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PubMed2000

Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects.

The noradrenergic system has been implicated in arousal, vigilance, irritability hostility, and memory. This suggests the hypothesis that genetic variants at noradrenergic receptors may be risk factors of these behaviors. To test this hypothesis, the potential association between measures of these traits and genetic variation at the adrenergic2A receptor gene (ADRA2A), using a common single nucleotide polymorphism (SNP) polymorphism of the promoter region, were examined in two independent sets of subjects: university students (student group), and parents of twins in the Minnesota Twin Study (twin group). In the student group, there was a significant linear association by genotype (11 > 12 > 22) for the total Brown ADD score (BADD), and BADD subscores of memory and irritability, and with the total Buss-Durkee Hostility Inventory (BDHI) score and BDHI subscores of indirect hostility, irritability, negativity, and verbal aggression. A multiple analysis of variance (MANOVA) of all the BADD and BDHI subscores was significant at P < or = 0.009. For the twin group, the same genotype associations were significant for the Multidimensional Personality Questionnaire (MPQ) impulsivity scores but not for the MPQ aggression or harm avoidance scores. The ADRA2A gene accounted for 1.8-8.3% of the variance of these scores.

Adult↗

PubMedDate not supplied

The relation between mothers' hostile attribution tendencies and children's externalizing behavior problems: the mediating role of mothers' harsh discipline practices.

This study examined relations among mothers' hostile attribution tendencies regarding their children's ambiguous problem behaviors, mothers' harsh discipline practices, and children's externalizing behavior problems. A community sample of 277 families (19% minority representation) living in three geographic regions of the United States was followed for over 4 years. Mothers' hostile attribution tendencies were assessed during the summer prior to children's entry into kindergarten through their responses to written vignettes. Mothers' harsh discipline practices were assessed concurrently through ratings by interviewers and reports by spouses. Children's externalizing behavior problems were assessed concurrently through written questionnaires by mothers and fathers and in the spring of kindergarten and first, second, and third grades through reports by teachers and peer sociometric nominations. Results of structural equations models demonstrated that mothers' hostile attribution tendencies predicted children's future externalizing behavior problems at school and that a large proportion of this relation was mediated by mothers' harsh discipline practices. These results remained virtually unchanged when controlling for initial levels of children's prekindergarten externalizing behavior problems at home.

Child↗

PubMed2004

Depression and hostility as predictors of long-term outcomes among opiate users.

AIMS: This study used data from the national Drug Abuse Treatment Outcome Studies (DATOS) to investigate the associations that pre-treatment depression and hostility have with drug use and criminal behavior at 1 year and 5 year follow-up in patients with and without additional treatment involvement in the year prior to each follow-up. DESIGN: Following a naturalistic, non-experimental evaluation design, admissions to methadone treatment were followed up approximately 1 and 5 years later. Data analysis was conducted using multiple logistic regression. SETTING: Eighteen programs from DATOS were included. PARTICIPANTS: An analytic sample consisting of 727 patients at 1 year follow-up and 432 patients at 5 year follow-up was included. FINDINGS: Multiple logistic regression analyses revealed that greater depression predicted less drug use in the year preceding each follow-up, whereas greater hostility predicted increased drug use and more arrests at each follow-up. Furthermore, these predictive relationships appeared only among individuals not involved in additional treatment. CONCLUSIONS: Depression and hostility showed opposite associations with outcomes, underscoring the need to assess these psychological conditions separately and tailor treatment plans appropriately.

Adult↗

PubMed1993

Disorganized infant attachment classification and maternal psychosocial problems as predictors of hostile-aggressive behavior in the preschool classroom.

