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At least 451 records · Page 25Linked to original sources

PubMed2004

Unilateral gestational macromastia--a rare disorder.

Macromastia is the massive enlargement of the breast, unilateral or bilateral, disproportionate to the growth of the rest of the body. It is called gravid macromastia or gigantomastia of pregnancy when it occurs during pregnancy. It may or may not regress following parturition. Gestational macromastia is exceptionally rare. We report a 28-year-old female with gigantomastia of the left breast. She presented at four months post-partum with painful massive enlargement of the left breast since the third month of pregnancy. The overlying skin was stretched out and showed multiple ulcers with foul smelling discharge. The nipple and areola were unremarkable. Simple mastectomy was done, as fine needle aspiration cytology was suggestive of phylloides tumour. The breast specimen measured 30 x 30 x 9 cm and was replaced totally by grey-white tissue involving all the resection margins. No normal breast tissue or fat was identified. Histopathology showed periductal as well as diffuse fibrosis, adenosis and lactational changes. No features of phylloides tumour or carcinoma were present and it was diagnosed as unilateral gestational macromastia.

Adult↗

PubMed2006

Breast carcinoma with three coexistant type of metaplasia: sarcomatoid, giant cell and squamous differantiation.

We report on a women with metaplastic carcinoma of the right breast. After diagnosis she had a simple mastectomy operation. Pathological investigations were carried out on mastectomy material. Immunohistochemical analyses were performed. Bizarre, malignant giant cells and diffuse inflammatory reactions were predominantly noted. Sarcomatous metaplasia and rare squamous metaplasia were also seen. There was not any area of classic intraductal, invasive ductal, lobular or papillary carcinoma. The patient is still alive and well for more than five years. This uncommon case is described and discussed, and the related literature is reviewed.

Breast Neoplasms↗

PubMed1991

Phylloides tumours of the breast. A clinicopathologic study of 19 cases.

During a period of 29 years (1960-1989), 19 patients with benign (15 cases) or malignant (4 cases) phylloides tumours were seen at the Surgical Clinic of Fundeni Hospital. Fourteen patients were followed up for a period of 2 to 21 years (mean 9.3 years). Two patients with benign tumours developed malignant recurrences. The malignant potential could not be predicted by histologic criteria. Although 4 patients had malignant tumours and other 2 developed malignant recurrences later, no distant metastases and no death in the 14 patients available for follow up were observed. We believe that in large or malignant tumours simple mastectomy is the surgical treatment of choice, in most benign phylloides tumours a conservative approach (quadrantectomy or lumpectomy) may be considered of the patients can be adaquately followed up.

Adolescent↗

PubMed1991

Multiple, giant fibroadenoma.

Multiple, giant fibroadenomas are histologic and clinical variants of "juvenile" or "giant" fibroadenomas. These tumors are rare and occur mainly in adolescent and young adult black females. The individual lesions are well encapsulated with a histologic pattern primarily of the "juvenile" type, although cases of the "adult" type have been reported. A high incidence of recurrence is noted upon local excision, although this may decrease as the patient becomes older. Management options include local excision with reconstruction, reduction mammoplasty, and simple mastectomy with reconstruction. A case is described of this condition with review of the literature.

Adenofibroma↗

PubMed1975

Clinical course of cystosarcoma phyllodes related to histologic appearance.

A series of 17 females having cystosarcoma phyllodes underwent surgical treatment. The subsequent clinical course was observed periodically. Twelve patients had originally histologically benign tumors. Six patients had a recurrence, and of these, malignant characteristics developed in four instances. Five patients had originally histologically malignant tumors. Recurrences were encountered in four. Five patients died from a generalized spread of the tumor. Three of these patients had originally histologically benign tumors, in which malignant features of the recurrent tumor subsequently developed. The surgical treatment ranged from local excision to simple mastectomy with additional roentgenotherapy in three. Neither procedure prevented a recurrence from the original tumor, whether benign or malignant. Poor correlation exists between biologic behavior and histologic appearance of cystosarcoma phyllodes, independent of the surgical procedure. Wide local excision in histologically benign and mastectomy in histologically malignant tumors are advised, but no final decision could be reached. It is proposed to restrict ther term cystosarcoma phyllodes to histologically malignant tumors and use the term fibroadenoma phyllodes in instances of histologically benign tumors.

Breast Neoplasms↗

PubMed2006

Malignant peripheral nerve sheath tumor of breast in patient without Von Recklinghausen's neurofibromatosis: a case report.

Malignant peripheral nerve sheath tumor (MPNST) of the breast without Von Recklinghausen's neurofibromatosis (VRN) is extremely rare. The authors report a 19 year-old woman who presented with a 12 month history of a painless mass of the left breast. Tissue biopsy was performed. The histologic diagnosis was made with immunohistochemical study in which the tumor showed positivity of vimentin, S-100 protein, neuron-specific protein(NSE), neurofilament protein(NF) and glial fibrillary acidic protein(GFAP). The patient was referred for radiation therapy after simple mastectomy.

