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Bedside evaluation of learning and memory: descriptive information on a shortened version of the Luria Memory Words Test.

Descriptive information on the shortened version of the Luria Memory Words Test (LMWT-SF), a serial word-learning list of seven items, administered across five trials with a three-minute delay, is presented. The purpose of the investigation was to determine what constituted adequate performance among nondemented elderly inpatients, and to compare the results to traditional bedside memory measures among elders diagnosed with dementia. Results revealed significant group differences on Trials 3, 4, 5, total learning score, and the delay trial among demented and non-demented geriatric inpatients. Sensitivity and specificity ratings for the LMWT-SF delay trial were 80% and 72%, respectively, at a cut-off of 3 / 4, and 71% and 60%, respectively, for the total learning score, at a cut-off of 26 / 27. While this measure cannot take the place of a comprehensive evaluation of memory and learning, LMWT-SF performance can suggest when a more comprehensive evaluation is required, and may provide value as a cost-effective screening tool.

Aged↗

The influence of grammatical, local, and organizational redundancy on implicit learning: an analysis using information theory.

People behave as if they know the structure of their environment. Because people rarely study that structure explicitly, several theorists have postulated an implicit learning system that abstracts that structure automatically. An alternative view is that people respond to local structure that derives from global structure. Measures are developed that quantify structure in a set of stimuli, in individual stimuli, and in encoded stimuli. The authors apply the measures to examine serial recall for sequences of colors generated using a stationary Markov grammar. They demonstrate that the 3 kinds of redundancy are confounded and show that the memorial advantage for grammatical stimuli reflects participants' use of local expressions of grammatical structure to aid learning.

Humans↗

Changes in spontaneous EEG activity indicate a special kind of information processing in concept learning.

Some findings in the literature suggest that a high amount of spectral power in spontaneous EEG alpha 1 band (7.5-10.0 Hz) may be associated with tasks demanding extensive monitoring of stimulus information and combining features for a match with internal concepts ("exploration"). EEG recordings were obtained from 9 subjects involved in a concept-learning task. They had to match visually presented objects with a concept built up by hypothesis and to respond by pressing a "yes" or "no" key. Epochs of EEG data were analyzed with epoch center-times at 500 and 250 ms before response execution. In the case of "yes" responses, when subjects could match their hypothesis positively with combined features of the presented object increased alpha 1 spectral power was found. Also alpha 1 power was larger immediately after disconfirming feedback than after confirming feedback. Additionally, alpha 2 spectral power (10.5-12.5 Hz) was found to be larger 250 ms after confirming feedback than after disconfirming feedback. It is argued that alpha 1 power seems to reflect those mental processes which are involving in combining features and matching them to a concept in mind. The increase in alpha 2 power after confirming feedback is interpreted in terms of general processing demands imposed during task performance.

Adult↗

Reading level, learning presentation preference, and desire for information among cancer patients.

BACKGROUND AND METHODS: Cancer patients may face a number of obstacles to learning, including complexity of information, inappropriateness of timing and method of presentation, avoidance as a way of coping, and inability to read. Patients' reading levels, preferred learning methods, and desires for information and the usefulness of two instruments in a clinical setting were investigated. One instrument provided information about sociodemographics, desire for information, and learning preferences; the second instrument, the Rapid Estimate of Adult Literacy in Medicine (REALM), assessed reading ability. RESULTS: The 63 patients studied, most of whom were African American, wanted all available information (90%), desired participation in care decisions (68%), and preferred personal interactive learning (77%). The REALM mean score was 50.8, indicating a seventh-to-eighth-grade reading level. Over half read below their stated educational levels and would be unable to read most available patient education materials. CONCLUSIONS: Educational level did not indicate reading ability; the patients could state their desires for information and their learning preferences, and the REALM was easy to use.

Adult↗

Disorientation in amnesia. A confusion of memory traces.

