamics of the upper airway during different breathing conditions with minimal time and cost. It is also a potential clinical tool to use to determine the site of obstruction during sleep in patients with obstructive sleep apnea.

Computers↗

PubMed1995

Computed dental radiography: evaluation of a new charge-coupled device-based intraoral radiographic system.

Computed dental radiography is a filmless system of dental x-ray imaging. It features multiple sensors with receptive areas and image quality that approach the size and resolution of film. The system is able to match the utility of film on levels such as multiple-sized images and printing output. It approaches film in quality of image and diagnostic capacity. In features such as speed of image acquisition, reduction in radiation dose, retrieval of data, and organization and storage of images, the computed dental radiography system surpasses traditional x-ray film.

Evaluation Studies as Topic↗

PubMed2004

Integrating context-aware public displays into a mobile hospital information system.

Hospitals are convenient settings for deployment of ubiquitous computing technology. Not only are they technology-rich environments, but their workers experience a high level of mobility resulting in information infrastructures with artifacts distributed throughout the premises. Hospital information systems (HISs) that provide access to electronic patient records are a step in the direction of providing accurate and timely information to hospital staff in support of adequate decision-making. This has motivated the introduction of mobile computing technology in hospitals based on designs which respond to their particular conditions and demands. Among those conditions is the fact that worker mobility does not exclude the need for having shared information artifacts particular locations. In this paper, we extend a handheld-based mobile HIS with ubiquitous computing technology and describe how public displays are integrated with handheld and the services offered by these devices. Public displays become aware of the presence of physicians and nurses in their vicinity and adapt to provide users with personalized, relevant information. An agent-based architecture allows the integration of proactive components that offer information relevant to the case at hand, either from medical guidelines or previous similar cases.

Artificial Intelligence↗

PubMed1997

Low-cost automatic activity data recording system.

We describe a low-cost, high quality device capable of monitoring indirect activity by detecting touch-release events on a conducting surface, i.e., the animal's cage cover. In addition to the detecting sensor itself, the system includes an IBM PC interface for prompt data storage. The hardware/software design, while serving for other purposes, is used to record the circadian activity rhythm pattern of rats with time in an automated computerized fashion using minimal cost computer equipment (IBM PC XT). Once the sensor detects a touch-release action of the rat in the upper portion of the cage, the interface sends a command to the PC which records the time (hours-minutes-seconds) when the activity occurred. As a result, the computer builds up several files (one per detector/sensor) containing a time list of all recorded events. Data can be visualized in terms of actograms, indicating the number of detections per hour, and analyzed by mathematical tools such as Fast Fourier Transform (FFT) or cosinor. In order to demonstrate method validation, an experiment was conducted on 8 Wistar rats under 12/12-h light/dark cycle conditions (lights on at 7:00 a.m.). Results show a biological validation of the method since it detected the presence of circadian activity rhythm patterns in the behavior of the rats.

Animals↗

PubMedDate not supplied

Clinician use of a palmtop drug reference guide.

OBJECTIVE: Problems involving drug knowledge are one of the most common causes of serious medication errors. Although the information that clinicians need is often available somewhere, retrieving it expeditiously has been problematic. At the same time, clinicians are faced with an ever-expanding pharmacology knowledge base. Recently, point-of-care technology has become more widely available and more practical with the advent of handheld, or palmtop, computing. Therefore, the authors evaluated the clinical contribution of a drug database developed for the handheld computer. ePocrates Rx (formerly known as qRx; ePocrates, San Carlos, California) is a comprehensive drug information guide that is downloadable free from the Internet and designed for the Palm OS platform align="right". DESIGN: A seven-day online survey of 3,000 randomly selected ePocrates Rx users was conducted during March 2000. MEASUREMENTS: User technology experience, product evaluation and usage patterns, and the effects of the drug reference database on information-seeking behavior, practice efficiency, decision making, and patient care. RESULTS: The survey response rate was 32 percent (n=946). Physicians reported that ePocrates Rx saves time during information retrieval, is easily incorporated into their usual workflow, and improves drug-related decision making. They also felt that it reduced the rate of preventable adverse drug events. CONCLUSIONS: Self-reported perceptions by responding clinicians endorse improved access to drug information and improved practice efficiency associated with the use of handheld devices. The clinical and practical value of using these devices in clinical settings will clearly grow further as wireless communication becomes more ubiquitous and as more applications become available.

Attitude to Computers↗

PubMed2002

[Research on slit lamp bio-microscope image analysis system].

Slit lamp bio-microscope image analysis system can provide objective and quantitative diagnosis evidences for ophthalmologists and make available efficient storing, management and intercourse of sufferer information and diagnosis results. In this paper, the system is discussed on its devices, software structure, analysis process and algorithm.

Algorithms↗

PubMed1995

Development of a personal computer's viewing station for the IS&C magneto-optical disk.

We developed a display station for the medical images stored in the IS&C (Image Save and Carry) magneto-optical disk. This station consisted of the personal computer and the magneto-optical disk drive. The performance of this system was evaluated and was compared with the Unix workstations. We found that the personal computer system had an adequate ability to display medical images. It provided, moreover, for portability and practical use of medical information.

Data Display↗

PubMed2005

Reagent-loaded cartridges for valveless and automated fluid delivery in microfluidic devices.

An important problem in the life sciences and in health care is simple and rapid detection of biomarkers. Although microfluidic devices are potentially useful in addressing this problem, current techniques for automating fluid delivery--which include valves and electroosmosis--require sophisticated microfabrication of the chip, bulky instrumentation, or both. In this paper, we describe a simple and reliable technique for storing and delivering a sequence of reagents to a microfluidic device. The technique is low-cost, requires minimal user intervention, and can be performed in resource-poor settings (e.g., outside of a laboratory) in the absence of electricity and computer-controlled equipment. In this method, cartridges made of commercially available tubing are filled by sequentially injecting plugs of reagents separated by air spacers. The air spacers prevent the reagents from mixing with each other during cartridge preparation, storage, and usage. As an example, we used this "plug-in cartridge" technology to complete a solid-phase immunoassay in a microchannel in 2 min with low-nanomolar sensitivity and demonstrate the diagnosis of HIV in 13 min.

Acquired Immunodeficiency Syndrome↗