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Results for “SOCIAL ISOLATION”

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PubMed1993

Biphasic effects of typical antidepressants and mianserin, an atypical antidepressant, on aggressive behavior in socially isolated mice.

Effects of several typical antidepressants and of an atypical antidepressant, mianserin, on the aggressive behavior (AGB) in long-term isolated mice were examined. IP administration of maprotiline (2.5 and 5 mg/kg), amitriptyline (5 and 10 mg/kg), clomipramine (2.5 and 5 mg/kg), and mianserin (5 mg/kg) significantly increased the duration of AGB. However, at higher doses (maprotiline, 10 mg/kg; amitriptyline, 20 mg/kg; clomipramine, 10 and 20 mg/kg; mianserin, 10 and 20 mg/kg) these antidepressants either did not affect AGB or inhibited it. Amitriptyline (20 mg/kg) and mianserin (10 mg/kg) but not maprotiline (10 mg/kg) or clomipramine (20 mg/kg) decreased spontaneous motor activity in isolated mice. Yohimbine (0.5 mg/kg, IP), an alpha 2-antagonist, changed the antidepressant-induced enhancement of AGB into inhibition without affecting the basal aggressive responses. Prazosin (0.3 mg/kg, IP), an alpha 1-antagonist, did not affect either maprotiline- or clomipramine-induced enhancement of AGB, but it changed the mianserin-induced enhancement of AGB into inhibition. These results indicate that antidepressants that inhibit noradrenaline uptake and/or stimulate noradrenaline output from nerve terminals have biphasic effects on AGB in isolated mice and that the antidepressant-induced enhancement of AGB is mediated by noradrenergic stimulation of alpha 2-adrenoceptors, whereas the antidepressant-induced inhibition of AGB may be mediated by non-alpha 2-adrenoceptors or by nonadrenergic system(s).

Aggression↗
PubMedDate not supplied

Effects of early weaning and social isolation on subsequent alcohol intake in rats.

The present study investigated the influence of early weaning and separation from mother and littermates on voluntary ethanol intake and general activity during prepuberal age, and adult age corticosterone levels. On day 16 after birth the male offspring of a litter were divided in three groups, each subjected to a different rearing condition: 1)early weaned and isolated from its littermates; 2) early weaned but growing up together with two littermates; 3) staying with mother and two littermates. On day 25 the animals were tested for general activity including assessment of fearfulness. From day 30 all animals were given a free choice between water and ethanol solution. The ethanol concentration was increased by 2% during each of the following weeks until 10% was reached during the 5th week. Ten days later, after cessation of alcohol testing, blood samples were taken from the tail for assessment of plasma levels corticosterone. The isolated, early weaning pups displayed higher activity levels than both normally reared pups and group-living, early weaning pups. The quotient peripheral locomotion/total locomotion was lower for the isolated pups compared with the other groups, suggesting less fearfulness in the early weaned, isolated pups. For 2%, 4%, and 6% ethanol solutions the normal-reared rats consumed more ethanol and displayed higher ethanol preference than either of the early weaned groups of animals. No group differences were observed either at 8% or 10% ethanol solutions. Levels of plasma corticosterone in adult age in the early weaned rats were slightly reduced, not reaching statistical significance, compared to the normally weaned animals.

Aging↗
PubMed1975

Consequence of social isolation on blood pressure, cardiovascular reactivity and design in spontaneously hypertensive rats.

Spontaneously hypertensive rats (SHR), which inherently display exaggerated cardiovascular defence reactions to environmental stimuli (Hallbäck and Folkow 1974), and normotensive control rats (NCR) were kept isolated after they were weaned to reduce such environmental influences which normally induce psychological activation. Mean arterial pressure was followed until 7 months of age, when the cardiovascular defence reactions to acute mental stress were compared and an analysis of cardiovascular design was made. The isolated SHR but no the isolated NCR, had significantly lower pressures than their unisolated controls. Likewise, judged by the relative weight of the left ventricle and the hemodynamically evaluated design of the hindquarter resistance vessels, the structural cardiovascular adaptation was about proportionally less pronounced in isolated than in control SHR. However, their cardiovascular responses to acute "psychological stress" were equally intense, and clearly exaggerated when compared with NCR. Thus, a prolonged reduction of excitatory environmental influences implies a relatively less pronounced development of hypertension in SHR, even though an inherent hyperreactivity concerning neurohormonal pressor responses to alerting stimuli is present. These findings tress the importance of interacting intrinsic-hereditary and extrinsic neurogenic influences for the initiation of primary hypertension.

Acoustic Stimulation↗
PubMed1981

Oral imagery and autonomic arousal in social isolation.