Adult↗

PubMed2006

Myxoid liposarcoma of the breast--report of a rare case.

Breast sarcomas are very rare. A 40 year old lady presented with a well-defined hard lump, 6 cm in size, in the left breast. Patient underwent simple mastectomy with axillary clearance following a diagnosis of phylloides tumour on fine needle aspiration cytology. Grossly, it was a circumscribed myxoid tumour. Histopathologically, it fulfilled all the criteria for a diagnosis of myxoid liposarcoma. The absence of epithelial component excluded phylloides tumour.

Adult↗

PubMed1975

[Definition and significance of carcinoma in situ of the breast gland].

1. Preinvasive phases of the cancer of the breast are observed with the intraductal cancers of the bigger ducts and with the so-called lobular carcinoma in situ. It shows, however, that the carcinoma of the ducts, above all the comedo-carcinoma, have to be considered as invasive cancers in more than 75%. These forms extend to the lobuli of the breast. 2. The Morbus Paget bases in one third on an intraductal preinvasive carcinoma, in two thirds on an invasive cancer. 3. This chapter deals with the differential diagnosis of the papilloma and papillary carcinoma. 4. Intralobular proliferations of the epithelium are observed at the periphery of undifferentiated cancers as secondary intraductal carcinoma and as primary lobular carcinoma. The so-called intralobular carcinoma in situ is in 15,2% followed by an invasive carcinoma after an interval of up to 28 years, and in 23% ipsilateral, in 9,5% contralateral. As therapy the subcutaneous or simple mastectomy is proposed.

Breast Neoplasms↗

PubMedDate not supplied

Effect of radiation on pulmonary functions in patients with breast cancer.

There is no systematic study available from our country regarding pulmonary function tests in patients of breast cancer who receive postoperative radiotherapy. Therefore, we planned a prospective study to find out the effect of radiation on pulmonary functions in patients with breast cancer; who had undergone surgery in the form of simple mastectomy and axillary clearance. Transient radiological changes were seen in two cases and one patient had fibrosis at 9 months.

Breast Neoplasms↗

PubMed1976

[Anatomical and clinical deliberations on the phyllodes tumor of the breast].

The authors report on three phyllod Tumours of the breast, two benign and one malignant conditions. They insist on the histological aspect of the tumour, underlining that in the benign forme both, epithelial and mesenchymal components does not present atypies, while in the malignant form only the mesenchymal component gets malign sarcomatous character. The microscopic aspect of the tumour and its clinical evolution are suspicious. The diagnosis can be specified only by the histopathological examination. The origin of the phyllod tumour is not clear and the authors discuss the possibility of its development upon a preexistent tumour, specifically on a fibroadenoma of the breast. The treatment is guided by the microscopic appearances. Generally they perform the ablation of the tumour when its dimensions are not greater then 10 cm. and the simple mastectomy when its diameter exceeds this dimension.

Adult↗

PubMed1991

A prospective study of patient choice in treatment for primary breast cancer.

One hundred and sixty-three patients with primary breast cancer were prospectively studied. Using recently developed selection criteria 91 patients were offered a choice of treatment. Forty-one chose to undergo conservation treatment and 47 chose to undergo simple mastectomy. In those women who were offered a choice of treatment there was a significant tendency for younger patients to choose breast conserving treatment.

Adult↗

PubMed1990

[The treatment of carcinoma in situ of the breast].

In reference to a series of 36 in situ breast carcinomas, the current therapeutic possibilities are considered: 8 lobular carcinomas in situ (LCIS) and 28 ductal carcinomas in situ (DCIS) were diagnosed between January 1985 and July 1988. These are infraclinical forms in 80% of the cases, representing 20% of the breast carcinomas treated during the same period of time. The natural history of carcinomas in situ is presented; LCIS rarely evolve toward an invasive carcinoma and they should not be considered as risk factors. DCIS evolve, after biopsy, toward an infiltrating ductal carcinoma in 26 to 28% of the cases. Axillary node invasion is present in 3% of the cases. After diagnostic biopsy of a LCIS, a subcutaneous mastectomy with prosthetic reconstruction will be offered only if there are bilateral foci or diffuse microcalcifications. Supervision will be recommended in all other cases. The results of the mastectomy-node excision procedure are well known for the LCIS: less than 5% recurrence and a mortality under 1.5%. The current tendency goes toward a limited surgical act: axillary dissection is discussed for small LCIS; lumpectomy is more and more advocated with long-term results still not well known; in case of lumpectomy, two prospective trials are currently in progress in the world, in order to assess the efficacy of radiotherapy.