Disorientation is a common phenomenon in delirium and amnesia. It is thought to have an obvious explanation, i.e. disoriented patients fail to store the information crucial for the maintenance of orientation. In this study, we explored whether disorientation was indeed associated with a failure to learn new information or rather with a confusion of information within memory. Twenty-one patients with severe amnesia were examined. Orientation was tested with a 20-item questionnaire. Two runs of a continuous recognition task were used to test the ability to acquire information (first run of the task) and the tendency to confuse the temporal context of information acquisition (comparison of the second with the first run). We found that orientation was much better predicted by the measure of temporal context confusion (r = 0.90) than by the ability to simply acquire information (r = 0.54). Superimposition of neuroradiological scans demonstrated that increased temporal context confusion was associated with medial orbitofrontal or basal forebrain damage; patients with normal levels of temporal context confusion did not have damage to these areas. We conclude that disorientation more often indicates a confusion of memory traces from different events, i.e. increased temporal context confusion, than an inability to learn new information. Disorientation appears to reflect primarily a failure of the orbitofrontal contribution to memory.

Adult↗

A neural model of cortico-cerebellar interactions during attentive imitation and predictive learning of sequential handwriting movements.

Much sensory-motor behavior develops through imitation, as during the learning of handwriting by children. Such complex sequential acts are broken down into distinct motor control synergies, or muscle groups, whose activities overlap in time to generate continuous, curved movements that obey an inverse relation between curvature and speed. How are such complex movements learned through attentive imitation? Novel movements may be made as a series of distinct segments, but a practiced movement can be made smoothly, with a continuous, often bell-shaped, velocity profile. How does learning of complex movements transform reactive imitation into predictive, automatic performance? A neural model is developed which suggests how parietal and motor cortical mechanisms, such as difference vector encoding, interact with adaptively timed, predictive cerebellar learning during movement imitation and predictive performance. To initiate movement, visual attention shifts along the shape to be imitated and generates vector movement using motor cortical cells. During such an imitative movement, cerebellar Purkinje cells with a spectrum of delayed response profiles sample and learn the changing directional information and, in turn, send that learned information back to the cortex and eventually to the muscle synergies involved. If the imitative movement deviates from an attentional focus around a shape to be imitated, the visual system shifts attention, and may make an eye movement, back to the shape, thereby providing corrective directional information to the arm movement system. This imitative movement cycle repeats until the cortico-cerebellar system can accurately drive the movement based on memory alone. A cortical working memory buffer transiently stores the cerebellar output and releases it at a variable rate, allowing speed scaling of learned movements which is limited by the rate of cerebellar memory readout. Movements can be learned at variable speeds if the density of the spectrum of delayed cellular responses in the cerebellum varies with speed. Learning at slower speeds facilitates learning at faster speeds. Size can be varied after learning while keeping the movement duration constant (isochrony). Context-effects arise from the overlap of cerebellar memory outputs. The model is used to simulate key psychophysical and neural data about learning to make curved movements, including a decrease in writing time as learning progresses; generation of unimodal, bell-shaped velocity profiles for each movement synergy; size and speed scaling with preservation of the letter shape and the shapes of the velocity profiles; an inverse relation between curvature and tangential velocity; and a Two-Thirds Power Law relation between angular velocity and curvature.

Attention↗

Acquisition of incidental information during instruction for a response-chain skill.

We examined the acquisition of incidental information and observational learning of incidental information by adolescents with moderate intellectual disabilities during school-directed systematic instruction. Effectiveness of constant time-delay instruction for vocational-skill acquisition was evaluated within a multiple-probe design across six dyads. Dyadic instructional arrangements allowed the assessment of incidental information acquired through observation. The constant time-delay procedure was effective in teaching the target vocational skill. In addition, participants acquired and retained approximately 50% of the incidental information to which they were exposed during the consequent events of constant time-delay instruction either through direct verbal presentation or through observation of their peers' instruction.

Adolescent↗

Family physicians' knowledge of malignant melanoma.

BACKGROUND: The incidence and mortality of melanoma have been increasing during the past two decades. Melanoma is relatively easy to detect and, when diagnosed early, is curable. OBJECTIVE: Our purpose was to assess the baseline knowledge of malignant melanoma among family practitioners and to identify their preferred method of learning new information about the skin. METHODS: The design was a randomized survey by mailed questionnaire. RESULTS: More than 50% of physicians stated they lacked confidence in being able to recognize melanoma. Family physicians were well informed on factors affecting prognosis, but knowledge deficits were identified on history, physical examination, and risk factors. The most effective method of learning new information about the skin was hands-on teaching demonstration. CONCLUSION: Many family physicians are not confident in their ability to recognize melanoma, and knowledge deficits were identified. In addition, some important risk factors were not well recognized. Thus, those at highest risk may not be receiving education on early detection that may help decrease the incidence and mortality of melanoma.

