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Serial passage through the brains of newborn mice markedly attenuates the New Jersey strain of EHD virus. Deer inoculated with this attenuated virus show no clinical evidence of illness, but do develop virus-neutralizing antibodies in their sera. They also become solidly immune to infection with the regularly fatal unattenuated virus.
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Calcification of the basal ganglia developed following intracranial hemorrhage in a neonate recovering from severe perinatal asphyxia. Cranial computed tomography is useful in demonstrating the anatomic distribution of dystrophic calcification in regions previously involved by hemorrhage. The demonstration of hemorrhage or hemorrhagic infarction with CT may help to verify the association of basal ganglia calcification with birth anoxia.
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The differential diagosis of masses in the suprarenal area in neonates is discussed in relation to clinical, laboratory and radiologic findings. Neonatal adrenal hemorrhage can be accurately diagnosed clinically. In the neonate neuroblastoma in situ is self-limiting and exploration to exclude it is unnecessary. Operative intervention should be reserved for controlling massive adrenal hemorrhage or if an abscess forms.
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