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At least 451 records · Page 25Linked to original sources
PubMed2000

Induction pain perception after premedication with propofol vs lidocaine: a pilot study.

Propofol, an intravenous (i.v.) sedative-hypnotic agent, is commonly used for the induction of general anesthesia. It has, however, a substantial potential for causing burning pain at the i.v. site. Several preinduction pharmacologic agents are used routinely to blunt or diminish this burning sensation. Little is published on the effect of a preinduction dose of propofol for pain reduction. Lidocaine, the most studied agent, is recommended by the manufacturer of propofol as a preinduction agent to minimize this burning sensation. If lidocaine could be eliminated, time and cost savings from decreased use of drug, syringes, needles, and alcohol swabs would be realized. The purpose of this study was to determine the clinical effectiveness of administering preinduction doses of lidocaine vs propofol for decreasing pain experienced during anesthetic induction with propofol. Thirty unmedicated patients, ASA physical status I or II, scheduled to undergo general anesthesia for a surgical procedure were included. Patients were randomly assigned, using a random number chart, to receive 20 mg propofol or 40 mg lidocaine intravenously before entering the operating room suite. A minimum of 30 seconds, but not more than 45 seconds, following the administration of randomized drug with open-flow i.v. fluid, the induction dose of propofol (2.5 mg/kg) was begun through the same i.v. site. When one half of the dose had been administered and cleared the tubing by visualization, the patient was asked whether any discomfort was felt in the hand. If the response was yes, the patient was asked to rate the pain as mild, moderate, or severe. Then, the anesthetic process continued normally. No statistically significant difference occurred in pain prevention between treatment groups. In the lidocaine group, 53% (8/15) of patients were pain-free; in the propofol group, 47% (7/15) were painfree. However, when pain occurred, it was more likely to be classified as severe by the propofol group, 50% (4/8), compared with the lidocaine group, 14% (1/7). No difference existed in the ability of propofol or lidocaine to decrease the incidence of pain during an induction dose of propofol. The incidence of severe pain, however, was more frequent in the propofol group. The small number of patients experiencing severe pain precluded statistical analysis. Blunting pain associated with propofol warrants further study.

Adolescent↗
PubMed2005

Attenuation of pain perception after transposition of the greater omentum to the cauda equina region of rats--a preliminary observation.

BACKGROUND: This paper addresses a specific experimental design to suggest the possible role of the greater omentum in the modulation of pain in rats. METHODS: Fifteen male Sprague-Dawley rats weighing between 275 and 325 g were selected. The animals were randomized and then anesthetized with pentobarbital (35 mg/kg) and divided into three groups: (1) sham: laparotomy followed by laminectomy with exposure of the spinal epidural space (n=5); (2) transposition of pedicled omentum (n=5) to the cauda equina epidural space; and (3) transposition of pedicled omentum (n=5) to the cauda equina intradural space. The animals were operated upon and once more randomized by an independent investigator, so that the groups were thought to be similar during post-operative testing. The latency of paw withdrawal to noxious heat stimulation was tested and the values (seconds) plotted for 1, 3, 6, 11, 14 and 30 days after surgery. Randomization codes were open after the animals were euthanized. The analysis of variance (ANOVA) without replication was applied for each of the dataset and comparisons established among the different study groups involved. The omenta were removed and standard immunohistochemistry was performed for gamma-amino-butyric acid (GABA), serotonin, calcitonin-gene related protein (CGRP), vascular intestinal peptide (VIP) and Met-enkephalin. RESULTS: The response to high heating rates of stimulation favored intradural versus sham and epidural omental transpositions. High and low noxious heat stimulation suggested an increased threshold to noxious stimulation after the 3 and 30 days of omental transposition. In the low heat stimulation series, responses were comparatively higher than in the sham animals. CONCLUSIONS: The suggested increased threshold of response to noxious stimulation after transposition of the greater omentum onto the spinal cord of rats suggested a novel role of the omentum and a potential future application in the clinical arena.

Analysis of Variance↗
PubMed2004

30-MINUTES-TUMT. Use of the visual analogue scale to investigate patients' pain perception, different cocktail options and tolerability during 30 minutes' treatment.

