[Experimental and clinical basis for lymphotropic antibiotic therapy in surgery].
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The article describes the morphological basis of the positive effect of the treatment of experimental pancreonecrosis, reproduced on dogs, by single endolymphatic injection of 5- fluorouracil. The index of the enzymatic activity in the pancreas correlated with the morphological data.
The erysipelatous inflammation is characterized by a persistent course, tendency to increase of complicated forms, often followed by cases of the development of elephantiasis and frequent recidivations. The method of scraping of the epidermis is thought to be most informative. The complex treatment should include endolymphatic injections of antibiotics which is found to shorten the period of treatment and reduce the amount of recurrences.
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Enteral, intramuscular or intravenous antibiotic therapy is the basic current method of treating acute inflammatory diseases of the scrotum. However, the efficacy of the treatment is not always sufficient. A new endolymphatic method of antibiotic administration is discussed. Its high efficacy is shown. The method provides a more rapid clinical recovery and decreases the number of complications. A history of a patient given a treatment course with endolymphatic administration of the antibiotic is presented. Endolymphatic administration of antibiotics is recommended as the main method of antibiotic therapy in treatment of patients with acute inflammatory diseases of the scrotum.
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Endolymphatic infusions of an antibacterial complex (antibiotic--lysozyme--proteinase inhibitor) resulted in recovery of 92,6% of patients after a complex treatment of diffuse peritonitis and sepsis. Gauze-sorbent tampons used in empyema of pleura give rapid cleaning of the cavity walls from pyo-necrotic masses and decreased the activity of the inflammatory process.
Based on a study of the clinical efficacy of endolymphatic administration of antibiotics in 160 patients with different pulmonary diseases the methods of the use of endolymphatic therapy (ET) as part of a complex of therapeutic measures for lung abscess, pneumonia, chronic purulent bronchitis have been devised. The pharmacodynamics of gentamicin, brulamicin, pentrexyl, ketocef and claforan administered endolymphatically has been explored. Positive shifts have been demonstrated in cyclic nucleotides and immune responsiveness during ET, a constituent part of multiple modality treatment.
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