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Aortic graft infection due to Pasteurella haemolytica and group C beta-hemolytic streptococcus.

Although infection is a rare complication of aortic bypass grafting, we treated a 50-year-old patient who developed aortic graft infection due to Pasteurella haemolytica and group C beta-hemolytic streptococcus. The source of the infection could not be verified; however, after removal of the infected graft and administration of a 6-week course of intravenous ampicillin, he recovered fully. We discuss the etiology and pathogenesis of this rare infection.

Aorta↗

Three cases of acute mesenteric lymphadenitis due to Pasteurella pseudotuberculosis.

Seventeen cases of mesenteric adenitis were investigated between May and October, 1959, for the presence of virus as well as for evidence of Pasteurella pseudotuberculosis infection. Specimens examined included mesenteric glands, appendix, throat swab, faeces, and serum, although glands were received from only 12 patients. Virus was not isolated from any of the specimens, but evidence of infection with Pasteurella pseudotuberculosis was obtained in three patients. The three cases of acute mesenteric lymphadenitis due to Pasteurella pseudotuberculosis are reported. Pasteurella pseudotuberculosis Type IA was isolated from the mesenteric glands of two of the cases, and all three cases showed serological evidence of infection with the organism. The mesenteric glands of two of the cases showed histological changes characteristic of pseudotuberculosis.

Acute Disease↗

Late infection after total knee arthroplasty caused by Pasteurella multocida.

The authors report a case of Pasteurella multocida infection in a total knee arthroplasty as a result of a dog bite. The patient was treated with one-stage reimplantation of a new prosthesis and with intravenous antibiotics, resulting in complete relief of symptoms with no evidence of recurrence of infection after 24 months.

Aged↗

A strain of Pasteurella multocida associated with infections in rabbit colonies.

Pasteurella multocida was isolated from 4 conventional rabbit colonies. Amongst 51 isolates, 48 (94%) belonged to a group of strains with similar morphological, cultural, biochemical and antigenic characteristics; they were named for convenience Lo strains and gave rise to local or ascending infections. All Lo strains were found to be a new serotype, but 8 of them had additional antigenic factors characteristic of known serotypes. The other 3 isolates (6%) were identified as serotype 3, known to have a wide host range: 2 strains were associated with septicaemia and haemotogenic spread, and 1 with snuffles. Diagnostic agglutinating antibodies were present in the sera of adult rabbits. Maternal antibodies were in the sera of adult rabbits. Maternal antibodies were in the sera of rabbits of 3 and 4 weeks old, but by the age of 8 weeks the titres had fallen to an undetectable level.

Agglutination Tests↗

Antimicrobial susceptibility patterns of respiratory tract pathogens from sheep and goats.

OBJECTIVE: To determine the antimicrobial susceptibility of common respiratory tract pathogens from sheep and goats. DESIGN: Cross-sectional study. SAMPLE POPULATION: 41 respiratory tract isolates from sheep and 36 isolates from goats. PROCEDURES: Disk diffusion assay was used to determine antimicrobial susceptibility of isolates to amoxicillin-clavulanic acid, ceftiofur, ciprofloxacin, florfenicol, and tetracycline. Minimum inhibitory concentrations of florfenicol for these isolates were determined by use of the microbroth dilution technique. RESULTS: The most common isolates were Pasteurella multocida (n = 28) and Mannheimia haemolytica (39). All isolates were susceptible to amoxicillin-clavulanic acid, ceftiofur, ciprofloxacin, and florfenicol. Five percent (4/77) of isolates were resistant to tetracycline. CONCLUSIONS AND CLINICAL RELEVANCE: Susceptibility of respiratory tract pathogens isolated from sheep and goats to commonly used antimicrobial drugs in this study was high. Treatment of these species for bacterial respiratory tract disease is likely not complicated by antimicrobial resistance.

Animals↗

Evaluation of A live trivalent vaccine for infectious bovine rhinotracheitis virus, para-influenza type-3 virus and Pasteurella multocida in calves.