Adult↗

PubMedDate not supplied

Cystosarcoma phyllodes: a clinicopathological analysis of 14 cases.

Experience with 14 cases of cystosarcoma phyllodes encountered at the 2nd Department of Propedeutic Surgery, Athens, University, between October, 1928 and December, 1978 is reported. Local excision including a wide cuff of uninvolved breast tissue is indicated for histologically proven benign and small tumors. For bulky or malignant tumors, a simple mastectomy is indicated. none of these neoplasms had metastasized to the axillary lymph nodes and, for this reason, and axillary node dissection was contraindicated.

Adolescent↗

PubMed1990

[Breast carcinoma metastasis to perineal neurofibroma].

A 51-year-old woman as admitted to our department because of multiple palpable tumors that were noted on the left breast, the perineum, and the neck, shoulders, arms, and legs. The breast tumor showed ulceration on the surface. The perineal tumor was 30 x 15 cm in size and had group slowly for 17 years. A chest X-ray revealed a bilateral coin lesion. She was diagnosed as having a left breast cancer with a skin lung metastasis and a perineal benign tumor. A simple mastectomy and a resection of the perineal tumor were performed. A postoperative examination revealed an adenocarcinoma of the breast and a fibroneurinoma of the perineum with a metastasis from the breast cancer.

Adenocarcinoma↗

PubMed1985

[Radiotherapy aspects in the treatment of breast cancer].

The role of radiotherapy in breast cancer has been to supply and complete radical or simple mastectomy, conservative surgery, and to improve quality of life in cases of disseminated disease. The concept of conservative surgery and radiation is based on successful treatment while preserving the breast. In randomized trials there were no significant differences in disease-free, distant-disease free or overall survival of patients treated by radical mastectomy or segmental mastectomy followed by breast irradiation. Adjuvant radiotherapy in treatment of operable breast cancer remains controversial, although most oncologists agree that it provides local and regional control of tumor. Preirradiation multidrug chemotherapy was added in inflammatory carcinoma of the breast, in patients with high risk of dissemination, and in gross local recurrences. Radiotherapy does relieve pain and disability caused by bone metastases in 80% and effective palliation is achieved by treatment of brain metastases.

Breast↗

PubMed1989

[Immediate breast reconstruction: indications and technics. Apropos of 120 cases treated at the Institut Gustave-Roussy].

From 1976 to 1986 one hundred and twenty immediate breast reconstructions (IBR) were performed at the Gustave-Roussy Institut. 90% of these cases were treated for in situ or infiltrating carcinomas, while only 10% had prophylactic mastectomy. Over recent decades indications for IBR have progressively changed. In the first period they were reserved for prophylactic mastectomies and in situ carcinomas. Over the last several years IBR has also been proposed to patients with infiltrating carcinomas (30%). Although the adequate treatment for small invasive carcinomas is a radiosurgical conservative procedure, a mastectomy is still indicated in stage II, over three centimeters multifocal carcinomas, and local recurrence after conservative treatment. In our series, this procedure seems safe and advisable as it does not interfere with the treatment of primary and secondary disease. The low incidence of surgical complications reported in our series did not increase the hospital stay of our patients. Indications, surgical techniques including myocutaneous flaps, and results of IBR will be discussed.

Breast↗

PubMed1989

[Current role of radical surgery in the treatment of breast tumors].

Though currently conservative surgical procedures have an ever-growing importance in breast cancer treatment, there is still place for radical surgery. The Authors describe radical techniques and their indications. The surgeon must know how to choose the proper radical technique, when it is not possible to perform a conservative surgical procedure.

Breast Neoplasms↗

PubMed1989

[Angiosarcoma of the breast].

Angiosarcoma of the breast is a rare connective tissue tumour, there having been fewer than 100 cases described. It occurs practically only in women and presents as a phylloid tumour of rapid growth in a young woman. There may be inflammatory phenomena; local trauma is often mentioned. The diagnosis is difficult and relies on the histological examination of biopsy specimens or of the whole specimen removed. The microscopic appearance may be very similar to that of a benign haemangioma. It is necessary to make several cuts and to remember the essential feature of a haemangioma of the breast, namely that it is subclinical and therefore usually discovered microscopically by chance. Treatment consists of simple mastectomy without usually needing to clear the axilla. It is necessary to give polychemotherapy. There is still no agreement on radiotherapy and hormone therapy. The prognosis is very serious because the mean length of survival is around 22 months. We report a recent case of angiosarcoma of the breast in which diagnostic steps were taken in order, and for which expert histological opinion made it possible to diagnose the condition in less than one month. A 37 year old woman had been complaining of the recent appearance of a tumour in her right breast which was growing rapidly because at the first consultation, within one month after her first signs, it measured 50 mm in diameter. It was poorly outlined, multinodular and non-inflammatory.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