Psychoanalytic theory suggests that the presence of others reduces anxiety in those with oral-dependent needs. Electrodermal activity of male subjects high and low on Rorschach oral-dependent responses was monitored in one of three conditions while the subject was in a soundproof chamber for 40 minutes: alone with no task; alone working on a clerical task; and together with a male confederate, both working independently on the clerical task. Oral-dependent subjects placed in the chamber with the confederate showed fewer electrodermal increase over time than orals sitting alone or nonorals either alone or with the confederate (p less than .001). On the clerical task there was a strong main effect of orality, with nonorals showing more accuracy than orals (p less than .03).

Anxiety↗
PubMed2006

Is television viewing associated with social isolation? Roles of exposure time, viewing context, and violent content.

OBJECTIVE: To estimate associations between children's peer integration and amount of time they spend (1) watching television, (2) watching violent television, and (3) co-viewing television with friends. DESIGN: Survey using nationally representative data from the Panel Study of Income Dynamics-Child Development Supplement Wave 1. SETTING: Nationwide survey of families with young children performed in 1997. PARTICIPANTS: Of 3562 children, 1356 had sufficient data for inclusion in analyses (563 children aged 6 to 8 years and 793 children aged 9 to 12 years). MAIN EXPOSURE: Total time viewing television, with and without friends present, and time viewing violent and nonviolent television content. MAIN OUTCOME MEASURE: Amount of time children spent with friends as reported in two 24-hour activity diaries. RESULTS: Viewing violent programs (but not nonviolent programs) was negatively related to time children spent with friends (aged 6-8 years, unstandardized regression coefficient [beta] = - 0.34, 95% confidence interval [CI], - 0.59 to - 0.08; aged 9-12 years, beta = - 0.41, 95% CI, - 0.65 to - 0.18). More time viewing television with friends was associated with more time engaging in other activities with friends (aged 6-8 years, beta = 0.98, 95% CI, 0.61 to 1.36; aged 9-12 years, beta = 1.03, 95% CI, 0.72 to 1.34). CONCLUSIONS: The more time that children spent viewing violent programs, the less time they spent with their friends. While this study cannot determine the direction of effects for this relationship, a cyclical process between violent media and peer integration best explains the findings. To optimize social development and mental health, children's access to violent media should be limited.

Age Factors↗
PubMed1986

Central norepinephrine and plasma corticosterone following acute and chronic stressors: influence of social isolation and handling.

Exposure to acute inescapable shock resulted in a decline of hypothalamic norepinephrine (NE), and an increase of plasma corticosterone concentrations. With repeated application of the stressor over 15 successive days the reduction of NE was eliminated and concentrations of the amine actually exceeded those of control animals. In contrast to the NE variations, plasma corticosterone concentrations were elevated irrespective of whether mice received a single or repeated sessions of inescapable footshock. Moreover, unlike NE concentrations, handling mice on successive days in the absence of the shock treatment was sufficient to provoke a modest, but reliable increase of corticosterone concentrations. It is suggested that the hypothalamic NE and plasma corticosterone changes may be reflective of different attributes of the stressor or are subserved by different mechanisms. It is suggested that variations in both these systems represent adaptive changes to meet environmental demands.

Animals↗
PubMed1998

The effects of social isolation on the forced swim test in Fawn hooded and Wistar rats.

Although the forced swim test (FST) has long been used as a preclinical screen of antidepressant efficacy, locomotor stimulants are known to produce confounding effects using the traditional dependent measure in this test: immobility. It has recently been suggested that measurement of struggling behavior may be a better index of antidepressant activity. The present experiments examined behavior in the forced swim test in two potential animal models of depression: the Fawn hooded rat, and the isolation-reared rat. No evidence was found to support these assertions, indeed immobility was decreased in Fawn hooded compared to Wistar rats, however this appeared to be caused by increased struggling behavior in Fawn hooded socials and increased swimming in Fawn hooded isolates. Although these differential results are highly suggestive of different underlying causes of decreased immobility in Fawn hooded rats depending on rearing conditions, the data suggests that the underlying psychological functions assumed to be represented by behavior assessed in this paradigm may not be adequately discriminated.

Animals↗
PubMed2001

Social isolation of mature workers affects nestmate recognition in the ant Camponotus fellah.

This study investigates the role of social stimulation on nestmate recognition in mature workers of Camponotus fellah. We isolated 4-week-old workers before examining their behaviour in dyadic reunion tests. At the age of 4 weeks, workers are normally intolerant towards both allospecific and homospecific but allocolonial individuals. However, when they were isolated for up to 20 days, allocolonial aggressions decreased while allospecific aggression remained constant. Workers isolated for 20 days also engaged in allocolonial trophallaxis. These results suggest that workers need to be reinforced by social stimulation during their adult life to keep precise nestmate recognition capacities. We discuss our data under the perspective of recent neuroethological data in social insects to propose a mechanism for the formation of the neural template used in the nestmate recognition process.

Journal Article↗
PubMed1989

Combined effects of job strain and social isolation on cardiovascular disease morbidity and mortality in a random sample of the Swedish male working population.

