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At least 451 records · Page 25Linked to original sources
PubMed2003

Th1 and Th1-inducing cytokines in Salmonella infection.

Thl and Thl-inducing cytokines and T cell responses were investigated in human salmonellosis. Serum IFN-gamma, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis. The increase in serum IL-15 and IL-18 levels was more significant and prolonged in patients with the systemic form of salmonellosis than in those with the gastroenteric form. The serum IFN-gamma level was correlated significantly with IL-12 and IL18 levels, and the IL-15 level was correlated significantly with IL-18. Upon stimulation with Salmonella in vitro, mononuclear cells from salmonellosis patients produced significantly higher amounts of IFN-gamma and IL-12 compared with those from healthy controls. Anti-IL-12 moAb or anti-IL18 MoAb significantly inhibited Salmonella-induced IFN-gamma production in vitro. gamma delta T cells expressed significantly higher levels of IFN-gamma mRNA in salmonellosis patients than in healthy controls. The results suggest that Th1-inducing cytokines appear to be involved in the in vivo response against Salmonella infection, promoting IFN-gamma production by alpha beta and gamma delta T cells which plays a protective role against Salmonella.

Adolescent↗
PubMedDate not supplied

Evaluation of cross-protection afforded by a Salmonella Choleraesuis vaccine against Salmonella infections in pigs under field conditions.

This field study investigated the efficacy of a Salmonella Choleraesuis live vaccine (Argus SC) to reduce the number of infections with Salmonella. Twelve groups of about 380 pigs each were randomly allocated to either vaccination (V) or no vaccination (C). The vaccine was applied orally at 3 and 16 weeks. Forty pigs per group were blood sampled at 3, 10, 16, and 24 weeks to detect possible antibodies against Salmonella. The prevalence of Salmonella in the lymph nodes was the major variable. In the V groups, only 0.6% of the lymph nodes were positive, whereas 7.2% were positive in the C groups (p < 0.001). The percentage of seropositive pigs at 24 weeks (cut-off OD > 10) was 26% and 9% in the V and C groups, respectively (p < 0.001). The present study documented that vaccination with a live modified S. Choleraesuis vaccine is a useful tool to lower the prevalence of Salmonella in swine herds.

Animals↗
PubMed1998

Abortion in foxhounds and a ewe flock associated with Salmonella montevideo infection.

Salmonella montevideo is a recognised cause of ovine abortion and can cause disease in other domestic animals and humans. The organism was isolated from the aborted fetuses of a bitch from a pack of foxhounds. The subsequent collection of rectal swabs from the foxhounds at approximately two week intervals over a 48-day period resulted in the isolation of S montevideo from 50 of the 61 hounds in the pack on one or more occasions. Some of the hounds had gained access to an open pit containing dead ewes and aborted fetuses on a farm where the housed ewe flock was experiencing S montevideo infection. The S montevideo isolates from both the ovine and canine samples had a plasmid of 120 kilobases with an identical restriction endonuclease fragmentation pattern. The only other isolate from a contemporary outbreak lacked this plasmid. It was concluded that this case offered further evidence of the potential for salmonella infection to be spread by the scavenging of carcasses.

Abortion, Veterinary↗
PubMed1983

Non-typhoidal Salmonella infection in Zambian infants.

In the University Teaching Hospital, Lusaka, Zambia, 45 strains of various non-typhoidal Salmonella species were isolated from 2990 samples of stools, blood and C.S.F. About 93% of the 45 strains were isolated from infants less than two years old. S. heidelberg was the most common species isolated from stools and revealed a multi-drug resistant character. Only S. typhimurium and S. bovis-morbificans were isolated from blood and C.S.F.

Adult↗