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PubMed1991

[The epidemiology of congenital defects in central nervous system development in children].

The prevalence and structure as well as risk factors for congenital developmental abnormalities (CDA) of the central nervous system (CNS) have been studied over recent 17 years among the newborn's population (217,000 births) and 7,845 dead children of varying age. The stage I work involved a retrospective analysis of the medical documentation up to broad-scale introduction of ultrasonography (US) of fetal abnormalities during pregnancy, the stage II work consisted in an analysis of the genetic monitoring after the introduction of US of the fetal states, comprising the pregnant, which approximated 98%. The significant risk factors for CDA of the CNS were the pregnancy rate (the IV and consequent ones), some types of pregnancy pathology (toxemia of the first half of pregnancy, infectious diseases) as well as prematurity, intrauterine hypotrophy, previous exposures of the mother and father of the future child to ionizing radiation. Over the recent years a stable tendency has been noted toward decrease of both the prevalence of CDA of the CNS among the newborn and dead children and of anencephalies and hydrocephalus, the developmental abnormalities most clearly diagnosed on US.

Brain↗
PubMed2003

[Routine monitoring of congenital defects in children in the Czech Republic. History and present status].

OBJECTIVE: Analysis of quarterly incidences of selected types of birth defects in the Czech Republic in 1994-2000. SETTING: Institute for the Care of Mother and Child, Prague; Department of Medical Genetics, Thomayer Hospital, Prague and Institute of Health Information and Statistics, Prague. TYPE OF STUDY: Retrospective analysis of quarterly data from registers of birth defects in the Czech Republic. METHODS: Processing and analysis of incidences of selected birth defects in the Czech Republic in relative numbers (per 10,000 liveborn infants). The ratio of observed/expected values was calculated. RESULTS: During the period between Jan. 1 1994 and Dec. 31 2000 a total of 654 695 liveborn infants were born (for 2000 preliminary data). This number included 18,008 infants with one or more birth defects. The mean incidence of all cases during the observation period was 262.99 per 10,000 liveborn infants. In the analysis the authors discuss in detail also the frequency and its changes of eleven selected types of birth defects. CONCLUSION: Continuous registration and analysis of the incidence of inborn defects are essential as the basis for evaluation of the influence of the mentioned factors on the incidence of inborn defects.

Congenital Abnormalities↗