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A new species of hairworm, Parachordodes tegonotus n. sp. (Gordioidea: Nematomorpha) is described from three species of ground beetles (Carabidae: Coleoptera) from the state of Oregon. This is the first record of Parachordodes Camerano parasitising carabid beetles in North America. Diagnostic characters for the new species include size, colour, the nature and arrangement of the areoles, and the character, shape and extant of ornamentation on the ventral surface of the male tail. Encysted hairworm larvae found in the internal tissues of mayfly and caddisfly larvae at the type-locality were presumed to be those of P. tegonotus, indicating an indirect life-cycle involving paratenic hosts. A worldwide host list shows that some 70 species of ground beetles have been documented as developmental hosts to hairworms belonging to at least five genera, namely Gordius, Parachordodes, Dacochordodes, Gordionus and Paragordionus.
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Both species are easily distinguished by the shape and the thickness of the buccal ring. In D. noerneri, the buccal ring is 12-14 microns high, kidney like shape in optical section and thick in en face view. In D. viviparus, the buccal ring is 22-25 microns high, triangular shape in optical section and thin in en face view. The taxon Dictyocaulus eckerti Skrjabin, 1931, described from Rangifer larandus in Western Siberia, has been misused to call the Dictyocaulids of european Cervidae. If those are identical to the species of the reindeer, D. eckerti must be synonymysed with D. noerneri, if the two species are different, in any case the Dictyocaulids of european Cervidae must be called D. noerneri.
A stage-dependent increase in the level of putrescine, spermidine, and spermine during intraerythrocytic growth of Plasmodium knowlesi in rhesus monkey erythrocytes was observed. Further, intraerythrocytic P. knowlesi-induced putrescine influx was found in trophozoite stage-infected erythrocytes and process was time- and temperature-dependent and showed saturable kinetics. Characteristics of induced putrescine influx appears in infected erythrocytes to be close to the normal erythrocytes in terms of affinity of putrescine to the putrescine transporter (Km 34.6 +/- 3.8 microM as normal erythrocytes and Km 37.2 +/- 5.2 microM in infected erythrocytes). However, the difference involves the significant increase in the putrescine influx rate after infection (Vmax = 4.21 nmol/min/10(10) normal erythrocytes, compared with 11.6 nmol/min/10(10) infected erythrocytes). Energy dependence, involvement of -SH group, and noninterference by amino acid, spermidine, and spermine in the putrescine influx process clearly demonstrate the presence of a distinct transporter for putrescine in infected erythrocytes. A putrescine conjugate N1,N4-bis(7-chloroquinoline-4-yl)butane-1, 4-diamine (BCBD) was synthesized, which inhibits the putrescine influx in the P. knowlesi infected erythrocytes (Ki of 43.2 microM) as well as in vitro growth of P. knowlesi (IC50 value, 7.64 +/- 0.97 ng/ml BCBD, 10.8 +/- 0.45 ng/ml chloroquine). Addition of exogenous polyamines failed to reverse the inhibitory effect of BCBD in vitro. Administration of BCBD (24 mg/kg body weight, intraperitoneal, twice a day for 4 days) cured the Swiss mice infected with multidrug-resistant infection of Plasmodium yoelii. Therefore, inhibition of putrescine transport in malaria-infected erythrocytes offers a lead in the search of a new class of chemotherapeutic molecules against malaria.
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