A live trivalent vaccine for Infectious Bovine Rhinotracheitis virus (IBR), Para-influenza type-3 virus (PI3) and Pasteurella multocida type B vaccine was prepared. The preparation contained 10(7) TCID50 of IBR, 10(7) TCID50 of PI3 & 10(9) CFU of P. multocida type B per 3 ml. Ten calves (5-7 days old) were vaccinated intranasally while five unvaccinated calves of the same age were used as control. Vaccinated calves were examined daily for disease manifestation. Serum and nasal secretion specimens were collected prevaccination and at 7, 15, 21, 30, 45 and 60 days following vaccination. The results indicated that, intranasal vaccination with the live trivalent vaccine stimulates the development of satisfactory level of circulating and mucosal antibodies. It is concluded that the prepared vaccine may be useful for controlling Bovine respiratory disease in calves.

Animals↗

Management of cat and dog bites.

An estimated 1 to 2 million Americans are bitten by cats and dogs each year. Most victims are children who are bitten by dogs. Dog and cat bite wounds may appear trivial, but if they are not managed appropriately, they can become infected and may result in functional impairment. Cat bite wounds on the hand have the greatest risk of infection. Pasteurella multocida, isolated in over half of all cat bite wounds and in 20 to 30 percent of dog bite wounds, can cause serious infection with severe complications. Amoxicillin-clavulanate is recommended for the outpatient treatment of dog and cat bite wounds. Tetanus immunization status and the risk of rabies infection should be routinely addressed in bite wound management.

Animals↗

Effect of aerosol age on the infectivity of airborne Pasteurella tularensis for Macaca mulatta and man.

Sawyer, William D. (U.S. Army Medical Unit, Fort Detrick, Frederick, Md.), Joseph V. Jemski, Arthur L. Hogge, Jr., Henry T. Eigelsbach, Elwood K. Wolfe, Harry G. Dangerfield, William S. Gochenour, Jr., and Dan Crozier. Effect of aerosol age on the infectivity of airborne Pasteurella tularensis for Macaca mulatta and man. J. Bacteriol. 91:2180-2184. 1966.-In aging aerosols of Pasteurella tularensis SCHU-S4, the respiratory infectivity for man and Macaca mulatta decreased more rapidly than the viability of the organisms. Infectivity was diminished after 120 min, and was reduced 10-fold after 180 min. These findings confirmed previous observations made in mice and guinea pigs, and also revealed that smaller losses of infectivity were detectable in the primate hosts.

Aerosols↗

Tilmicosin does not inhibit interleukin-8 gene expression in the bovine lung experimentally infected with Mannheimia (Pasteurella) haemolytica.

The expression of the interleukin-8 (IL-8) gene was examined by in situ hybridization in lung tissues from calves experimentally infected with Mannheimia (Pasteurella) haemolytica and treated with tilmicosin. Interleukin-8 mRNA expression was detected in alveolar areas, particularly along interlobular septa, in the lumen, and in the epithelial cells of some bronchioles. In lesional lung tissues from animals that had received tilmicosin, we found large areas with limited inflammation. There was no staining for IL-8 mRNA in these areas. In contrast, in strongly inflamed areas, the same patterns and intensities of staining for IL-8 mRNA were detected in tilmicosin- and sham-treated animals. We conclude that tilmicosin does not affect the expression of IL-8 mRNA in tissue showing microscopic signs of inflammation. Together with previous reports, this supports the view that the pro-apoptotic properties of tilmicosin on neutrophils do not compromise the host defense mechanisms required to control the infection.

Animals↗

Aortic endograft infection due to Pasteurella multocida following a rabbit bite.

Abdominal aortic endograft infection is a serious complication after an endovascular abdominal aortic aneurysm repair. Pasteurella multocida, a gram-negative bacterium, is a commonly found organism in the mouth flora of many house pets. We report a case of an aortic endograft infection caused by P multocida after a rabbit bite. Successful treatment was performed by extra-anatomic revascularization followed by endograft removal.

Aged↗