This study of 62 low-income families examined the relation between maternal and infant measures assessed at 18 months infant age and child behavior problems at age 5 as rated by preschool teachers. The infancy assessments included measures of mother-infant interaction, maternal psychosocial problems, infant cognitive development, and infant attachment security, including the disorganized/disoriented classification. The strongest single predictor of deviant levels of hostile behavior toward peers in the classroom was earlier disorganized/disoriented attachment status, with 71% of hostile preschoolers classified as disorganized in their attachment relationships in infancy. Maternal psychosocial problems independently predicted hostile aggression in preschool and combined additively with infant attachment security in prediction. Results are discussed in relation to the asymmetry of forward and backward prediction that characterized the findings and in relation to the potential significance of disorganized attachment behavior as a precursor to later maladaptation.

Aggression↗

PubMedDate not supplied

Impact of hostility and withdrawal in interparental conflict on parental emotional unavailability and children's adjustment difficulties.

This multimethod, prospective study examined the nature of pathways between interparental hostility and withdrawal, parental emotional unavailability, and subsequent changes in children's internalizing and externalizing behaviors, and school adjustment difficulties over a 3-year period in a sample of 210 mothers, fathers, and 6-year-old children. The results of autoregressive structural equation models indicated that interparental withdrawal had a detrimental impact on all areas of children's adjustment, whereas interparental hostility had an indirect effect on subsequent changes in child adjustment. An intermediary role of parental emotional unavailability in links between interparental withdrawal and hostility and child outcomes was indicated, with specific, differential effects observed for fathers and mothers.

Affect↗

PubMedDate not supplied

Interictal aggression in epilepsy: the Buss-Durkee Hostility Inventory.

Adult patients with left, right, or bilateral temporal lobe epilepsy or absence epilepsy, and normal controls completed the Buss-Durkee Hostility Inventory (BDHI), a standardized questionnaire of aggressive tendencies. Patients with left temporal lobe seizure foci scores higher on the Suspicion scale than did other patients or controls (p < 0.05). Factor analysis scale scores identified three factors: hostile feelings, covert aggression, and overt aggression. The groups differed on their pattern of factor scores (p < 0.01): patients with left temporal lobe epilepsy scored higher than other groups on hostile feelings, normal controls scored higher on Covert aggression, and bitemporal patients scores higher on Overt aggression. Patients with absence seizures did not differ from controls. Lateralization of the seizure focus in patients with temporal lobe epilepsy may alter expression of aggressive behavior.

Adult↗

PubMed1996

Hostility is associated with a low prolactin response to meta-chlorophenylpiperazine in abstinent alcoholics.

The prolactin response to the administration of serotonin agonists is an index of central nervous system serotonin (5HT) activity. This index is blunted in association with hostile aggression in personality-disordered individuals without substance abuse. We tested whether prolactin response to the partial 5HT agonist meta-chlorophenylpiperazine (MCPP) (0.35 mg/kg po) was associated with measures of trait hostility in alcoholics who were completing a 3-week rehabilitation program after medical detoxification. We also tested whether the same 5HT index differed in the group of alcoholics compared with the healthy volunteers. The prolactin response to MCPP was inversely associated with the main index of trait hostility and was similarly inversely associated with an index of depression. There was, however, no difference in neuroendocrine or temperature responses to MCPP between the alcohol-dependent group and the healthy volunteers.

Adult↗

PubMed1990

Hostility, hopelessness and deliberate self-harm: a prospective follow-up study.

Sixty-one consecutive patients who presented following an episode of deliberate self-harm (DSH) were assessed on a number of variables, including measures of hopelessness and hostility. Attempts were made to follow all of the patients. Those who were known to have had a further episode of DSH had significantly higher levels of hopelessness and intropunitive hostility after the index episode than those who did not repeat. The question of vulnerability to DSH is discussed as well as the possibility of using measures of hopelessness and intropunitive hostility to identify those at greater risk of repetition.

Adolescent↗

PubMed1983

Depression and hostility in self-mutilation.

The presence of depression and hostility among self-mutilating patients is investigated. Mutilators, depressives and controls comprised the research samples. Non-significant differences in intropunitive hostility and depression were found between the clinical groups. Specific item differences in the depression assessment indicated a definite qualitative rather than quantitative difference in depressive symptomatology between the clinical groups. The interaction between hostility and depression and the implications for management based on these results is discussed.