INTRODUCTION PRIMARY OBJECTIVE: to investigate if 30-MINUTES-TUMT can be performed under topical anesthesia and analgesics. SECONDARY OBJECTIVES: to evaluate retrospectively analgesics and to study parameters connected with pain. MATERIALS AND METHODS: Eighty-nine patients underwent TUMT. Patients were divided into four groups with different medications. Paracetamol and tolterodin-L-tartrate were administered in all groups. The first group was also given hydromorphone hydrochloride and atropine sulphate, the second group dextropropoxyphene, the third group morphine and diclofenac, and the fourth group morphine and dextropropoxyphene. Pain during TUMT was registered using the VAS scale. RESULTS: Pain during TUMT was (VAS in mm), respectively, total-first-second-third-fourth group: at 5 min -30, 31, 12, 28, 35; at 15 min -30, 23, 16, 25, 34; at 25 min -30, 28, 18, 25, 35. All patients accepted the treatment. No significant difference between the different drug schedules was noticed. CONCLUSIONS: It is possible to treat patients with 30-MINUTES-TUMT with local anesthesia and analgesics. The pain can be accepted by all patients.

Aged↗
PubMed2004

Coronary artery bypass graft patients' pain perception during epicardial pacing wire removal.

Surgical placement of temporary epicardial pacing wires (EPWs) onto the epicardial surface of the heart is standard practice during cardiac surgery. The purpose of this study was to determine the intensity and quality of pain and sensations experienced during the procedure of EPWs removal for coronary artery bypass graft (CABG) patients. A descriptive study, incorporating the McGill Pain Questionnaire-short form and visual analogue scales, was used with 100 CABG patients requiring EPW removal. The pain intensity was reported as mild (47%), while the main sensation experienced was pulling (70%). Age, gender, previous cardiac surgery and EPW removal experience, and use of analgesics did not influence the pain and sensations experienced. However, subjects who had EPWs removed on post-operative day five or earlier did present with higher MPQ-SF affective and combined scores. CABG patients can be prepared for EPW removal by providing information that the procedure is a mildly painful, pulling sensation.

Adult↗
PubMedDate not supplied

[Pain and pain perception in the elderly from the viewpoint of rheumatology].

In rheumatology there is the problem of different terminologies and classification systems; additionally there are only few studies on differential diagnosis and course of diseases in people over 65. The analysis of pain is important for diagnosis; people often have problems in exactly describing their pains. The character of pain changes in the course of disease; therefore a continuous pain analysis is necessary.

Aged↗
PubMed2006

Effects of isometric contraction on intramuscular level of neuropeptide Y and local pain perception.

OBJECTIVE: The release of neuropeptide Y (NPY) is reported to increase in ischemic conditions and may thus be involved in chronic myalgia. The purpose of this study was to investigate the effect of isometric contraction on intramuscular levels of NPY in relation to local pain development. MATERIAL AND METHODS: Intramuscular microdialysis was performed in the masseter and trapezius muscles to determine NPY levels before, during, and after isometric contraction in 16 healthy females. Pain intensity was assessed simultaneously with VAS. Repeated measures ANOVA, t-test, and Pearson correlation analysis were used for statistical analyses. RESULTS: The level of NPY in the trapezius muscle was increased during and after contraction, while there was no change in the masseter muscle. The level of NPY before contraction was higher in the masseter muscle than in the trapezius muscle, and the levels in the two muscles were correlated before and during contraction. Low-level pain in both muscles after probe insertion increased significantly during contraction, but the pain was not correlated to the NPY level. CONCLUSIONS: Pain is developed in the trapezius and masseter muscles during repeated isometric contraction. The NPY level is increased in the trapezius muscle but is not associated with the pain development.

Bite Force↗
PubMedDate not supplied

Pain perception and utility: a comparison of the syringe and computerized local injection techniques.

Thirty patients received maxillary infiltration and mandibular inferior alveolar nerve block injections with both a traditional syringe and a computerized system, the Wand. Patients noted their preference for either system and rated their injection pain and postoperative discomfort on a ten-point scale for each type of injection. Mean injection discomfort ratings with the Wand were lower than with the syringe but were not statistically significant. Reduced postoperative discomfort using the Wand for the inferior alveolar nerve block was significant. Both of the dentists in the study and those patients who stated a preference favored the Wand system.

Adult↗