Adult↗

When can a lack of structure facilitate strategic processing of information?

BACKGROUND: Researchers examining the effectiveness of an elaboration strategy (answering 'why') for learning new information have been concerned with the familiarity of the materials and how that affects learning. It may be, however, that both how information is organised and familiarity impact on the potency of the strategy. AIMS: We examined the influence of presentation structures (i.e., organisation of information) on the effectiveness of an elaboration strategy. SAMPLES: All participants were undergraduates (78 females, 67 males) enrolled in a first-year psychology course. Fifteen students participated in Experiment One, 42 students in Experiment Two, and 88 students in Experiment Three. METHODS: In Experiment One, preference for conceptual organisation was assessed. In Experiments Two and Three, students answered 'why' questions when different presentation structures were used. RESULTS: Students' preferred method of organisation did not match the imposed structure found in past research, suggesting that students may have been restricted in their ability to process the information distinctively. Students who were presented with the information in a random order achieved the largest memory scores. CONCLUSIONS: When students have to reconstruct as well as encode the information, these added task demands provide an added benefit for learning.

Adult↗

Using information from databases to improve clinical practice: lessons learned under fire.

BACKGROUND: Information derived from a clinical database can be used to produce reports with valid, applicable data, to assemble outcomes data for purposes of marketing or practice survival, and to improve and optimize patient care. METHODS: In response to lay-press figures suggesting a high risk-adjusted mortality at St. Peter's Hospital (Albany, NY), a multidisciplinary group at the hospital undertook a collaborative review of information from our clinical database to identify any patterns that could explain this disturbing summary statistic. RESULTS: This review showed that for the vast majority (> 95%) of cases mortality was on a par with or lower than the statewide average. The elevated mortality was confined to a small and specific subset of high-risk patients. Once identified, attention was focused on this group of patients, and both cardiologists and surgeons discussed practice changes based on information from the clinical database. Since program changes were instituted in 1993, mortality has decreased in both high-risk and all other patients. Overall mortality for coronary artery bypass graft patients has decreased from 4.5% to about 1.5%. CONCLUSIONS: Use of a database to extract a single number reflecting patient-care performance, eg, short-term mortality, can conceal more information than it conveys. Only in-depth analysis of the information in the database can identify areas for improvement in clinical practice.

Coronary Artery Bypass↗

An incremental learning algorithm with confidence estimation for automated identification of NDE signals.

An incremental learning algorithm is introduced for learning new information from additional data that may later become available, after a classifier has already been trained using a previously available database. The proposed algorithm is capable of incrementally learning new information without forgetting previously acquired knowledge and without requiring access to the original database, even when new data include examples of previously unseen classes. Scenarios requiring such a learning algorithm are encountered often in nondestructive evaluation (NDE) in which large volumes of data are collected in batches over a period of time, and new defect types may become available in subsequent databases. The algorithm, named Learn++, takes advantage of synergistic generalization performance of an ensemble of classifiers in which each classifier is trained with a strategically chosen subset of the training databases that subsequently become available. The ensemble of classifiers then is combined through a weighted majority voting procedure. Learn++ is independent of the specific classifier(s) comprising the ensemble, and hence may be used with any supervised learning algorithm. The voting procedure also allows Learn++ to estimate the confidence in its own decision. We present the algorithm and its promising results on two separate ultrasonic weld inspection applications.

Journal Article↗

Informative structure priors: joint learning of dynamic regulatory networks from multiple types of data.

