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At least 451 records · Page 25Linked to original sources
PubMed1995

[Disseminated extrapulmonary tuberculosis in idiopathic CD4-lymphocytopenia].

A previously healthy, now 42-year-old man suddenly fell ill with bouts of septic fever up to 39.5 degrees C, sweats and weight loss without any demonstrable organ involvement. Physical examination on hospitalization 3 weeks after onset of the illness was unremarkable. Blood sedimentation rate at one hour was 123 mm. There was also a moderate increase in gamma-GT and alkaline phosphatase. Routine bacteriological and serological tests failed to discover a causative microorganism. After imaging tests had provided first indication of splenic and hepatic involvement, biopsies of these two organs demonstrated disseminated epithelioid granulomas and Langhans giant cells. Staining and culturing of pelvic crest biopsy tissue showed evidence of Mycobacterium tuberculosis, but there was no evidence of pulmonary involvement. In addition to four-drug tuberculostatic treatment the patient was given glucocorticoids for several weeks to control the fever bouts. Persistent CD4+ T-lymphocytopenia was demonstrated as the cause of the entirely extrapulmonary tuberculosis in this HIV-negative patient. This is an only recently described and so far unexplained syndrome.

Adult↗
PubMed2002

[Isolated tuberculosis of the spleen. Report of a case].

Isolated tuberculosis of the spleen is rare and difficult to diagnose. The features and management of this disease are discussed based on one case. A 52-year-old woman, presented with fever of unknown origin and splenomegaly. Ultrasonography and computed tomography demonstrated heterogeneous areas within the spleen. The diagnosis was made by a pathologic study of a splenic fragment obtained during laparotomy. When the spleen is the only organ involved by tuberculosis, the diagnosis is usually made by a pathologic study of splenic tissue obtained during laparotomy or percutaneous needle biopsy.

Female↗
PubMed1976

Spleno-hepatic tuberculosis due to Mycobacterium kansasii.

A case of tuberculosis of the spleen and liver is described. The organism involved was Mycobacterium kansasii, one of the atypical mycobacteria. The lack of evidence in the literature of primary splenic or hepatic involvement by this organism suggests that it is rare. In this instance it complicated a case of myeloproliferative disease, megakaryocytic myelosis with extra-medullary haemopoiesis, and was not diagnosed until autopsy.

Autopsy↗
PubMed1992

Splenic abscess: sonographic diagnosis and percutaneous drainage or aspiration.

During a recent 5-year period, 12 patients with splenic abscesses were evaluated by abdominal ultrasound (US) examination. Multifocal abscesses were noted in seven patients, three of them were secondary to infectious endocarditis, three were in immunosuppressed state, and one was caused by tuberculosis. The latter four patients had developed splenic microabscesses with a diameter of less than 1.5 cm. The larger abscesses showed an irregular wall, weak or no internal echoes, ovoid or round in shape, and accompanied by mild to moderate distal acoustic enhancement. Wedge-shaped abscesses were typically noted in patients with infectious endocarditis and septic embolism. US-guided percutaneous drainage was done in five patients (abscesses greater than 4 cm). Simple aspiration in conjunction with antibiotic administration was done for seven smaller abscesses (diameter less than 3.5 cm) in five patients. A second drainage, either for a dislodged catheter or a recurrent abscess, was performed in two cases. All patients had uneventful clinical course following this therapeutic approach.

Abscess↗
PubMedDate not supplied

[Laparoscopy in black African immigrants. Apropos of 60 cases].

Authors give results about 60 laparoscopies in negro immigrants. If one excepts isolated cases of liver cirrhosis, hepatoma, staphylococcic liver abscess, lymphosarcoma or schistosomiasis of the peritoneum and twelve normal laparoscopies, the most frequent diagnosis in this peculiar group is peritoneal and/or liver tuberculosis (21 cases). Endoscopic aspects of hepato-splenic schistosomiasis are summarized. Interest of liver and/or peritoneal biopsies is underlined. Problem of liver granulomatosis may be ambiguous between schistosomiasis and tuberculosis.

Adolescent↗
PubMed1976

Transmissible agents from human sarcoid and Crohn's disease tissues.

Mice were inoculated with human sarcoid tissue homogenates or with a first or a second passage homogenate of mouse tissue (including 0.2 mum membrane filtrates) originating from the inoculation of human sarcoid, Crohn's disease, or control tissue homogenates. Epithelioid and giant cell granulomas were present in the footpads and/or viscera of some of the mice given homogenates originating from each sarcoid or Crohn's disease tissue 15 months after inoculation but were not present in mice given control homogenates. Among mice given homogenates originating from human sarcoidosis, granulomas were present in many organs and tissues; in contrast, a pattern of selective dissemination of visceral granulomas was found among mice given homogenates originating from Crohn's disease. This differential distribution of visceral granulomas also followed the inoculation of 0.2 mum membrane filtrates. Granulomatous responses at Kveim test sites in the ear 9-17 months after inoculation of homogenatesoriginating from human sarcoidosis or Crohn's disease were confined to mice showing granulomas in footpads of viscera. The ability of the transmissible agents to induce granulomas in mice was destroyed when sarcoid or Crohn's tissues were autoclaved or when sarcoid homogenates were stored at -20degreesC for 1 week or exposed to 60Co irradiation (2.5 MR).

Animals↗
PubMed1996

Pulmonary histoplasmosis.

Histoplasmosis is a common infection in the central United States and is acquired through inhalation of airborne spores. The majority of infected persons have an asymptomatic, self-limiting illness. Clinical pneumonia occurs in those with exposure to a large number of infecting spores. Resolution of the pneumonia often leaves calcified pulmonary nodules, calcified mediastinal lymph nodes, or splenic calcifications. Chronic disease, which mimics tuberculosis, may develop in those with underlying emphysema. In patients with deficient cell-mediated immunity, Histoplasma capsulatum may disseminate throughout the body; this often is fatal. Delayed manifestations arise months or years after the primary infection. Broncholithiasis occurs when peribronchial calcific nodes produce bronchial obstruction. Mediastinal granuloma is the continued proliferation of fibrous tissue in draining mediastinal lymph nodes. These granulomas may obstruct adjacent veins, arteries, or airways and lead to various clinical symptoms.

Animals↗
PubMed1991

[Segmental portal hypertension due to a retroperitoneal abscess of tuberculous etiology].

We report a patient with segmental portal hypertension secondary to a retroperitoneal tuberculous abscess. The patient was admitted to the hospital because of upper gastrointestinal bleeding. Gastric varices were the only lesion found at endoscopy. At laparotomy a retroperitoneal abscess was found as the etiology of splenic vein thrombosis. We emphasize the low frequency of this finding and its resolution after splenectomy and antituberculous drugs.

Abscess↗