PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Intubation, Intratracheal”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25Linked to original sources
PubMed2003

Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase.

OBJECTIVE: To examine whether treatment of premature infants with intratracheal recombinant human CuZn superoxide dismutase (r-h CuZnSOD) reduces bronchopulmonary dysplasia and improves pulmonary outcome at 1 year corrected age. DESIGN: Three hundred two premature infants (600-1200 g birth weight) treated with exogenous surfactant at birth for respiratory distress syndrome were randomized to receive either intratracheal r-h CuZnSOD (5 mg/kg in 2 mL/kg saline) or placebo every 48 hours (as long as intubation was required) for up to 1 month of age. Short-term, as well as longer-term pulmonary outcome was assessed. RESULTS: There were no differences between groups in the incidence of death or the development of bronchopulmonary dysplasia (oxygen requirement with an Edwards chest radiograph score of >or=3) at 28 days of life or 36 weeks' postmenstrual age. r-h CuZnSOD was well-tolerated and not associated with significant increases in any adverse event. At a median of 1 year corrected age, health assessments and physical examinations were performed on 209 (80%) surviving infants, with complete data available on 189 infants. Thirty-seven percent of placebo-treated infants had repeated episodes of wheezing or other respiratory illness severe enough to require treatment with asthma medications such as bronchodilators and/or corticosteroids compared with 24% of r-h CuZnSOD-treated infants, a 36% reduction. In infants <27 weeks' gestation, 42% treated with placebo received asthma medications compared with 19% of r-h CuZnSOD-treated infants, a 55% decrease. Infants <27 weeks' gestation who received r-h CuZnSOD also had a 55% decrease in emergency department visits and a 44% decrease in subsequent hospitalizations. Growth measurements and the results of physical examinations were comparable between groups. CONCLUSIONS: These data indicate that treatment at birth with r-h CuZnSOD may reduce early pulmonary injury, resulting in improved clinical status when measured at 1 year corrected age. r-h CuZnSOD appears to be a safe and effective therapy that improves pulmonary outcome in high-risk premature infants.

Age Factors↗
PubMed1987

Effect of vehicular volume on the early pulmonary injury and inflammatory response in rats inoculated intratracheally with silica.

The effect of vehicular saline solution volume on early lesions induced in rats by intratracheal administration of silica was evaluated. Seventy-two male Long-Evans rats were randomly assigned 6 each to 12 factorial groups (3 X 2 X 2): 3 doses of silica (0, 2.5, and 5 mg), 2 volumes of vehicle (saline solution; 0.1 and 0.5 ml), and 2 postinoculation times (1 and 3 days). Lactate dehydrogenase and alkaline phosphatase activities in the bronchoalveolar lavage fluid supernatant and cell viability of bronchoalveolar cells were used as indicators of cell injury. The number of pulmonary alveolar macrophages and polymorphonuclear leukocytes were used as indicators of inflammatory response. Dose of silica and postinoculation time had a significant (P less than 0.05) effect on the biochemical and cellular composition of lavage fluid. The volume of vehicle in which silica was suspended significantly (P less than 0.05) enhanced the pulmonary injury and inflammatory response. However, dose-volume interaction was only significant (P less than 0.05) in 1 of 6 parameters, indicating that the effect was additive, but not synergistic, in nature. Seemingly, vehicle volume had an enhanced effect on the injury and the inflammatory response induced by intratracheal inoculation of silica.

Animals↗