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PubMed1982

The influence of dust originated in different coal mines on pneumoconiotic changes in white rats.

In experiments on white rats, three different types of dust of equal dispersion, coming from coal mines, were examined. The dusts exhibited different content of free silica and certain metals, such as: nickel, chromium and vanadium. The animals intratracheally administered with 50 mg of the mentioned dusts had hydroxyproline determined. After six months of experiment, histopathological examination of lungs was carried out. It was found that different SiO2 content (5 and 11%) with the same content of trace metals and different content of trace metals with the same SiO2 content (5%) does not affect hydroxyproline content in lungs. A significant increase in hydroxyproline level in rats' lungs was found in a group that obtained dust of the highest SiO2 content (11%) with more trace metals. Findings of histopathological examinations confirmed the data obtained from hydroxyproline levels measurements. It seems that compounds of certain metals, such as: nickel, chromium, vanadium, at a specific SiO2 level in the dust may increase its fibrogenic properties in lungs.

Animals↗
PubMed1983

[Fibrogenic effect of anthracite dust compared with the effects of hard and bituminous coal dust on the lungs of albino rats].

In experiments on white rats the fibrogenic effects of the dust of anthracite and other types of coal, from the U.S.A. and Poland, were tested. What was found basing on hydroxyproline measurements in lungs was that the extent of fibrogenic effects of anthracite equals fibrogenic effects of bituminous coal dust containing 30% alpha-quartz. Non-anthracite coal dusts containing SiO2 crystalline phases (alpha-quartz) as an admixture--exhibit fibrogenic effects on white rats' lungs--proportional to free silica content. It is probable that fibrogenic effects of anthracite on the pulmonary tissue result from its structure and active free radicals.

Animals↗