We present a method for jointly learning dynamic models of transcriptional regulatory networks from gene expression data and transcription factor binding location data. Models are automatically learned using dynamic Bayesian network inference algorithms; joint learning is accomplished by incorporating evidence from gene expression data through the likelihood, and from transcription factor binding location data through the prior. We propose a new informative structure prior with two advantages. First, the prior incorporates evidence from location data probabilistically, allowing it to be weighed against evidence from expression data. Second, the prior takes on a factorable form that is computationally efficient when learning dynamic regulatory networks. Results obtained from both simulated and experimental data from the yeast cell cycle demonstrate that this joint learning algorithm can recover dynamic regulatory networks from multiple types of data that are more accurate than those recovered from each type of data in isolation.

Bayes Theorem↗

Information skills for distance learning.

In spring 1997, the Education Services department at the University of North Carolina at Chapel Hill (UNC-CH) Health Sciences Library (HSL) developed six Web-based tutorials designed to teach information skills. This paper describes how the modules were created.

Academic Medical Centers↗

Practical strategies for working with indigenous people living in Queensland, Australia.

Internationally, occupational therapists have recognized the need to provide culturally appropriate services for indigenous people. This study explored experiences, perspectives and practical strategies of occupational therapists working with Aboriginal and Torres Strait Islander people living in rural and remote areas of Queensland, Australia. Semi-structured interviews were conducted with eight occupational therapists who had at least 12 months' experience providing services to Aboriginal and Torres Strait Islander people in health, rehabilitation or education services. Key themes identified in the data focused on strategies for facilitating effective communication with individuals and families, and collaborating with other service providers. The role of Aboriginal Liaison Officers or Indigenous Health Workers was emphasized by participating therapists. Participants identified resources that they perceived as useful in their practice, such as cross-cultural training and access to indigenous health workers. Other resources suggested for further development included information about learning styles of indigenous people and information about cultural variations between specific Aboriginal and Torres Strait Islander communities. The small number of participants limits generalizability of the findings. However, therapists can decide on the relevance of strategies to their own workplaces. Suggestions for further research focused on improving occupational therapy services for indigenous people in Australia. These include an investigation of therapy goals with indigenous people, and interviews with indigenous Australians and indigenous health workers about their experiences and perceptions of occupational therapy.

Culture↗

Learning myopia: an adaptive recency effect in category learning.

Recency effects (REs) have been well established in memory and probability learning paradigms but have received little attention in category earning research. Extant categorization models predict REs to be unaffected by learning, whereas a functional interpretation of REs, suggested by results in other domains, predicts that people are able to learn sequential dependencies and incorporate this information into their responses. These contrasting predictions were tested in 2 experiments involving a classification task in which outcome sequences were autocorrelated. Experiment 1 showed that reliance on recent outcomes adapts to the structure of the task, in contrast to models' predictions. Experiment 2 provided constraints on how sequential information is learned and suggested possible extensions to current models to account for this learning.

Attention↗

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

PDAPP transgenic mice overexpress a mutant form of human amyloid precursor protein under control of the platelet-derived growth factor promoter in CNS neurons that causes early onset, familial Alzheimer's disease in humans. These mice, on a mixed genetic background, have been shown to have substantial learning impairments from early ages, as well as an age-dependent decline in learning ability that has been hypothesized to be caused by amyloid-beta (Abeta) accumulation. The goals of this study were to determine: (1) whether PDAPP mice on a pure C57BL/6 background develop more severe age-dependent learning deficits than wild-type mice; (2) if so, whether Abeta accumulation accounts for the excessive decline in learning ability; and (3) whether the learning deficits are reversible, even after significant Abeta deposition. At 4-6, 10-12, or 17-19 months of age, PDAPP and littermate wild-type mice on a C57BL/6 background were tested on a 5 week water maze protocol in which the location of the escape platform changed weekly, requiring the mice to repeatedly learn new information. PDAPP mice exhibited impaired spatial learning as early as 4 months (pre-Abeta deposition), and the performance of both wild-type and PDAPP mice declined with age. However, PDAPP mice exhibited significantly greater deterioration with age. Direct evidence for the role of Abeta accumulation in the age-related worsening in PDAPP mice was provided by the observation that systemic treatment over several weeks with the anti-Abeta antibody 10D5 reduced plaque deposition, increased plasma Abeta, improved hippocampal long-term potentiation, and improved behavioral performance in aged PDAPP mice with substantial Abeta burden.

Amyloid beta-Protein Precursor↗