Bupropion hydrochloride ((+/-) alpha-t-butylamino-3-chloropropiophenone HCl): a novel antidepressant agent.
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In this paper, the author reviews the dosing strategy for each major class of antidepressant drugs. The long-accepted strategy of moving from low to high dosages may need to be revised when the newer serotonergic agents are used to treat depressed patients. Evidence indicates that these drugs may be both better tolerated and more effective at lower dosages. Several studies in support of this hypothesis are reviewed. Possible dosing strategies of serotonergic agents, such as fluoxetine, in the treatment of obsessive compulsive disorder, obesity, and other nondepressive disorders, are also discussed.
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Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine incorporating the imipramine basic side chain were synthesized and screened for antidepressant activity in mice. With few exceptions, the compounds unsubstituted at C-2 antagonized reserpine-induced ptosis and hypothermia showing negligible anticholinergic and antihistaminic properties. The compound 1-[2-(N-methyl-N-benzylamino)ethyl]-6,7-dihydroindolo[1,7-ab][1]benzazepine had the highest toxicity-activity ratio.