This study examined the impact of psychosocial work organization on cardiovascular disease (CVD) morbidity and the nine-year cumulative mortality incidence for a random sample of the male Swedish working population (N = 7219). A multiplicative measure was constructed to model the combined effects of psychological job demands, work-related social support and work control. Highly strained and isolated workers had a higher age-adjusted prevalence ratio for CVD morbidity and a higher age-adjusted risk ratio for CVD mortality when compared with those working under less strained and more collective conditions. Blue-collar workers showed the greatest risk for both morbidity and mortality when groups with highly isolated and strained conditions were compared to those in more collective and less strained conditions. Strained and isolated workers also had a substantially higher probability of developing and dying of CVD at a younger age than did those in less adverse environments.

Adult↗
PubMedDate not supplied

Support for caregivers of dependent elderly. A support group can help a dependent elderly person by helping a caregiver overcome feelings of social isolation.

The sharing of feelings and the sense of affiliation with and support from others was felt to be the most beneficial aspect of the group participation. Emotions described by participants included revitalization, dissipation of tension and guilt, and a renewal of their sense of identity. Attendance at the group created a social outlet that helped several members feel more socially integrated. Participants began to understand that appropriate attention to their own needs improved their outlooks and brought new energy to their role as caregivers. Nurses planning to study the impact of support groups should consider using a research design, a longitudinal design, to examine changes in caregiver stress occurring with alterations in the care receiver's illness, and to address the economic impact of support groups in reducing health care cost.

Aged↗
PubMedDate not supplied

The Enhancing Recovery in Coronary Heart Disease Trial (ENRICHD): strategies and techniques for enhancing retention of patients with acute myocardial infarction and depression or social isolation.

The report aims to review the literature and describe the methods used for retention of patients in a clinical study. The Enhanced Recovery in Coronary Heart Disease (ENRICHD) trial was a multicenter, randomized clinical trial designed to evaluate the effects of a psychosocial intervention on cardiovascular morbidity and mortality. A total of 2481 patients met the criteria for depression, low social support, or both after a myocardial infarction and needed to be followed. Follow-up evaluation consisted of telephone interviews 3, 9, 12, 24, 36, and 48 months after enrollment and clinic visits scheduled at 6, 18, 30, 42, and 54 months. Creative strategies used to achieve optimum retention of this complex patient population over a long follow-up period are presented. Strategies to enhance adherence throughout the course of the trial required adequate tracking of patients to ensure minimum dropout, follow-up evaluation optimized through multiple methods of contact to guarantee completeness of data collection; and development of procedures to address the needs of patients at risk for dropout. Patients in the group that completed the study participated for a mean of 28.3 months, and those lost to follow-up evaluation participated for a mean of 19 months. Retention was not substantially different by gender or minority status. The results of this project can assist investigators in planning studies that require patient follow-up evaluation, and can provide clinicians with specific strategies for maximizing retention-to-treatment recommendations. As a result of the retention strategies described in this report, 93.02% of the patients completed their study participation or died. This is a very high retention rate given the complexity of the study sample, protocol, and required duration of follow-up evaluation.

Adult↗
PubMedDate not supplied

Overcoming hopelessness and social isolation: the ENGAGE model for working with neglecting families toward permanence.

The Adoption and Safe Families Act of 1997 (ASFA) mandates policies designed to increase the frequency and speed with which permanency is achieved for children in the child welfare system. ASFA's focus is on child safety, permanency, and well-being. The expectation that parents correct neglectful conditions within specified time frames places an increased ethical responsibility on child welfare staff. Carrying out this responsibility requires vigorous and innovative approaches to engaging and working with neglectful families. Drawing on a well-established conceptual framework for understanding the determinants of effective parenting, the authors derive the ENGAGE (Engagement, Needs assessment, Goal setting, Assessment of progress, Goal achievement, Ending work) model for achieving permanency within the policy structure. The model incorporates creative client engagement, assessment of family needs, mutual goal setting, the goal achievement process, termination, and aftercare.

Anomie↗
PubMed1997

Scientific organizations in Spain (1950-1970): social isolation and international legitimation of biochemists and molecular biologists on the periphery.

Through a study of Spanish scientific organizations and the involvement of Spanish scientists in international ones, the beginnings of biochemistry and molecular biology in Spain are explored. The centre-periphery dichotomy is useful in explaining the progress of the establishment of these disciplines, together with the political context, both national and international, in which such establishment took place. It is suggested that international ties and national support are both necessary, but not sufficient conditions to overcome the distance between the Spanish scientific community and the centres of development and productivity in biochemistry and molecular biology. The interplay between both national and international factors has proved to be crucial. As a tool to study the whole scientific community of biochemists and molecular biologists, scientific societies allow us to analyze the role of that interplay in Spanish scientific development.

Biochemistry↗