Adjustment Disorders↗

PubMed1977

Hostility, personality and depression.

The study describes findings on two samples of depressives and normals matched for age, sex, social class and religious affiliation. The following observations on the psychopathology of depression were made by considering the relationships between personality, various aspects of hostility, and the degree of depression: (1) depression, guilt and anxiety are linked together; (2) the extent to which anxiety is somatized is not dependent on the way hostility is handled; also, somatic symptoms occur independently of hysterical symptoms in depressive illness; (3) obsessional symptoms are likely to occur together with hysterical symptoms and to be associated with hostility-aggression during depressive illness; (4) hysterical tendencies may accentuate intropunitiveness.

Adolescent↗

PubMed1981

Changes in the hostility of schizophrenic patients during treatment.

Hostility towards self and others often precipitates admission to hospital of the schizophrenic patient. A follow-up study of 24 newly admitted schizophrenic patients during eight weeks of treatment indicated high intropunitiveness and extra-punitiveness at admission which decreased concurrently with psychopathology. The larger change was in intro-punitiveness, resulting in an increase in the original predominance of extra-punitiveness. The various measures of hostility were not predictive of response to treatment at eight weeks. Comparisons between the schizophrenic group and a group of depressed patients indicated significant differences in the expression of hostility. At admission the schizophrenic patients are less intro-punitive and more extra-punitive than the depressed patients, these differences disappearing after eight weeks of treatment. This finding tends to support the psychodynamic view of projective and introjective mechanisms in these two illness groups.

Adolescent↗

PubMed1987

Psychological correlates of hostility among patients undergoing coronary angiography.

The Cook-Medley Hostility (Ho) scale (Cook & Medley, 1954) has been associated with increased risk for coronary heart disease (CHD). There is relatively little information about the psychosocial correlates of the Ho scale in clinical or adult populations, however. In this study, 132 patients (mean age = 53 years) referred for diagnostic coronary angiography completed a battery of self-report questionnaires including the Minnesota Multiphasic Personality Inventory (MMPI), Hopkins Symptom Check List (SCL-90), State-Trait Personality Inventory (STPI), Type A Self-Rating Inventory (TASRI), and Perceived Social Support Scale (PSSS). Examination of the pattern of correlations among the Ho scale and the psychometric instruments revealed that the Ho scale may be viewed as tapping four general behavioural dimensions including anger and hostility, neuroticism, social maladjustment and ineffective coping style. These findings serve to further understanding about the psychological dimensions of hostility as measured by the Cook-Medley Ho scale.

Adult↗

PubMed1978

Hostile interaction in a general hospital ward leading to disturbed behaviour and bulimia in anorexia nervosa: its successful management.

A girl of 17 years with severe anorexia nervosa, treated on a medical ward in a teaching hospital, developed bulimia, stole food, was sometimes doubly incontinent, behaved angrily, and aroused the hostility of patients and staff. The growth of a vicious circle of hostility is described and it was hypothesized that the hostility had aggravated the bulimia. On the basis of this hypothesis the situation was clarified with the patient and staff, attitudes changed, the patient's appetite dropped within a day from about six times to one-and-a-half times the normal and her behaviour became normal. The significance of these events is briefly discussed.

Adolescent↗

PubMedDate not supplied

Perceived difficult temperament, hostile maternal child-rearing attitudes and insulin resistance syndrome precursors among children: a 3-year follow-up study.

BACKGROUND: We prospectively examined the relationship between latent constructs of perceived difficult temperament and hostile maternal child-rearing attitudes on the one hand, and the cluster of multiple cardiovascular risk factors comprising the insulin resistance syndrome (IRS) on the other. METHODS: A 3-year follow-up study of 451 randomly selected healthy children was used. The temperament of the children and maternal child-rearing attitudes were self-rated by the mothers. The physiological parameters measured were serum insulin, high-density lipoprotein cholesterol (HDL-C), triglycerides, systolic blood pressure, body-mass index and subscapular skinfold thickness. We analyzed the data using structural equation models that involved specific paths allowing separation, and tests of both unique and common (latent) aspects of measured variables. RESULTS: Among boys we found a cross-lagged effect between the latent constructs of perceived difficult temperament and IRS, as well as 1 specific effect from hostile maternal child-rearing attitudes to HDL-C. Among girls there were 6 specific effects from specific measures of perceived temperamental difficultness or hostile maternal child-rearing attitudes that influenced the IRS or its components. CONCLUSIONS: The findings suggest that temperament and maternal child-rearing attitudes may contribute to the early development of the IRS in a gender-specific way among children, thereby potentially increasing the risk of coronary heart disease later in life.

Adolescent↗

PubMed2004

Hostility-aggressiveness, sensation seeking, and sex hormones in men: re-exploring their relationship.

To evaluate the relationship between sex hormones and aggressiveness, hostility and sensation seeking we studied 30 healthy males. Using a standardised technique of radioimmunoassay, we obtained blood values of luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17beta-estradiol (E(2)), total testosterone (TT), sex hormone-binding globulin (SHBG) and the free androgen index (FAI). Personality was evaluated by the Buss-Durkee Hostility Inventory and the Sensation-Seeking Scale, form V. The results showed a lack of significant correlations between the measures of aggressiveness-hostility and hormones. Nevertheless, Spearman and Pearson correlations between Sensation Seeking and testosterone were positive and significant after controlling for age. Considerably higher correlations were obtained after controlling for LH and SHBG. A group of subjects with high scores in a factor made up of Experience Seeking, Disinhibition and Boredom Susceptibility obtained significantly higher scores on TT and FAI. Subjects with high scores in a factor made up of Assault, Indirect Aggression and Verbal Aggression obtained significantly higher scores in SHBG and TT. These findings support Zuckerman's personality model for the sensation-seeking trait.

Adult↗

PubMed1986

Verbal measures of anxiety and hostility under monological and dialogical conditions. A study on a mixed patient sample.

Anxiety and hostility scores (Gottschalk-Gleser method of verbal content analysis) were studied in a mixed patient sample comprising psychosomatic, functional, and neurotic patients under two speech-eliciting conditions: monological and dialogical. Hostility scores did not differ between conditions. Mutilation, diffuse and total anxiety scores were significantly higher in interview than in monologue. In this condition, separation anxiety was expressed more often. Some intercorrelations between variables were found in both conditions, mostly involving hostility, while others hold either for monological or interview data. Factor analysis disclosed different factor structures for the two conditions. An interaction between speech-eliciting condition and diagnostic subgroup is suggested. The implications of these findings for descriptive psychiatric research are discussed.

Adolescent↗

PubMed1975

Hostility, somatic symptoms and recovery with antidepressants.

Patients were treated with protriptyline or nortriptyline (double-blind). They were assessed on the Zung Depression Scale and on the Hostility and Direction of Hostility Questionnaire (HDHQ). A good response was heralded by low ratings on criticism of self and others,and on projected (paranoid) hostility. The outcome was better with initial low scores on depressive symptoms, particularly unworthiness, restlessness and constipation. As to reported side effects, initial loss of interest augured badly for drowsiness, lack of clear mind for blurred vision, loss of libido for constipation and ideas of suicide for dry mouth.

Depression↗

PubMed1975

The differential effects of chlordiazepoxide and oxazepam on hostility in a small group setting.

The authors compared the effects of chlordiazepoxide, oxazepam, and placebo on hostility, as an inner motivational or arousal state, in moderately and highly anxious male research volunteers. The data again supported the hypothesis that clordiazepoxide-induced increases in motivational hostility are more frequent and intense than those associated with placebo and oxazepum. The data also suggest that oxazepam may be a more specific "hostility tranquilizer" than other benzodiazepines.

Chlordiazepoxide↗